https://doi.org/10.4081/aiua.2021.2.143

Endothelin-1 indicates unfavorable prognosis in primary high-grade non-muscle-invasive urothelial bladder cancer

Vol. 93 No. 2 (2021)
Submitted: November 17, 2020
Accepted: January 23, 2021
Published: June 28, 2021
ET-1, High-grade, Non-muscle-invasive bladder cancer, Prognosis
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Authors

Lampros Mitrakas
lamprosmit@gmail.com
https://orcid.org/0000-0002-2563-5833
Department of Urology, Faculty of Medicine-School of Health Sciences-University of Thessaly, University Hospital of Larissa, Greece, Greece.
Stavros Gravas
Department of Urology, Faculty of Medicine-School of Health Sciences-University of Thessaly, University Hospital of Larissa, Greece, Greece.
Foteini Karasavvidou
Department of Pathology and Cytology, Faculty of Medicine-School of Health Sciences-University of Thessaly, University Hospital of Larissa, Greece.
Ioannis Zachos
Department of Urology, Faculty of Medicine-School of Health Sciences-University of Thessaly, University Hospital of Larissa, Greece, Greece.
Anastasios Karatzas
Department of Urology, Faculty of Medicine-School of Health Sciences-University of Thessaly, University Hospital of Larissa, Greece, Greece.
Athanasios Oeconomou
Department of Urology, Faculty of Medicine-School of Health Sciences-University of Thessaly, University Hospital of Larissa, Greece, Greece.
Georgios Koukoulis
Department of Pathology and Cytology, Faculty of Medicine-School of Health Sciences-University of Thessaly, University Hospital of Larissa, Greece.
Vasilios Tzortzis
Department of Urology, Faculty of Medicine-School of Health Sciences-University of Thessaly, University Hospital of Larissa, Greece, Greece.
Christos Papandreou
Department of Oncology, School of Medicine, Aristotle University of Thessaloniki, “N.Papageorgiou” Hospital of Thessaloniki, Ring Road of Thessaloniki, Greece.

Objective: To conduct a prospective study of the potential prognostic role of endothelin-1 (ET-1) in a cohort of primary high-grade non-muscle-invasive urothelial bladder cancer patients, who were treated with adjuvant intravesical Bacillus Calmette-Guérin (BCG).
Material and methods: Patients with primary high-grade nonmuscle- invasive urothelial bladder cancer, who received postoperatively induction and maintenance BCG therapy, were prospectively included. Recurrence and progression were histologically proven. Immunohistochemical staining for ET-1 was assessed. Epidemiological, pathological and clinical parameters as well as the expression of ET-1 in tumor specimens were statistically analyzed for recurrence, progression, recurrence-free survival (RFS) and progression-free survival (PFS).
Results: ET-1 associates significantly with recurrence (p = 0.000), progression (p = 0.000), RFS (p = 0.000) and PFS (p = 0.000). The patient’s age is also significant for recurrence (p = 0.003, OR = 1.273 95% CI: 1.086-1.492) and RFS (p = 0.013).
Conclusions: ET-1 seems to deteriorate prognosis in patients suffering from primary high-grade non-muscle-invasive urothelial bladder cancer, who are treated with adjuvant BCG instillations. Furthermore, the patient’s age associates with an increased likelihood for recurrence.

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How to Cite

Mitrakas, L. ., Gravas, S. ., Karasavvidou, F. ., Zachos, I. ., Karatzas, A. ., Oeconomou, A. ., Koukoulis, G. ., Tzortzis, V. ., & Papandreou, C. . (2021). Endothelin-1 indicates unfavorable prognosis in primary high-grade non-muscle-invasive urothelial bladder cancer. Archivio Italiano Di Urologia E Andrologia, 93(2), 143–147. https://doi.org/10.4081/aiua.2021.2.143

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