https://doi.org/10.4081/aiua.2024.12613

Kidney transplantation restores sex hormone profile and improves sexual function in ESRD patients with erectile dysfunction

Vol. 96 No. 3 (2024)
Submitted: April 27, 2024
Accepted: June 13, 2024
Published: October 2, 2024
Sex hormones profile, erectile dysfunction, kidney transplantation
Abstract Views: 122
PDF: 49
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Authors

Hany M. El Hennawy
hennawyhany@hotmail.com
Surgery Department, Section of Transplantation, Armed Forces Hospitals Southern Region, Khamis Mushayte, Saudi Arabia.
Omar Safar
https://orcid.org/0000-0001-8306-690X
Surgery Department, Section of Transplantation, Armed Forces Hospitals Southern Region, Khamis Mushayte, Saudi Arabia.
Abdullah S. Al Faifi
Surgery Department, Section of Transplantation, Armed Forces Hospitals Southern Region, Khamis Mushayte, Saudi Arabia.
Osama Shalkamy
https://orcid.org/0000-0003-1038-6464
Urology Department, Armed Forces Hospitals Southern Region, Khamis Mushayte, Saudi Arabia.
Mahmoud Z. El Madawie
Urology Department, Armed Forces Hospitals Southern Region, Khamis Mushayte, Saudi Arabia.
Saad Thamer
Urology Department, Armed Forces Hospitals Southern Region, Khamis Mushayte, Saudi Arabia.
Muath Almurayyi
Urology Department, Armed Forces Hospitals Southern Region, Khamis Mushayte, Saudi Arabia.
Abdullah Mohammed Alqarni
Laboratory Department, Armed Forces Hospitals Southern Region, Khamis Mushayte, Saudi Arabia.
Sami Saleh Amri
Laboratory Department, Armed Forces Hospitals Southern Region, Khamis Mushayte, Saudi Arabia.
Ali Abdullah Hawan
https://orcid.org/0000-0001-6639-5947
Laboratory Department, Armed Forces Hospitals Southern Region, Khamis Mushayte, Saudi Arabia.
Adel Elatreisy
https://orcid.org/0000-0001-8407-0564
Urology Department, Faculty of Medicine, Al Azhar University, Cairo, Egypt.

Background: Erectile dysfunction (ED) and sex hormone profile disturbances are common in ESRD patients. Objective: To assess the effect of kidney transplant (KT) and Hemodialysis/peritoneal dialysis (HD/PD) on the serum sex hormone profile and sexual functions in ESRD patients with ED.
Patients and methods: A single-center, nonconcurrent cohort study included a hundred ESRD patients with ED, on regular HD/PD (group A, n = 50) and after KT (group B, n = 50) at Armed Forces Hospitals Southern Region, KSA.
Results: the mean age of patients was 47.3 ± 7.01 and 56.8 ± 9.6 years in groups A and B, respectively. The cohorts were comparable regarding patient demographics, apart from a higher incidence of comorbidities in group B. After KT the mean testosterone level was higher in Group B (13.64 ± 3.21 nmol/L vs 10.26 ± 3.26 nmol/L, p < 0.001). Similarly, LH and prolactin levels were lower in group B than in group A (p < 0.05). As regards sexual function, ED was reported in 92% of patients in group A compared to 42% in group B (p < 0.001). In groups A and B, mild ED was found in 48% and 14% of patients, while moderate ED was found in 16% and 8%, respectively. The mean total IIEF-15 score was 36.42 ± 9.33 and 43.87 ± 9.146 in groups A and B, respectively (p = 0.0001). Sexual desire and orgasm were significantly better in Group B.
Conclusions: Our study showed that kidney transplantation could improve erectile function and restore normal sex hormone levels in ESRD male patients with ED, with better outcomes compared to HD/PD.

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Osama Shalkamy, Urology Department, Armed Forces Hospitals Southern Region, Khamis Mushayte

Urology Department, Faculty of Medicine, Al Azhar University, Cairo, Egypt

Adel Elatreisy, Urology Department, Faculty of Medicine, Al Azhar University, Cairo

Urology Department, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia

How to Cite

El Hennawy, H. M., Safar, O., Al Faifi, A. S., Shalkamy, O., El Madawie, M. Z., Thamer, S., Almurayyi, M., Alqarni, A. M., Amri, S. S., Hawan, A. A., & Elatreisy, A. (2024). Kidney transplantation restores sex hormone profile and improves sexual function in ESRD patients with erectile dysfunction. Archivio Italiano Di Urologia E Andrologia, 96(3). https://doi.org/10.4081/aiua.2024.12613
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