Intraoperative hydrodissection and Doppler ultrasound during magnified varicocelectomy: A comparative study

Submitted: November 13, 2022
Accepted: December 24, 2022
Published: February 22, 2023
Abstract Views: 849
PDF: 367
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Methods: We performed a non-randomized comparative trial that recruited infertile men with varicocele who were scheduled to undergo MSV. Eligible patients were allocated by the investigators in a 1:1 ratio to receive intraoperative Doppler (group I) or intraoperative Doppler plus hydrodissection (group II).

Results: Sixty men were included in each group. The two study groups showed a comparable number of ligated veins on the right (4.22 ±1.57 versus 4.42 ± 1.65; p = 0.49) and left side (6.77 ± 2.14 versus 6.98 ± 2.29; p = 0.59). On the contrary, group II showed a significantly higher number of preserved arteries on the right (2.42 ± 0.56 versus 1.47 ±0.5 in group I) and left side (2.6 ± 0.53 versus 1.63 ± 0.55 in group I), with p-value < 0.001. The sperm motility was significantly higher in group II than in group I (21.25 ± 13.73 versus 13.85 ± 12.25, respectively; p = 0.002). In both groups, the sperm motility increased significantly at the end of follow-up compared to the preoperative period. The postoperative sperm mortality remained significantly higher in group II than in group I (p = 0.008).

Conclusions: Intraoperative Doppler plus hydrodissection (D+IH-MSV) has advantages in preserving more arteries and enhancing the motility of sperms. Based on these findings, we strongly recommend D+IH-MSV when treating infertile men with varicocele.

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Cocuzza M, Cocuzza MA, Bragais FM, Agarwal A. The role of varicocele repair in the new era of assisted reproductive technology. Clinics (Sao Paulo). 2008; 63:395-404. DOI: https://doi.org/10.1590/S1807-59322008000300018
Dubin L, Amelar RD. Varicocelectomy: 986 cases in a twelve-year study. Urology. 1977; 10:446-9. DOI: https://doi.org/10.1016/0090-4295(77)90132-7
Shridharani A, Lockwood G, Sandlow J. Varicocelectomy in the treatment of testicular pain: a review. Curr Opin Urol. 2012; 22:499-506. DOI: https://doi.org/10.1097/MOU.0b013e328358f69f
Lundy SD, Sabanegh ES Jr. Varicocele management for infertility and pain: A systematic review. Arab J Urol. 2017; 16:157-170. DOI: https://doi.org/10.1016/j.aju.2017.11.003
Schlegel PN, Goldstein M. Anatomical approach to varicocelecto-my. Semin Urol. 1992; 10:242-7.
Chan PT, Wright EJ, Goldstein M. Incidence and postoperative outcomes of accidental ligation of the testicular artery during micro-surgical varicocelectomy. J Urol. 2005; 173:482-4. DOI: https://doi.org/10.1097/01.ju.0000148942.61914.2e
Guo L, Sun W, Shao G, et al. Outcomes of Microscopic Subinguinal Varicocelectomy With and Without the Assistance of Doppler Ultrasound: A Randomized Clinical Trial. Urology. 2015; 86:922-8. DOI: https://doi.org/10.1016/j.urology.2015.08.002
Tatem AJ, Brannigan RE. The role of microsurgical varicocelecto-my in treating male infertility. Transl Androl Urol. 2017; 6:722-9. DOI: https://doi.org/10.21037/tau.2017.07.16
Cocuzza M, Pagani R, Coelho R, et al. The systematic use of intra-operative vascular Doppler ultrasound during microsurgical subin-guinal varicocelectomy improves precise identification and preserva-tion of testicular blood supply. Fertil Steril. 2010; 93:2396-9. DOI: https://doi.org/10.1016/j.fertnstert.2009.01.088
World Medical Association. World Medical Association Declaration of Helsinki. Ethical principles for medical research involv-ing human subjects. Bull World Health Organ. 2001; 79:373-4. DOI: https://doi.org/10.4414/fms.2001.04031
Sarteschi M, Paoli R, Bianchini M, Menchini Fabris GF. Lo stu-dio del varicocele con eco-color-Doppler. G Ital Ultrasonol 1993; 4:43-9.
World Health Organization. WHO laboratory manual for the examination and processing of human semen (Sixth edition) 2021 Available from: http://whqlibdoc.who.int/publications/2010/ 9789241547789_eng.pdf
Marmar JL, Agarwal A, Prabakaran S, et al. Reassessing the value of varicocelectomy as a treatment for male subfertility with a new meta-analysis. Fertil Steril. 2007; 88:639-48. DOI: https://doi.org/10.1016/j.fertnstert.2006.12.008
Agarwal A, Deepinder F, Cocuzza M, et al. Efficacy of varicoc-electomy in improving semen parameters: new meta-analytical approach. Urology. 2007; 70:532-8. DOI: https://doi.org/10.1016/j.urology.2007.04.011
Reyes JG, Farias JG, Henríquez-Olavarrieta S, et al. The hypoxic testicle: physiology and pathophysiology. Oxid Med Cell Longev. 2012; 2012:929285. DOI: https://doi.org/10.1155/2012/929285
Marmar JL, DeBenedictis TJ, Praiss D. The management of varicoceles by microdissection of the spermatic cord at the external inguinal ring. Fertil Steril. 1985; 43:583-8. DOI: https://doi.org/10.1016/S0015-0282(16)48501-8
Goldstein M, Gilbert BR, Dicker AP, et al. Microsurgical inguinal varicocelectomy with delivery of the testis: an artery and lymphatic sparing technique. J Urol. 1992; 148:1808-11. DOI: https://doi.org/10.1016/S0022-5347(17)37035-0
Shindel AW, Yan Y, Naughton CK. Does the number and size of veins ligated at left-sided microsurgical subinguinal varicocelectomy affect semen analysis outcomes? Urology. 2007; 69:1176-80. DOI: https://doi.org/10.1016/j.urology.2007.01.086
Soetandar A, Noegroho BS, Siregar S, et al. Microsurgical varic-ocelectomy effects on sperm DNA fragmentation and sperm param-eters in infertile male patients: A systematic review and meta-analy-sis of more recent evidence. Arch Ital Urol Androl. 2022; 94:360-5. DOI: https://doi.org/10.4081/aiua.2022.3.360
Salama N, Blgozah S. Immediate development of post-varicoc-electomy hydrocele: a case report and review of the literature. J Med Case Rep. 2014; 8:70. DOI: https://doi.org/10.1186/1752-1947-8-70
Paduch DA, Niedzielski J. Repair versus observation in adoles-cent varicocele: a prospective study. J Urol. 1997; 158:1128-32. DOI: https://doi.org/10.1016/S0022-5347(01)64403-3
Atteya A, Amer M, AbdelHady A, Al-Azzizi H, et al. Lymphatic vessel hydrodissection during varicocelectomy. Urology. 2007; 70:165-7. DOI: https://doi.org/10.1016/j.urology.2007.04.012

How to Cite

Shebl, S. E., Ali, S., & El Gammal, A. (2023). Intraoperative hydrodissection and Doppler ultrasound during magnified varicocelectomy: A comparative study. Archivio Italiano Di Urologia E Andrologia, 95(1). https://doi.org/10.4081/aiua.2023.11008