https://doi.org/10.4081/aiua.2022.1.87

The use of a polyglycolic acid polymer graft in Peyronie’s disease - preliminary outcomes

Vol. 94 No. 1 (2022)
Submitted: December 21, 2021
Accepted: January 18, 2022
Published: March 29, 2022
Peyronie’s disease, Penile induration, Penile curvature, Erectile dysfunction, Bioabsorbable implants, Polyglycolic acid
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Authors

Pedro Caetano Edler Zandoná
uropedrozandona@gmail.com
Department of Urology of Hospital Governador Celso Ramos, Florianópolis, Brazil.
Nivio Pascoal Teixeira
Department of Urology of Hospital Governador Celso Ramos, Florianópolis, Brazil.
Henrique Eduardo Oliveira
Department of Urology of Hospital Governador Celso Ramos, Florianópolis, Brazil.
Jorge Hamilton Soares Garcia
Department of Anesthesiology of Hospital Governador Celso Ramos, Florianópolis, Brazil.

Objective: Plaque incision and grafting is indicated for patients with Peyronie’s Disease [PD] and severe curvature, complex deformities or for patients with significant penile shortening. To date, no graft studied has been considered ideal. The aim of this study is to conduct a descriptive analysis about functional results with the use of a bioabsorbable graft for PD treatment.
Materials and methods: A single-center, retrospective evaluation of a cohort of patients who were treated by plaque incision and grafting with a polyglycolic acid polymer graft (Gore® Bio-A®) between 2018 and 2021 was conducted. Correction of penile curvature was the main outcome. Loss of penile sensitivity, de novo erectile dysfunction and any other adverse event were the secondary endpoints.
Results: 14 patients were included in this study (mean age 59.5 ± 7.2 years). The median follow-up time was 12 months (range 3-12). The curvature correction rate was 78.5%. Glans hypoesthesia was present in one of 14 patients (7.1%) and refractory erectile dysfunction was reported in 64.2%. None of the patients presented any major adverse event based on Clavien-Dindo classification.
Conclusions: Curvature correction and changes in penile sensitivity rates were similar to those found in the literature. No major surgical complications, such as graft rejection, infection, and extrusion, occurred in this sample. Although a population with a higher prevalence of erectile dysfunction was included in this sample, higher rates of refractory erectile dysfunction were observed and these findings should be confirmed in further studies.

