Effects of antioxidant treatment on seminal parameters in patients undergoing in vitro fertilization

  • Laura Gambera | lauragambera@agimedica.it A.G.I. Medica Center for Reproductive Medicine, Siena, Italy.
  • Anita Stendardi A.G.I. Medica Center for Reproductive Medicine, Siena, Italy.
  • Camilla Ghelardi A.G.I. Medica Center for Reproductive Medicine, Siena; Department of Molecular and Developmental Medicine, University of Siena, Italy.
  • Benedetta Fineschi A.G.I. Medica Center for Reproductive Medicine, Siena; Department of Molecular and Developmental Medicine, University of Siena, Italy.
  • Rosamaria Aini A.G.I. Medica Center for Reproductive Medicine, Siena, Italy.

Abstract

Objective: The aim of this non controlled trial was to assess whether a therapy with an antioxidant supplement may improve spermatozoa quality in terms of number, motility, morphology and a higher number of successful conceptions in patients with oligoasthenoteratozoospermia undergoing cycles of medically assisted reproduction by intracytoplasmic sperm injection (ICSI).
Materials and methods: 32 patients registered at A.G.I. Medica (Siena) medically assisted reproduction centre affected by fertility problems associated with oligoasthenoteratozoospermia were included in the study. Semen analysis were evaluated according to World Health Organization 2010, before and after treatment. Moreover, we used colorimetric tests to assess oxidative stress. After evaluating oocyte fertilisation rate and the quality of embryos obtained, data were statistically analysed.
Result: Microscopy examination after the therapy, showed a general improvement in sperm parameters (number of sperms, progressive motility, viability and normal morphology) in both baseline and capacitated; also the levels of oxidative stress was notably lower after the treatment. Morever we evaluated the outcome of the IVF treatment, the percentage of fertilization and the number of embryos obtained, all the parameters was significantly higher in the N1 group.
Conclusions: The outcomes of this trial seem to suggest that the administration of our food supplement improve semen parameters and that the evaluation of oxidative stress levels may become a diagnostic tool to assess male infertility in patients undergoing ART cycle.

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Published
2019-10-02
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Section
Original Papers - Andrology
Keywords:
assisted reproduction technology, embryo quality, male infertility, oxidative stress, reactive oxygen species, semen quality
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How to Cite
Gambera, L., Stendardi, A., Ghelardi, C., Fineschi, B., & Aini, R. (2019). Effects of antioxidant treatment on seminal parameters in patients undergoing in vitro fertilization. Archivio Italiano Di Urologia E Andrologia, 91(3). https://doi.org/10.4081/aiua.2019.3.187