Outcomes of nephrectomy for renal cell carcinoma: An ecologic retrospective study in a middle-income country

Submitted: March 25, 2022
Accepted: May 31, 2022
Published: June 28, 2022
Abstract Views: 1605
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Objective: The aim of this study was to describe and compare the outcomes and indirect costs of oncological radical (RN) and partial nephrectomies (PN) in hospitals from the São Paulo public health system, Brazil.
Materials and methods: An ecologic retrospective study was performed from 2008 to 2019, using the TabNet Platform of the Brazilian Unified Health System Department of Informatics. Hospitals were classified according to volume of surgeries (low and high-volume, and also into four quartiles according to volume of surgeries), and with or without medical residency program in urology. The results were compared between groups.
Results: In the period analyzed were performed 2.606 RN in 16 hospitals. Data available for PN ranged only from 2013-2019 and included 1.223 surgeries comprising 15 hospitals. Overall mortality rates were 0.41% for PN and 2.87% for RN. The length of hospital stay was significantly higher in low-volume hospitals for both RN and PN (8.97 vs. 5.62 days, p = 0.001, and 7.75 vs. 4.37 days, p = 0.001, respectively), and also for the RN in hospitals without residency program in Urology (9.37 vs. 6.54 days, p = 0.03). When the volume of surgeries was divided into four quartiles, the length of hospital stay and ICU hospitalization days were significantly higher in the first quartile hospitals for RN (p = 0.016) and PN (p = 0.009), respectively. The mortality rates and indirect costs were not different considering PN and RN in the different types of hospitals.
Conclusions: The length of hospital stay was significantly lower for both PN and RN in high-volume hospitals, and also for RN in hospitals with residency program in Urology.

