https://doi.org/10.4081/aiua.2018.2.85

Resistance of uropathogens to antibacterial agents: Emerging threats, trends and treatments

Vol. 90 No. 2 (2018)
Submitted: April 11, 2018
Accepted: April 11, 2018
Published: June 30, 2018
Urinary tract infections, Resistance, Antibacterial agents, Antibiotics, Carbapenemase, Carbapenem resistance
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Authors

Gianpaolo Perletti
gianpaolo.perletti@uninsubria.it
Department of Biotechnology and Life Sciences, Section of Medical and Surgical Sciences, Università degli Studi dell'Insubria, Varese, Italy; Faculty of Medicine and Medical Sciences, Ghent University, Ghent, Belgium.
Vittorio Magri
Urology Secondary Care Clinic, ASST-Nord, Milan, Italy.
Tommaso Cai
Department of Urology, Santa Chiara Regional Hospital, Trento, Italy.
Konstantinos Stamatiou
Department of Urology, Tzaneio General Hospital of Piraeus, Piraeus, Greece.
Alberto Trinchieri
Urology Unit, A. Manzoni Hospital, Lecco, Italy.
Emanuele Montanari
Department of Urology, University of Milan - Ca' Granda Foundation - Ospedale Maggiore Policlinico, Milan, Italy.
Urinary tract infections are among the most common infectious diseases in humans. Today, resistance to nearly all antimicrobial classes is dramatically growing, and extremely drug-resistant or even pan-drug resistant pathogens are increasingly isolated around the world. It is foreseen that in the next decades the world will be facing a major medical emergency generated by the rapid spread of pathogens carrying resistance determinants of unprecedented power. Carbapenemase-producing Enterobacteriaceae, multidrug- resistant Enterococci and fluoroquinolone resistance determinants in both Gram-negative and Gram-positive uropathogens are among the greatest emergencies. In this article, the major emerging threats of particular interest to urologists are reviewed, worldwide resistance trends are illustrated, and novel and older – but still active – recommended drugs are summarized.

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How to Cite

Perletti, G., Magri, V., Cai, T., Stamatiou, K., Trinchieri, A., & Montanari, E. (2018). Resistance of uropathogens to antibacterial agents: Emerging threats, trends and treatments. Archivio Italiano Di Urologia E Andrologia, 90(2), 85–96. https://doi.org/10.4081/aiua.2018.2.85

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