https://doi.org/10.4081/aiua.2021.1.31

Is there a PSA cut-off value indicating incidental prostate cancer in patients undergoing surgery for benign prostatic hyperplasia?

Vol. 93 No. 1 (2021)
Submitted: October 19, 2020
Accepted: December 1, 2020
Published: March 18, 2021
incidental, prostate cancer, open prostatectomy
Abstract Views: 1234
PDF: 626
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Authors

Senol Tonyali
senoltonyali@hotmail.com
Department of Urology, Istanbul University Istanbul School of Medicine, Istanbul, Turkey.
Cavit Ceylan
Department of Urology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
Erdogan Aglamis
Department of Urology, University of Health Sciences, Elazig City Hospital, Elazig, Turkey.
Serkan Dogan
Department of Urology, Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul, Turkey.
Sedat Tastemur
Department of Urology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.
Mustafa Karaaslan
Department of Urology, University of Health Sciences, Ankara City Hospital, Ankara, Turkey.

Aim: To investigate incidental prostate cancer (IPCa) rate and to determine prostate specific antigen (PSA) cut-off value indicating PCa in patients who underwent surgery by being diagnosed with benign prostatic hyperplasia (BPH) clinically or by standard prostate biopsy.
Methods: Data of 317 patients, who underwent transurethral resection of the prostate (TURP) or open prostatectomy (OP) with pre-diagnosis of BPH, were evaluated retrospectively. The examined parameters included patients’ demographics, preoperative serum PSA values, digital rectal examination (DRE) findings, surgical method, histopathological findings and Gleason Scores.
Results: A total of 317 patients were included the study. The median age of patients was 69 years (min: 51-max: 79) and the median PSA value was 3.24 ng/dl (min: 0.17-max: 34.9). In 21 patients (6.6%); DRE findings were in favor of malignancy, but prostate biopsy resulted as BPH. While 281 (88.6%) of the patients underwent TURP, 36 (11.4%) underwent open prostatectomy. PCa was detected in 21 (6.6%) patients. PSA was statistically higher in patients who underwent OP compared to patient who underwent TUR-P, 5.9 (min: 1.2 - max: 27.6, IR: 8.7) vs. 2.8 (min: 0.1-max: 34.9, IR: 4.2) ng/dl, p < .001. The rate of IPCa among four PSA group was similar (p = 0.46). There was no difference between the rate of IPCa in patients younger and older than 70 years, (p = 0.11). Please change whole sentence as 'The median PSA level was slightly higher in patients diagnosed with BPH compared to patients diagnosed with IPCa, 3.2 (min: 0.1-max: 34.9) vs. 2.7 (min: 0.3-max: 26.5) ng/dL, p = 0.9.
Conclusions: IPCa still remains an important clinical problem. We were not able to find any correlation of PSA and age with incidental PCa.

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How to Cite

Tonyali, S., Ceylan, C., Aglamis, E., Dogan, S., Tastemur, S., & Karaaslan, M. (2021). Is there a PSA cut-off value indicating incidental prostate cancer in patients undergoing surgery for benign prostatic hyperplasia?. Archivio Italiano Di Urologia E Andrologia, 93(1), 31–34. https://doi.org/10.4081/aiua.2021.1.31

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