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Citations

Atkins, MB; Choueiri, TK. Epidemiology, pathology, and pathogenesis of renal cell carcinoma. Waltaham, MA: Wolters Kluwer, 2020.
Campbell SL. Malignant Renal Tumors. In: Wein A, Kavoussi L, Partin A, Peters C. Ed. Campbell-Walsh Urology. 11th. Philadelphia, PA: Elselvier, 2016, chapter 57, p.1314-1364.
Siegel R, Naishadham D, Jemal A. Cancer statistics, 2013. CA Cancer J Clin. 2013; 63:11-30. DOI: https://doi.org/10.3322/caac.21166
Ferlay J, Colombet M, Soerjomataram I, et al. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries and 25 major cancers in 2018. Eur J Cancer. 2018; 103:356-387. DOI: https://doi.org/10.1016/j.ejca.2018.07.005
Jemal A, Bray F, Center MM, et al. Global cancer statistics. CA Cancer J Clin. 2011; 61:69-90. DOI: https://doi.org/10.3322/caac.20107
Parsons JK, Schoenberg MS, Carter HB. Incidental renal tumors: casting doubt on the efficacy of early intervention. Urol. 2001; 57:1013-5. DOI: https://doi.org/10.1016/S0090-4295(01)00991-8
Decastro GJ, McKiernan JM. Epidemiology, clinical staging, and presentation of renal cell carcinoma. Urol Clin North Am. 2008; 35:581-92. DOI: https://doi.org/10.1016/j.ucl.2008.07.005
Brierley JD. TNM Classification of Malignant Tumors. UICC international Union Against Cancer. In: Sobin LH, Gospodarowicz MK, Wittekind C. TNM Classification of Malignant Tumors. 7th. Chichester, West Sussex: Wiley-Blackwell, 2009.
Huang WC, Levey AS, Serio AM, et al. Chronic kidney disease after nephrectomy in patients with renal cortical tumours: a retrospective cohort study. Lancet Oncol. 2006; 7:735-40. DOI: https://doi.org/10.1016/S1470-2045(06)70803-8
Sciorio C, Prontera PP, Scuzzarella S, et al. Predictors of surgical outcomes of retroperitoneal laparoscopic partial nephrectomy. Arch Ital Urol Androl. 2020; 92:165-168. DOI: https://doi.org/10.4081/aiua.2020.3.165
Kim SP, Murad MH, Thompson RH, et al. Comparative effectiveness for survival and renal function of partial and radical nephrectomy for localized renal tumors: a systematic review and meta-analysis. J Urol. 2012; S0022-5347(12)05254-8. DOI: https://doi.org/10.1016/j.juro.2012.10.026
Huang WC, Elkin EB, Levey AS, et al. Partial nephrectomy versus radical nephrectomy in patients with small renal tumors--is there a difference in mortality and cardiovascular outcomes? J Urol. 2009; 181:55-61. DOI: https://doi.org/10.1016/j.juro.2008.09.017
Van Poppel H, Da Pozzo L, Albrecht W, et al. A prospective, randomised EORTC intergroup phase 3 study comparing the oncologic outcome of elective nephron-sparing surgery and radical nephrectomy
for low-stage renal cell carcinoma. Eur Urol. 2011; 59:543-52. DOI: https://doi.org/10.1016/j.eururo.2010.12.013
Adams KF, Leitzmann MF, Albanes D, et al. Body size and renal cell cancer incidence in a large US cohort study. Am J Epidemiol. 2008; 168:268-77. DOI: https://doi.org/10.1093/aje/kwn122
Scosyrev E, Messing EM, Sylvester R, et al. Renal function after nephron-sparing surgery versus radical nephrectomy: results from EORTC randomized trial 30904. Eur Urol. 2014; 65:372-7. DOI: https://doi.org/10.1016/j.eururo.2013.06.044
Kates M, Badalato GM, Pitman M, McKiernan JM. Increased risk of overall and cardiovascular mortality after radical nephrectomy for renal cell carcinoma 2 cm or less. J Urol. 2011; 186:1247-53. DOI: https://doi.org/10.1016/j.juro.2011.05.054
IBGE. Estimativas da População Residente para os Municípios e para as Unidades da Federação Brasileiros com data de Referência de 1o de Julho de 2019. SAÚDE, M. D. Rio de Janeiro, RJ, Brasil: IBGE 2019. Available at https://www.ibge.gov.br/estatisticas/sociais/populacao/9103-estimativas-de-populacao.html?=&t=o-que-e.
Boletim CEInfo Saúde em Dados. Ano XVIII. São Paulo, SP, Brasil: Secretaria Municipal de Saúde 2019. Available at https://www.prefeitura.sp.gov.br/cidade/secretarias/saude/epidemiologia_e_informacao/index.php?p=258529.
Couapel JP, Bensalah K, Bernhard JC, et al. Is there a volumeoutcome relationship for partial nephrectomy? World J Urol. 2014; 32:1323-9. DOI: https://doi.org/10.1007/s00345-013-1213-1
Birkmeyer JD, Siewers AE, Finlayson EV, et al. Hospital volume and surgical mortality in the United States. N Engl J Med. 2002; 346:1128-37. DOI: https://doi.org/10.1056/NEJMsa012337
Gaston KE, Moore DT, Pruthi RS. Hand-assisted laparoscopic nephrectomy: prospective evaluation of the learning curve. J Urol. 2004; 171:63-7. DOI: https://doi.org/10.1097/01.ju.0000099400.50350.9b
Rouach Y, Timsit MO, Delongchamps NB, et al. Néphrectomie partielle laparoscopique: courbe d'apprentissage d'un interne en urologie sur un modèle porcin [Laparoscopic partial nephrectomy: urology resident learning curve on a porcine model]. Prog Urol. 2008; 18:344-50. DOI: https://doi.org/10.1016/j.purol.2008.03.009
Baez-Suarez Y, Amaya-Nieto J, Garcia-Lopez A, Giron-Luque F. Hand-assisted laparoscopic nephrectomy:evaluation of the learning curve. Transplant Proc. 2020; 52:67-72. DOI: https://doi.org/10.1016/j.transproceed.2019.10.010
Gozen AS, Gherman V, Akin Y, et al. Evaluation of the complications in laparoscopic retroperitoneal radical nephrectomy; An experience of high volume centre. Arch Ital Urol Androl. 20171; 89:266-271. DOI: https://doi.org/10.4081/aiua.2017.4.266
Spampinato G, Binet A, Fourcade L, et al. Comparison of the learning curve for robot-assisted laparoscopic pyeloplasty between senior and junior surgeons. J Laparoendosc Adv Surg Tech A. 2021; 31:478-483. DOI: https://doi.org/10.1089/lap.2020.0822

How to Cite

Partezani, A. D., Duarte-Santos, H. O. ., Amaral, B. S., Gomes Barbosa, A. R. ., Apezzato, M. ., Brunhara, J. ., Bianco, B., Lemos, G. C., & Carneiro, A. (2022). Outcomes of nephrectomy for renal cell carcinoma: An ecologic retrospective study in a middle-income country. Archivio Italiano Di Urologia E Andrologia, 94(2), 129–133. https://doi.org/10.4081/aiua.2022.2.129