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Pathological issues in biopsy specimens of men with prostate cancer eligible for active surveillance

Roberta Mazzucchelli, Andrea Benedetto Galosi, Antonio Lopez-Beltran, Marina Scarpelli, Liang Cheng, Rodolfo Montironi
  • Roberta Mazzucchelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
  • Andrea Benedetto Galosi
    Division of Urology, “Augusto Murri” General Hospital, ASUR Marche, Fermo, Italy
  • Antonio Lopez-Beltran
    Department of Surgery, Cordoba University Medical School, Cordoba, Spain
  • Marina Scarpelli
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
  • Liang Cheng
    Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, United States
  • Rodolfo Montironi
    Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy | r.montironi@univpm.it

Abstract

Active surveillance (AS) is an important management option for men with lowrisk, clinically localized prostate cancer. The clinical parameters for patient selection and definition of progression for AS protocols are evolving as data from several large cohorts become mature. Vital to this process is the critical role pathologic parameters play in identifying appropriate candidates for AS. These findings need to be reproducible and accurately reported by pathologists. Repeated biopsy after initial diagnosis of prostate cancer is recommended before inclusion in active surveillance for early detection of significant cancer.

Keywords

Prostate cancer; Prostate biopsy; Active surveillance; Tumour extent; Immunohistochemistry

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Submitted: 2015-01-23 14:56:27
Published: 2014-12-30 00:00:00
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Copyright (c) 2014 Roberta Mazzucchelli, Andrea Benedetto Galosi, Antonio Lopez-Beltran, Marina Scarpelli, Liang Cheng, Rodolfo Montironi

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