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Crossref
Scopus
Google Scholar
Europe PMC
Devine Jr CJ, Somers KD, Jordan SG, Schlossberg, SM. Proposal: trauma as the cause of the Peyronie’s lesion. J Urol. 1997; 157: 285. DOI: https://doi.org/10.1016/S0022-5347(01)65361-8
Kadioglu A, Tefekli A, Erol B, et al. A retrospective review of 307 men with Peyronie’s disease. J Urol. 2002; 168:1075. DOI: https://doi.org/10.1016/S0022-5347(05)64578-8
Rhoden EL, Riedner CE, Fuchs SC, et al. A cross-sectional study for the analysis of clinical, sexual and laboratory conditions associated to Peyronie’s disease. J Sex Med. 2010; 7:1529. DOI: https://doi.org/10.1111/j.1743-6109.2009.01584.x
Ralph D, Gonzalez-Cadavid N, Mirone V, et al. The management of Peyronie’s disease: evidence-based 2010 guidelines. J Sex Med, 2010. 7:2359. DOI: https://doi.org/10.1111/j.1743-6109.2010.01850.x
Chung E, Ralph D, Kagioglu A, et al. Evidence-based management guidelines on Peyronie’s disease. J Sex Med. 2016; 13:905. DOI: https://doi.org/10.1016/j.jsxm.2016.04.062
Mulhall J, Anderson M, Parker M. A surgical algorithm for men with combined Peyronie’s disease and erectile dysfunction: functional and satisfaction outcomes. J Sex Med. 2005; 2:132. DOI: https://doi.org/10.1111/j.1743-6109.2005.20113.x
Zaid UB, Alwaal A, Zhang X, Lue TF. Surgical management of Peyronie’s disease. Current Urol Rep. 2014; 15:446. DOI: https://doi.org/10.1007/s11934-014-0446-x
Garcia-Gomez B, Ralph D, Levine L, et al. Grafts for Peyronie's disease: a comprehensive review. Andrology. 2018; 6:117-126. DOI: https://doi.org/10.1111/andr.12421
Carson CC, Levine LA. Outcomes of surgical treatment of Peyronie's disease. BJU Int. 2014; 113:704-13. DOI: https://doi.org/10.1111/bju.12565
Schiffman ZJ, Gursel EO, Laor E. Use of Dacron patch graft in Peyronie disease. Urology. 1985; 25:38. DOI: https://doi.org/10.1016/0090-4295(85)90560-6
Faerber GJ, Konnak JW. Results of combined Nesbit penile plication with plaque incision and placement of Dacron patch in patients with severe Peyronie’s disease. J Urol. 1993; 149:1319. DOI: https://doi.org/10.1016/S0022-5347(17)36381-4
Klinge U, Schumpelick V, Klosterhalfen B. Functional assessment and tissue response of short- and long-term absorbable surgical meshes. Biomaterials. 2001; 22:1415. DOI: https://doi.org/10.1016/S0142-9612(00)00299-4
Yeo KK, Park TH, Park JH, et al. Histologic changes of implanted gore bio-a in an experimental animal model. Biomed Res Int. 2014; 2014:167962. DOI: https://doi.org/10.1155/2014/167962
Salonia A, Bettocchi C, Carvalho J, et al. Guidelines on Sexual and Reproductive Health. Edn. presented at the EAU Annual Congress Milan 2021. ISBN 978-94-92671-13-4.
Chung E, Clendinning E, Lessard L, Brock G. Five-year followup of Peyronie’s graft surgery: outcomes and patient satisfaction. J Sex Med. 2011; 8:594. DOI: https://doi.org/10.1111/j.1743-6109.2010.02102.x
Horstmann M, Kwol M, Amend B, et al. A self-reported longterm follow-up of patients operated with either shortening techniques or a TachoSil grafting procedure. Asian J Androl. 2011; 13:326. DOI: https://doi.org/10.1038/aja.2010.157
Sansalone S, Garaffa G, Djinovic R, et al. Long-term results of the surgical treatment of Peyronie’s disease with Egydio’s technique: a European multicentre study. Asian J Androl. 2011; 13:842. DOI: https://doi.org/10.1038/aja.2011.42
Terrier JE, Tal R, Nelson CJ, Mulhall JP. Penile Sensory Changes After Plaque Incision and Grafting Surgery for Peyronie’s Disease. J Sex Med. 2018; 15:1491. DOI: https://doi.org/10.1016/j.jsxm.2018.07.020
Fabiani A, Servi L, Fioretti F, et al. Buccal mucosa is a promising graft in Peyronie’s disease surgery. Our experience and a brief literature review on autologous grafting materials. Arch Ital Urol Androl. 2016; 88:115-21. DOI: https://doi.org/10.4081/aiua.2016.2.115
Fabiani A, Fioretti F, Pavia MP, et al. Buccal mucosa graft in surgical management of Peyronie's disease: Ultrasound features and clinical outcomes. Arch Ital Urol Androl. 2021; 93:107-110. DOI: https://doi.org/10.4081/aiua.2021.1.107
Trabuco EC, Zobitz ME, Klingele CJ, Gebhart JB. Effect of host response (incorporation, encapsulation, mixed incorporation and encapsulation, or resorption) on the tensile strength of graft-reinforced repair in the rat ventral hernia model. Am J Obstet Gynecol. 2007; 197: 638.e1. DOI: https://doi.org/10.1016/j.ajog.2007.08.049
Klinge U, Klosterhalfen B, Müller M, Schumpelick V. Foreign body reaction to meshes used for the repair of abdominal wall hernias. Eur J Surg. 1999; 165:665. DOI: https://doi.org/10.1080/11024159950189726
Revicki DA, Cella D, Hays RD, et al. Responsiveness and minimal important differences for patient reported outcomes. Health Qual Life Outcomes. 2006; 4:70. DOI: https://doi.org/10.1186/1477-7525-4-70

How to Cite

Edler Zandoná, P. C. ., Teixeira, N. P., Oliveira, H. E., & Soares Garcia, J. H. (2022). The use of a polyglycolic acid polymer graft in Peyronie’s disease - preliminary outcomes. Archivio Italiano Di Urologia E Andrologia, 94(1), 87–90. https://doi.org/10.4081/aiua.2022.1.87

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