What is the correct staging and treatment strategy for locally advanced prostate cancer extending to the bladder?

  • Özgür Haki Yüksel | ozgurhaki@gmail.com Fatih Sultan Mehmet Research & Training Hospital, Dept. of Urology, Istanbul, Turkey.
  • Ayhan Verit Fatih Sultan Mehmet Research & Training Hospital, Dept. of Urology, Istanbul, Turkey.
  • Ahmet Ürkmez Fatih Sultan Mehmet Research & Training Hospital, Dept. of Urology, Istanbul, Turkey.

Abstract

In locally advanced prostate cancer with bladder invasion, frequently encountered problems such as bleeding, urinary retention, hydronephrosis, and pain create distress for the patients. Therefore patients’ quality of life is disrupted and duration of hospitalization is prolonged. Relevant literature about accurate staging and treatment of locally advanced prostate cancer with bladder invasion was investigated. Locally advanced prostate cancer can present as a large-volume aggressive tumor extending beyond boundaries of prostate gland, and involving neighboring structures which can be involved as recurrence(s) following initial local therapy. Survival times of these patients can range between 5 and 8 years. Their common characteristics are adverse and severe local symptoms unfavorably affecting quality of life Control of local symptoms and their effective palliation are independent clinical targets influencing survival outcomes of these patients. The treatment outcomes of locally advanced prostate cancer into the bladder are currently debatable. Although in the current TNM classification, it is defined in T4a, we think that this may be categorized as a subgroup of T3 and thus encourage surgeons for the indication of radical surgeries (radical prostatectomy, radical cystoprostatectomy) in selected patient populations after discussing issues concerning consequences of the treatment alternatives, and expectations with the patients. Cystoprostatectomy followed by immediate androgen deprivation therapy may be a feasible option for selected patients with previously untreated prostate cancer involving the bladder neck because of excellent local control and long term survival.

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Published
2015-07-07
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Issue
Section
Original Papers - Prostate
Keywords:
Bladder neck invasion, Cystoprostatectomy, Locally advanced prostate cancer, Radical prostatectomy, Staging
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  • PDF: 763
How to Cite
Yüksel, Özgür H., Verit, A., & Ürkmez, A. (2015). What is the correct staging and treatment strategy for locally advanced prostate cancer extending to the bladder?. Archivio Italiano Di Urologia E Andrologia, 87(2), 130-135. https://doi.org/10.4081/aiua.2015.2.130

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