Inhibitory activity of stilbenes against filamentous fungi

  • Luce Mattio Department of Food, Environmental and Nutritional Sciences, University of Milan, Italy.
  • Giorgia Catinella Department of Food, Environmental and Nutritional Sciences, University of Milan, Italy.
  • Marcello Iriti Department of Agricultural and Environmental Sciences, University of Milan, Italy.
  • Lisa Vallone Department of Health, Animal Science and Food Safety “Carlo Cantoni”, University of Milan (VESPA), Italy.

Abstract

Stilbenoids (resveratrol and its derivatives) are secondary metabolites produced by plants as defence mechanism to microbial infection. These compounds are known for their anti-inflammatory action and health benefits in preventing a wide range of disorders (e.g. cancer and cardiovascular diseases). However, their antimicrobial properties are less investigated. A series of 8 stilbenoid compounds were synthesized and their antifungal activity against 19 wild strains of filamentous fungi and yeasts (isolated from the environment and food) was tested in vitro. Using an agar diffusion assay, compounds were tested at the concentration of 100 μg/ml on filamentous fungi and yeasts at 104 CFU/ml. The results showed that tested derivatives possess moderate antifungal activity: in particular, monomeric stilbenoids 3’-hydroxy-pterostilbene and piceatannol, and dimeric stilbenoids (±)-trans-δ-viniferin and pallidol were active against mycotoxigenic fungi.

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Published
2021-03-25
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Original Articles
Keywords:
stilbenes, resveratrol, antibacterial activity, food-borne fungi
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How to Cite
1.
Mattio L, Catinella G, Iriti M, Vallone L. Inhibitory activity of stilbenes against filamentous fungi. Ital J Food Safety [Internet]. 2021Mar.25 [cited 2021Apr.22];10(1). Available from: https://pagepressjournals.org/index.php/ijfs/article/view/8461