https://doi.org/10.4081/ijfs.2024.12725
Monitoring and preventing foodborne outbreaks: are we missing wastewater as a key data source?
Submitted: 16 June 2024
Accepted: 29 July 2024
Published: 10 October 2024
Accepted: 29 July 2024
Abstract Views: 36
PDF: 15
SUPPLEMENTARY MATERIAL: 6
SUPPLEMENTARY MATERIAL: 6
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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In 2022, the number of foodborne outbreaks in Europe increased by 43.9%, highlighting the need to improve surveillance systems and design outbreak predictive tools. This review aims to assess the scientific literature describing wastewater surveillance to monitor foodborne pathogens in association with clinical data. In the selected studies, the relationship between peaks of pathogen concentration in wastewater and reported clinical cases is described. Moreover, details on analytical methods to detect and quantify pathogens as well as wastewater sampling procedures are discussed. Few papers show a statistically significant correlation between high concentrations of foodborne pathogens in wastewater and the occurrence of clinical cases. However, monitoring pathogen concentration in wastewater looks like a promising and cost-effective strategy to improve foodborne outbreak surveillance. Such a strategy can be articulated in three steps, where the first one is testing wastewater with an untargeted method, like shotgun metagenomic, to detect microorganisms belonging to different domains. The second consists of testing wastewater with a targeted method, such as quantitative polymerase chain reaction, to quantify those specific pathogens that in the metagenomic dataset display an increasing trend or exceed baseline concentration thresholds. The third involves the integrated wastewater and clinical data analysis and modeling to find meaningful epidemiological correlations and make predictions.
Ahmed W, Bivins A, Bertsch PM, Bibby K, Gyawali P, Sherchan SP, Simpson SL, Thomas KV, Verhagen R, Kitajima M, Mueller JF, 2021. Intraday variability of indicator and pathogenic viruses in 1-h and 24-h composite wastewater samples: implications for wastewater-based epidemiology. Environ Res 193:110531.
DOI: https://doi.org/10.1016/j.envres.2020.110531
Calgua B, Mengewein A, Grunert A, Bofill-Mas S, Clemente-Casares P, Hundesa A, Wyn-Jones AP, López-Pila JM, Girones R, 2008. Development and application of a one-step low-cost procedure to concentrate viruses from seawater samples. J Virol Methods 153:79-83.
DOI: https://doi.org/10.1016/j.jviromet.2008.08.003
Chau KK, Barker L, Budgell EP, Vihta KD, Sims N, Kasprzyk-Hordern B, Harriss E, Crook DW, Read DS, Walker AS, Stoesser N, 2022. Systematic review of wastewater surveillance of antimicrobial resistance in human populations. Environ Int 162:107171.
DOI: https://doi.org/10.1016/j.envint.2022.107171
Diemert S, Yan T, 2019. Clinically unreported salmonellosis outbreak detected via comparative genomic analysis of municipal wastewater Salmonella isolates. Appl Environ Microbiol 85:e00139-19.
DOI: https://doi.org/10.1128/AEM.00139-19
EFSA, ECDC, 2023. The European Union One Health 2022 Zoonoses Report. EFSA J 21:e8442.
DOI: https://doi.org/10.2903/j.efsa.2023.8442
Farkas K, Marshall M, Cooper D, McDonald JE, Malham SK, Peters DE, Maloney JD, Jones DL, 2018. Seasonal and diurnal surveillance of treated and untreated wastewater for human enteric viruses. Environ Sci Pollut Res Int 25:33391-401.
DOI: https://doi.org/10.1007/s11356-018-3261-y
Fierer N, Holland-Moritz H, Alexiev A, Batther H, Dragone NB, Friar L, Gebert MJ, Gering S, Henley JB, Jech S, Kibby EM, Melie T, Patterson WB, Peterson E, Schutz K, Stallard-Olivera E, Sterrett J, Walsh C, Mansfeldt C, 2022. A metagenomic investigation of spatial and temporal changes in sewage microbiomes across a university campus. mSystems 7:e0065122.
DOI: https://doi.org/10.1128/msystems.00651-22
Garcia-Aljaro C, Blanch AR, Campos C, Jofre J, Lucena F, 2019. Pathogens, faecal indicators and human-specific microbial source-tracking markers in sewage. J Appl Microbiol 126:701-17.
