Improvement of seminal quality and sexual function of men with oligoasthenoteratozoospermia syndrome following supplementation with L-arginine and Pycnogenol®

  • Yoshitomo Kobori | ykobori@dokkyomed.ac.jp Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Keisuke Suzuki Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Toshiyuki Iwahata Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Takeshi Shin Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Yuko Sadaoka Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Ryo Sato Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Kojiro Nishio Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Hiroshi Yagi Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Gaku Arai Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Shigehiro Soh Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Hiroshi Okada Department of Urology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan.
  • Jeffry Michael Strong Horphag Research, Cointrin/Geneva, Switzerland.
  • Peter Rohdewald Institute of Pharmaceutical Chemistry, University of Munster, Munster, Germany.

Abstract

We evaluated the effectiveness of antioxidant co-supplementation therapy using Larginine and Pycnogenol® in Japanese men with oligoasthenozoospermia and mild erectile dysfunction (ED). A total of forty-seven adult males with oligoasthenoteratozoospermia syndrome (OAT) were eligible for enrollment. The effectiveness of supplementation with a combination of L-arginine 690 mg and French maritime pine bark extract (Pycnogenol®) 60mg for OAT and ED was investigated. The sperm concentration was enhanced significantly after treatment 2 and 4 months (11.79 ± 9.86 to 21.22 ± 28.17 and 20.15 ± 23.99 × 106/ml). Significant improvements in the International Index of Erectile Function (IIEF) were observed in the total score of IIEF (57.69 ± 11.04 to 59.43 ± 12.57) and domain of Orgasmic Function (9.01 ± 1.92 to 9.34 ± 1.66) after 4 months of treatment. L-arginine acts to increase the production of nitric oxide and Pycnogenol® activates the endothelial nitric oxide synthase and it is a potent antioxidant and inhibitor of inducible nitric oxide synthase. This study suggests that the combination of Pycnogenol® and L-arginine (Edicare®) is helpful for infertile men to ameliorate simultaneously quality of sperms as well as erectile functions.

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Published
2015-09-30
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Section
Original Papers - Andrology
Keywords:
Male infertility, Spermatogenesis, erectile dysfunction, L-arginine, Pycnogenol
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How to Cite
Kobori, Y., Suzuki, K., Iwahata, T., Shin, T., Sadaoka, Y., Sato, R., Nishio, K., Yagi, H., Arai, G., Soh, S., Okada, H., Strong, J., & Rohdewald, P. (2015). Improvement of seminal quality and sexual function of men with oligoasthenoteratozoospermia syndrome following supplementation with L-arginine and Pycnogenol®. Archivio Italiano Di Urologia E Andrologia, 87(3), 190-193. https://doi.org/10.4081/aiua.2015.3.190