https://doi.org/10.4081/aiua.2021.3.336

Effect of bladder dysfunction on development of depression and anxiety in Parkinson’s disease

Vol. 93 No. 3 (2021)
Submitted: May 13, 2021
Accepted: June 25, 2021
Published: October 1, 2021
Bladder Dysfunction, Anxiety, Depression, Parkinson’s disease
Abstract Views: 1134
PDF: 604
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Erdal Benli
Department of Urology, Ordu University, Faculty of Medicine, Ordu, Turkey.
Fahriye Feriha Ozer
Department of Neurology, Koç University Faculty of Medicine, Istanbul, Turkey.
Nesrin Helvacı Yılmaz
Department of Neurology, Istanbul Medipol University, Faculty of Medicine, Istanbul, Turkey.
Ozge Arici Duz
Department of Neurology, Istanbul Medipol University, Faculty of Medicine, Istanbul, Turkey.
Ahmet Yuce
ahmetyuce7@gmail.com
Department of Urology, Darende Hulusi Efendi State Hospital, Malatya, Turkey.
Abdullah Cirakoglu
Department of Urology, Ordu University, Faculty of Medicine, Ordu, Turkey.
Tuba Saziye Ozcan
Department of Neurology, Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul, Turkey.

Objectives: Parkinson's disease (PD) often presents with movement disorder. However, besides motor complaints, there are many complaints such as anxiety, depression, urinary complaints and constipation. The aim of this study was to investigate whether neurogenic lower urinary dysfunction (NLUD), which is frequently seen in PD, has an effect on the development of anxiety and depression in these patients.
Materials and methods: The study included 32 males (66.6%) and 16 females (33.3%); in total 48 subjects were registered. For the diagnosis and severity of PD, the UK Parkinson's Disease Society Brain Bank Criteria, Unified Parkinson's Disease Rating Scale (UPDRS) and the Hoehn-Yahr scale were used. Urological evaluation was performed using history, physical examination, laboratory tests and standard forms such as IPSS and OAB-V8.
Results: There was no difference between the genders in terms of duration, severity and NLUD (p > 0.05). The incidence of anxiety and depression in PD patients was 62.8% and 72.1%, respectively. The prevalence of NLUD was 67.4% and depression and anxiety was found to increase (1.06 and 1.28 times, respectively) in relation to NLUD. In particular, there was a relationship between storage lower urinary tract symptoms and anxiety and depression development (p < 0.05).
Conclusions: As expected, it was found that the incidence of NLUD, anxiety and depression was increased in PD. In addition, NLUD was found to be a risk factor for the development of anxiety and depression. Therefore, it is concluded that NLUD, which can potentially cause important complications, as well as motor complaints, should be closely monitored and treated in PD patients.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Chen JJ. Parkinson's disease: health-related quality of life, economic cost, and implications of early treatment. Am J Manag Care. 2010; 16:87-93.
Campos-Sousa RN, Quagliato EM, Almeida KJ, et al. Urinary dysfunction with detrusor hyperactivity in women with Parkinson's disease cannot be blamed as a factor of worsening motor performance. Arq Neuropsiquiatr. 2013; 71:591-595.
Schrag A, Dodel R, Spottke A, et al. Rate of clinical progression in Parkinson's disease. A prospective study. Mov Disord. 2007; 22:938-945. DOI: https://doi.org/10.1002/mds.21429
Wong SY, Hong A, Leung J, et al. Lower urinary tract symptoms and depressive symptoms in elderly men. J Affect Disord. 2006;96:83-88. DOI: https://doi.org/10.1016/j.jad.2006.05.013
Fahn S, Elton RL. Unified Parkinson’s Disease Rating Scale. In: Fahn S, Marsden CD, Goldsteijn M, Calne DB, Editors. Recent Developments ın Parkinson’s Disease. Macmillan Healthcare Information. 1987; 2:153-163.
Hoehn MM, Yahr MD. Parkinsonism: Onset, progression and mortality. Neurology. 1967; 17:427-442. DOI: https://doi.org/10.1212/WNL.17.5.427
Maier W, Buller R, Philipp M, Heuser I. The Hamilton Anxiety Scale: reliability, validity and sensitivity to change in anxiety and depressive disorders. J Affect Disord. 1988; 14:61-68. DOI: https://doi.org/10.1016/0165-0327(88)90072-9