DOI: https://doi.org/10.1111/jam.14112
Gibbons CL, Mangen MJJ, Plass D, Havelaar AH, Brooke RJ, Kramarz P, Peterson KL, Stuurman AL, Cassini A, Fèvre EM, Kretzschmar MEE, 2014. Measuring underreporting and under-ascertainment in infectious disease datasets: a comparison of methods. BMC Public Health 14:147.
DOI: https://doi.org/10.1186/1471-2458-14-147
Haagsma JA, Geenen PL, Ethelberg S, Fetsch A, Hansdotter F, Jansen A, Korsgaard H, O’Brien SJ, Scavia G, Spitznagel H, Stefanoff P, Tam CC, Havelaar AH, 2013. Community incidence of pathogen-specific gastroenteritis: reconstructing the surveillance pyramid for seven pathogens in seven European Union member states. Epidemiol Infect 141:1625-39.
DOI: https://doi.org/10.1017/S0950268812002166
Hellmér M, Paxéus N, Magnius L, Enache L, Arnholm B, Johansson A, Bergström T, Norder H, 2014. Detection of pathogenic viruses in sewage provided early warnings of hepatitis A virus and norovirus outbreaks. Appl Environ Microbiol 80:6771-81.
DOI: https://doi.org/10.1128/AEM.01981-14
Kazama S, Miura T, Masago Y, Konta Y, Tohma K, Manaka T, Liu X, Nakayama D, Tanno T, Saito M, Oshitani H, Omura T, 2017. Environmental surveillance of norovirus genogroups I and II for sensitive detection of epidemic variants. Appl Environ Microbiol 83:e03406-16.
DOI: https://doi.org/10.1128/AEM.03406-16
Kuhn KG, Shukla R, Mannell M, Graves GM, Miller AC, Vogel J, Malloy K, Deshpande G, Florea G, Shelton K, Jeffries E, De León KB, Stevenson B, 2023. Using wastewater surveillance to monitor gastrointestinal pathogen infections in the state of Oklahoma. Microorganisms 11:2193.
DOI: https://doi.org/10.3390/microorganisms11092193
La Rosa G, Della Libera S, Iaconelli M, Ciccaglione AR, Bruni R, Taffon S, Equestre M, Alfonsi V, Rizzo C, Tosti ME, Chironna M, Romanò L, Zanetti AR, Muscillo M, 2014. Surveillance of hepatitis A virus in urban sewages and comparison with cases notified in the course of an outbreak, Italy 2013. BMC Infect Dis 14:419.
DOI: https://doi.org/10.1186/1471-2334-14-419
Maida CM, Tramuto F, Giammanco GM, Palermo R, Priano W, De Grazia S, Purpari G, La Rosa G, Suffredini E, Lucentini L, Palermo M, Pollina Addario W, Graziano G, Immordino P, Vitale F, Sari Collaboration Group, Mazzucco W, 2023. Wastewater-based epidemiology as a tool to detect SARS-CoV-2 circulation at the community level: findings from a one-year wastewater investigation conducted in Sicily, Italy. Pathogens 12:748.
DOI: https://doi.org/10.3390/pathogens12060748
Mejias-Molina C, Pico-Tomas A, Beltran-Rubinat A, Martinez-Puchol S, Corominas L, Rusinol M, Bofill-Mas S, 2023. Effectiveness of passive sampling for the detection and genetic characterization of human viruses in wastewater. Environ Sci-Water Res Technol 9:1195-204.
DOI: https://doi.org/10.1039/D2EW00867J
Nattino G, Castiglioni S, Cereda D, Della Valle PG, Pellegrinelli L, Bertolini G, Pariani E, 2022. Association between SARS-CoV-2 viral load in wastewater and reported cases, hospitalizations, and vaccinations in Milan, March 2020 to November 2021. JAMA 327:1922-4.
DOI: https://doi.org/10.1001/jama.2022.4908
Nicolay N, Thornton L, Cotter S, Garvey P, Bannon O, McKeown P, Cormican M, Fisher I, Little C, Boxall N, De Pinna E, Peters T, Cowden J, Salmon R, Mason B, Irvine N, Rooney P, O'Flanagan D, 2011. Salmonella enterica serovar Agona European outbreak associated with a food company. Epidemiol Infect 139:1272-80.
