https://doi.org/10.4081/aiua.2022.4.428

AB0 blood groups and oncological and functional outcomes in bladder cancer patients treated with radical cystectomy

Vol. 94 No. 4 (2022)
Submitted: September 21, 2022
Accepted: October 2, 2022
Published: December 27, 2022
ABO, Blood groups, Bladder Cancer, Radical Cystectomy, Outcomes
Abstract Views: 613
PDF: 308
Supplementary Material: 50
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Authors

Alessandro Tafuri
aletaf@hotmail.it
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy; Department of Urology, “Vito Fazzi” Hospital, Lecce, Italy.
Andrea Panunzio
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy; Cancer and Prognostics Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Quebec, Canada.
Antonio Soldano
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Giovanni Mazzucato
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Paola Irene Ornaghi
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Giacomo Di Filippo
Department of General and Hepatobiliary Surgery, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
Alessandra Gozzo
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Nicola De Maria
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Francesco Cianflone
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Aliasger Shakir
USC Institute of Urology, Catherine and Joseph Aresty Department of Urology, Keck School of Medicine, University of Southern California (USC), Los Angeles, United States.
Zhe Tian
Cancer and Prognostics Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Quebec, Canada.
Matteo Brunelli
Department of Pathology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Antonio Benito Porcaro
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Vincenzo Pagliarulo
Department of Urology, “Vito Fazzi” Hospital, Lecce, Italy.
Walter Artibani
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Pierre I. Karakiewicz
Cancer and Prognostics Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Quebec, Canada.
Alessandro Antonelli
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Maria Angela Cerruto
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.

Objectives: We investigated AB0 blood groups prevalence according to preoperative and pathological tumor characteristics, and their association with oncological outcomes, and renal function decline in a contemporary large cohort of bladder cancer (BCa) patients, who underwent radical cystectomy (RC) at a tertiary referral center.
Materials and Methods: We retrospectively evaluated data of patients with histologically confirmed and clinically non metastatic BCa, who underwent RC between 2014 and 2021 at our Institution. Kaplan-Meier (KM) plots and Cox regression (CR) models tested the relationship between AB0 blood groups and local recurrence-, metastasis-, cancer specific mortality-, and overall mortality-free survival. Logistic regression (LR) models tested the association between AB0 blood groups and renal function decline, defined as an estimated Glomerular Filtration Rate (eGFR) < 60 mL/min, at post-operative day 1, discharge and 6- months of follow-up.
Results: Of 301 included patients, 128 (42.5%) had group A, 126 (41.9%) had group 0, 28 (9.3%) had group B, and 19 (6.3%) had group AB. Patients with group 0 developed higher rates of muscle- invasive BCa (p = 0.028) with high-grade features (p = 0.005) at last bladder resection, and less frequently received preoperative immunotherapy with Bacillus of Calmette-Guerin (p = 0.044), than their non-0 counterparts. Additionally, these patients harbored more advanced pathologic tumor stage at RC (p = 0.024). KM plots showed no differences among all tested cancer control outcomes between AB0 blood groups (p > 0.05 in all cases). Patients with group AB presented the lowest median eGFR at each time point. In multivariable LR analyses addressing renal function decline, group AB was independently associated with eGFR< 60 mL/min at discharge (Odds Ratio: 4.28, p = 0.047).
Conclusions: Among AB0 blood groups, patients with group 0 exhibited the most aggressive tumor profile. However, no differences were recorded in recurrence or survival rates. Group AB independently predicted renal function decline at discharge.

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How to Cite

Tafuri, A., Panunzio, A., Soldano, A., Mazzucato, G., Ornaghi, P. I., Di Filippo, G., Gozzo, A., De Maria, N., Cianflone, F., Shakir, A., Tian, Z., Brunelli, M., Porcaro, A. B., Pagliarulo, V., Artibani, W., Karakiewicz, P. I., Antonelli, A., & Cerruto, M. A. (2022). AB0 blood groups and oncological and functional outcomes in bladder cancer patients treated with radical cystectomy. Archivio Italiano Di Urologia E Andrologia, 94(4), 428–433. https://doi.org/10.4081/aiua.2022.4.428
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