McVary KT, Roehrborn CG, Avins AL, et al. Update on AUA guideline on the management of benign prostatic hyperplasia. J Urol. 2011; 185:1793-1803. DOI: https://doi.org/10.1016/j.juro.2011.01.074
Abrams P, Cardozo L, Fall M, et al. Standardisation Sub-committee of the International Continence Society. The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourology and Urodynamics. 2002; 21:167-178. DOI: https://doi.org/10.1002/nau.10052
Moussa M, Papatsoris AG, Abou Chakra M, et al. Erectile dysfunction in common neurological conditions: A narrative review. Arch Ital Urol Androl. 2020; 92:371-385. DOI: https://doi.org/10.4081/aiua.2020.4.371
Gallagher DA, Lees AJ, Schrag A. What are the most important nonmotor symptoms in patients with Parkinson's disease and are we missing them? Mov Disord. 2010; 25:2493-2500. DOI: https://doi.org/10.1002/mds.23394
Benli E, Özer FF, Kaya Y, et al. Is there a difference between Parkinson disease patients and a control group in terms of urinary symptoms and quality of life? Turk J Med Sci. 2016; 46:1665-1671. DOI: https://doi.org/10.3906/sag-1507-148
Sakakibara R, Tateno F, Nagao T, et al. Bladder function of patients with Parkinson's disease. Int J Urol. 2014; 21:638-646. DOI: https://doi.org/10.1111/iju.12421
Uchiyama T, Sakakibara R, Yamamoto T, et al. Urinary dysfunction in early and untreated Parkinson's disease. J Neurol Neurosurg Psychiatry. 2011; 82:1382-1386. DOI: https://doi.org/10.1136/jnnp.2011.241075
Yoshimura N, Kuno S, Chancellor MB, et al. Dopaminergic mechanisms underlying bladder hyperactivity in rats with a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal pathway. Br J Pharmacol. 2003;139:1425-1432. DOI: https://doi.org/10.1038/sj.bjp.0705388
Campos-Sousa RN, Quagliato EM, Almeida KJ, et al. Urinary dysfunction with detrusor hyperactivity in women with Parkinson's disease cannot be blamed as a factor of worsening motor performance. Arq Neuropsiquiatr. 2013;71:591-595. DOI: https://doi.org/10.1590/0004-282X20130101
Brown JS, Vittinghoff E, Wyman JF, et al. Urinary incontinence: does it increase risk forfalls and fractures? Study of Osteoporotic Fractures Research Group. J Am Geriatr Soc 2000; 48:721-725. DOI: https://doi.org/10.1111/j.1532-5415.2000.tb04744.x
Starkstein SE, Preziosi TJ, Forrester AW, Robinson RG. Specificity of affective and autonomic symptoms of depression in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1990; 53:869-873. DOI: https://doi.org/10.1136/jnnp.53.10.869
Lyons KE, Pahwa R. The impact and management of nonmotor symptoms of Parkinson's disease. Am J Manag Care. 2011; 12:308-314.
Engström G, Henningsohn L, Steineck G, Leppert J. Self-assessed health, sadness and happiness in relation to the total burden of symptoms from the lower urinary tract. BJU Int. 2005; 95:810-815. DOI: https://doi.org/10.1111/j.1464-410X.2005.05406.x
Irwin DE, Milsom I, Kopp Z, et al. Impact of overactive bladder symptoms on employment, social interactions and emotional wellbeing in six European countries. BJU Int. 2006; 97:96-100. DOI: https://doi.org/10.1111/j.1464-410X.2005.05889.x
Brittain KR, Castleden CM. Suicide in patients with stroke. Depression may be caused by symptoms affecting lower urinary tract. BMJ. 1998; 317:1016-1067. DOI: https://doi.org/10.1136/bmj.317.7164.1016b
Melville JL, Delaney K, Newton K, Katon W. Incontinence severity and major depression in incontinent women. Obstet Gynecol. 2005; 106:585-592. DOI: https://doi.org/10.1097/01.AOG.0000173985.39533.37
Soh SE, Morris ME, McGinley JL. Determinants of health-related quality of life in Parkinson's disease: a systematic review. Parkinsonism Relat Disord. 2011; 17:1-9. DOI: https://doi.org/10.1016/j.parkreldis.2010.08.012
Schwarz J, Odin P, Buhmann C, et al. Depression in Parkinson's disease. J Neurol. 2011; 258:336-338. DOI: https://doi.org/10.1007/s00415-011-6048-3

How to Cite

Benli, E., Ozer, F. F., Helvacı Yılmaz, N. ., Arici Duz, O., Yuce, A. ., Cirakoglu, A., & Ozcan, T. S. (2021). Effect of bladder dysfunction on development of depression and anxiety in Parkinson’s disease. Archivio Italiano Di Urologia E Andrologia, 93(3), 336–340. https://doi.org/10.4081/aiua.2021.3.336

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.