DOI: https://doi.org/10.1017/S0950268810002360
Prado T, Rey-Benito G, Miagostovich MP, Sato MIZ, Rajal VB, Filho CRM, Pereira AD, Barbosa MRF, Mannarino CF, da Silva AS, 2022. Wastewater-based epidemiology for preventing outbreaks and epidemics in Latin America - lessons from the past and a look to the future. Sci Total Environ 865:161210.
DOI: https://doi.org/10.1016/j.scitotenv.2022.161210
Robins K, Leonard AFC, Farkas K, Graham DW, Jones DL, Kasprzyk-Hordern B, Bunce JT, Grimsley JMS, Wade MJ, Zealand AM, McIntyre-Nolan S, 2022. Research needs for optimising wastewater-based epidemiology monitoring for public health protection. J Water Health 20:1284-313.
DOI: https://doi.org/10.2166/wh.2022.026
Sala C, Mordhorst H, Grützke J, Brinkmann A, Petersen TN, Poulsen C, Cotter PD, Crispie F, Ellis RJ, Castellani G, Amid C, Hakhverdyan M, Le Guyader S, Manfreda G, Mossong J, Nitsche A, Ragimbeau C, Schaeffer J, Schlundt J, Tay MYF, Aarestrup FM, Hendriksen RS, Pamp SJ, De Cesare A, 2020. Metagenomics-based proficiency test of smoked salmon spiked with a mock community. Microorganisms 8:1861.
DOI: https://doi.org/10.3390/microorganisms8121861
Sarno E, Pezzutto D, Rossi M, Liebana E, Rizzi V, 2021. A review of significant European foodborne outbreaks in the last decade. J Food Prot 84:2059-70.
DOI: https://doi.org/10.4315/JFP-21-096
Swaan CM, Ouwerkerk IM van, Roest HJ, 2010. Cluster of botulism among Dutch tourists in Turkey, June 2008. Eurosurveillance 15:19532.
DOI: https://doi.org/10.2807/ese.15.14.19532-en
Tang Y, Liang Z, Li G, Zhao H, An T. 2021. Metagenomic profiles and health risks of pathogens and antibiotic resistance genes in various industrial wastewaters and the associated receiving surface water. Chemosphere 283:131224.
DOI: https://doi.org/10.1016/j.chemosphere.2021.131224
WHO, 2021. Estimating the burden of foodborne diseases: a practical handbook for countries. A guide for planning, implementing and reporting country-level burden of foodborne disease. Avaiable from: https://iris.who.int/bitstream/handle/10665/341634/9789240012264-eng.pdf?sequence=1.
Yan T, O’Brien P, Shelton JM, Whelen AC, Pagaling E, 2018. Municipal wastewater as a microbial surveillance platform for enteric diseases: a case study for Salmonella and salmonellosis. Environ Sci Technol 52:4869-77.
DOI: https://doi.org/10.1021/acs.est.8b00163
Yanagimoto K, Yamagami T, Uematsu K, Haramoto E, 2020. Characterization of Salmonella isolates from wastewater treatment plant influents to estimate unreported cases and infection sources of salmonellosis. Pathogens 9:52.
DOI: https://doi.org/10.3390/pathogens9010052
Zhang S, Shi J, Li X, Luby S, Coin L, O’Brien JW, Sivakumar M, Hai F, Jiang G, 2023. Triplex qPCR assay for Campylobacter jejuni and Campylobacter coli monitoring in wastewater. Sci Total Environ 892:164574.
DOI: https://doi.org/10.1016/j.scitotenv.2023.164574
Zhang S, Shi J, Sharma E, Li X, Gao S, Zhou X, O’Brien J, Coin L, Liu Y, Sivakumar M, Hai F, Jiang G, 2023. In-sewer decay and partitioning of Campylobacter jejuni and Campylobacter coli and implications for their wastewater surveillance. Water Res 233:119737.
DOI: https://doi.org/10.1016/j.watres.2023.119737
How to Cite
1.
Troja F, Indio V, Savini F, Seguino A, Serraino A, Fuschi A, Remondini D, De Cesare A. Monitoring and preventing foodborne outbreaks: are we missing wastewater as a key data source?. Ital J Food Safety [Internet]. 2024 Oct. 10 [cited 2024 Oct. 21];. Available from: https://www.pagepressjournals.org/ijfs/article/view/12725
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