Hibiscus extract, vegetable proteases and Commiphora myrrha are useful to prevent symptomatic UTI episode in patients affected by recurrent uncomplicated urinary tract infections

  • Tommaso Cai | ktommy@libero.it Department of Urology, Santa Chiara Regional Hospital, Trento, Italy.
  • Daniele Tiscione Department of Urology, Santa Chiara Regional Hospital, Trento, Italy.
  • Andrea Cocci Department of Urology, Santa Chiara Regional Hospital, Trento, Italy.
  • Marco Puglisi Department of Urology, Santa Chiara Regional Hospital, Trento, Italy.
  • Gianmartin Cito Department of Urology, University of Florence, Florence, Italy.
  • Gianni Malossini Department of Urology, Santa Chiara Regional Hospital, Trento, Italy.
  • Alessandro Palmieri Department of Urology, University of Naples, Federico II, Naples, Italy.

Abstract

Objective: To evaluate the efficacy of a combination of Hibiscus extract, vegetable proteases and Commiphora myrrha extract in the prophylaxis of symptomatic episode in women affected by recurrent urinary tract infections (rUTIs). Materials and methods: In this phase II clinical trial, all patients with history and diagnosis of rUTI were enrolled. All patients underwent the following treatment schedule: 1 tablet in the morning and 1 tablet in the evening for 7 days and, then, 1 tablet in the evening for 10 days (1 cycle every each month, for 6 months) of a combination of Hibiscus extract, vegetable proteases and Commiphora myrrha extract. At the baseline, all patients underwent urologic visit with quality of life (QoL) questionnaires and mid-stream urine culture. After 3 and 6 months, all patients underwent urologic visit, urine culture and QoL questionnaires evaluation. Results: Fifty-five women were enrolled (mean age 49.3; range: 28-61). At the enrollment time, the most common pathogen was Escherichia coli (63.7%). The median number of UTI per 6 months was 5 (IQR: 4-9). At the end of the second follow-up evaluation, 25 women did not reported any symptomatic episode of UTI (49%), 18 reported less than 2 episodes (35.3%), while 8 reported more than 2 episodes (15.7%). However, at the first and second follow-up evaluation the clinical statistically significant improvement (QoL) was reported by 38/51 (74.5%) (p < 0.001 from baseline) and 43/51 (84.3%) (p < 0.001 from baseline) women, respectively. The median number of UTI decreased to 2 (IQR: 0-3). At the end of the follow-up period, 30/51 had sterile urine (58.8%), while 21/51 (41.2%) reported a transition from symptomatic UTI to asymptomatic bacteriuria. Conclusions: In conclusion, this treatment, in motivated patients, is able to prevent symptomatic UTI symptomatic episode and improve patient’s QoL.

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Published
2018-09-30
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Section
Original Papers - Stones and Infections
Keywords:
Urinary tract infection, Ellirose, Protelix, Serrazimes, Myrliq, plant extracts, antibiotic stewardship, treatment.
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How to Cite
Cai, T., Tiscione, D., Cocci, A., Puglisi, M., Cito, G., Malossini, G., & Palmieri, A. (2018). Hibiscus extract, vegetable proteases and Commiphora myrrha are useful to prevent symptomatic UTI episode in patients affected by recurrent uncomplicated urinary tract infections. Archivio Italiano Di Urologia E Andrologia, 90(3), 203-207. https://doi.org/10.4081/aiua.2018.3.203

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