How much does mitochondrial dysfunction affect male infertility?

Published: October 2, 2024
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Infertility is usually defined as the inability of a couple to conceive even after 1 year of unprotected, frequent sexual intercourse. The male is solely responsible in about 20% of cases. Several risk factors as well as urogenital abnormalities,endocrinological disease,enviromental toxines,genetic disorders,immunological factors,urogenitaly infections,sexual dysfunction  have been identified as causes of male infertility. Nowadays different studies reported mithocoldrial dysfunction as cause of male infertility and alteration of semen parameters.

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Leslie SW, Soon-Sutton TL, Khan MA. Male Infertility. In: StatPearls. Treasure Island: StatPearls Publishing; 2024. Available from: http://www.ncbi.nlm.nih.gov/books/NBK562258/
Park YJ, Lee BM, Pang WK, Ryu DY, et al. Low sperm motility is determined by abnormal protein modification during epididymal maturation. World J Mens Health. 2022;40:526. DOI: https://doi.org/10.5534/wjmh.210180
Park YJ, Pang MG. Mitochondrial functionality in male fertility: from spermatogenesis to fertilization. Antioxidants. 2021;10:98. DOI: https://doi.org/10.3390/antiox10010098
Shivaji S, Kota V, Siva AB. The role of mitochondrial proteins in sperm capacitation. J Reprod Immunol. 2009; 83:14-8. DOI: https://doi.org/10.1016/j.jri.2009.08.009
Freitas MJ, Vijayaraghavan S, Fardilha M. Signaling mechanisms in mammalian sperm motility. Biol Reprod. 2017;96:2-12.
Durairajanayagam D, Singh D, Agarwal A, Henkel R. Causes and consequences of sperm mitochondrial dysfunction. Andrologia. 2021;53:e13666. DOI: https://doi.org/10.1111/and.13666
Agarwal A, Virk G, Ong C, Du Plessis SS. Effect of oxidative stress on male reproduction. World J Mens Health. 2014;32:1. DOI: https://doi.org/10.5534/wjmh.2014.32.1.1
McLachlan RI, Kretser DM. Male infertility: the case for continued research: Even with modern assisted-reproduction technologies, clinical assessment and basic research on male infertility are essential. Med J Aust. 2001;174:116-7. DOI: https://doi.org/10.5694/j.1326-5377.2001.tb143180.x
Fusco GM, Cirillo L, Abate M, et al. Male infertility, what Mobile Health Applications “know”: quality analysis and adherence to European Association of Urology Guidelines. Arch Ital Urol Androl. 2022;94:470-5. DOI: https://doi.org/10.4081/aiua.2022.4.470
Pereira R, Sá R, Barros A, Sousa M. Major regulatory mechanisms involved in sperm motility. Asian J Androl. 2017; 19:5. DOI: https://doi.org/10.4103/1008-682X.167716
Wang JJ, Wang SX, Tehmina, et al. Age-related decline of male fertility: mitochondrial dysfunction and the antioxidant interventions. Pharmaceuticals. 2022; 15:519. DOI: https://doi.org/10.3390/ph15050519
Fusco F, Longo N, De Sio M, et al. Impact of circadian desynchrony on spermatogenesis: A mini review. Front Endocrinol (Lausanne). 2021;12:800693. DOI: https://doi.org/10.3389/fendo.2021.800693
Wang Y, Chen F, Ye L, et al. Steroidogenesis in Leydig cells: effects of aging and environmental factors. Reproduction. 2017; 154:R111-22. DOI: https://doi.org/10.1530/REP-17-0064
Ruiz-Pesini E, Lapeña AC, Díez-Sánchez C, et al. Human mtDNA haplogroups associated with high or reduced spermatozoa motility. Am J Hum Genet. 2000; 67:682-96. DOI: https://doi.org/10.1086/303040
Amaral A, Lourenço B, Marques M, Ramalho-Santos J. Mitochondria functionality and sperm quality. Reproduction. 2013; 146:R163-74. DOI: https://doi.org/10.1530/REP-13-0178
Kumar P, Sangeetha N. Mitochondrial DNA mutations and male infertility. Indian J Hum Genet. 2009; 15:93. DOI: https://doi.org/10.4103/0971-6866.60183
Ieremiadou F, Rodakis GC. Correlation of the 4977 bp mitochondrial DNA deletion with human sperm dysfunction. BMC Res Notes. 2009;2:18. DOI: https://doi.org/10.1186/1756-0500-2-18
Faja S, Nelson Darling L. Variation in restricted and repetitive behaviors and interests relates to inhibitory control and shifting in children with autism spectrum disorder. Autism. 2019; 23:1262-72. DOI: https://doi.org/10.1177/1362361318804192
Aitken ML, Limaye A, Pottinger P, et al. Respiratory outbreak of Mycobacterium abscessus subspecies massiliense in a Lung Transplant and Cystic Fibrosis Center. Am J Respir Crit Care Med. 2012;185:231-2. DOI: https://doi.org/10.1164/ajrccm.185.2.231
Tiwari S, Mohanty TK, Bhakat M, et al. Comparative evidence support better antioxidant efficacy of mitochondrial-targeted (Mitoquinone) than cytosolic (Resveratrol) antioxidant in improving in-vitro sperm functions of cryopreserved buffalo (Bubalus bubalis) semen. Cryobiology. 2021; 101:125-34. DOI: https://doi.org/10.1016/j.cryobiol.2021.04.007
El-Sherbiny HR, Abdelnaby EA, El-Shahat KH, et al. Coenzyme Q10 supplementation enhances testicular volume and hemodynamics, reproductive hormones, sperm quality, and seminal antioxidant capacity in goat bucks under summer hot humid conditions. Vet Res Commun. 2022; 46:1245-57. DOI: https://doi.org/10.1007/s11259-022-09991-8
Yang K, Wang N, Guo HT, et al. Effect of L-carnitine on sperm quality during liquid storage of boar semen. Asian-Australas J Anim Sci. 2020;33:1763-9. DOI: https://doi.org/10.5713/ajas.19.0455
Matta Reddy A, Iqbal M, Chopra H, et al. Pivotal role of vitamin D in mitochondrial health, cardiac function, and human reproduction. EXCLI J. 2022; 21:967-990.

How to Cite

Di Mauro, E., Cacace, G., Morgera, V., La Rocca, R., Napolitano, L., Saldutto, P., & Altieri, V. M. (2024). How much does mitochondrial dysfunction affect male infertility?. Archivio Italiano Di Urologia E Andrologia, 96(3). https://doi.org/10.4081/aiua.2024.12837