Does intravesical bacillus Calmette-Guérin for bladder cancer protect from COVID-19?

Submitted: March 4, 2024
Accepted: March 28, 2024
Published: May 9, 2024
Abstract Views: 658
PDF: 235
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Authors

Introduction: The study aimed to correlate the history of intravesical BCG as well as infantile BCG immunization with the incidence and severity of COVID-19 infection.
Methods: Retrospective data collection of patients with high-risk non muscle invasive bladder cancer (NMIBC) from two Canadian centers. Data collection included a history of BCG instillation, infantile immunization, and the development of COVID-19 infection. Admission and/or mortality because of COVID-19 was reported.
Results: We could include data from 348 patients: including 188 and 160 patients from Ontario and British Columbia respectively. COVID-19 affected 15% of these patients. Intravesical BCG was used in 44% of these patients. Intravesical BCG and/or infantile BCG immunization did not correlate with the incidence of COVID-19 infection.
Conclusions: Previous intravesical BCG and/ or a history of infantile BCG vaccination were not more/ less frequent in patients who had COVID-19 infection.

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Citations

Kaur G, Singh S, Nanda S, et al. Fiction and Facts about BCG Imparting Trained Immunity against COVID-19. Vaccines 2022;10:1006.
Gong W, Aspatwar A, Wang S, et al. COVID-19 pandemic: SARS-CoV-2 specific vaccines and challenges, protection via BCG trained immunity, and clinical trials. Expert Rev Vaccines 2021; 20:857-880.
Okafor CN, Rewane A, Momodu II. Bacillus Calmette Guerin. 2023 Jul 3. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024.
Koneru G, Batiha GE, Algammal AM, et al. BCG Vaccine-Induced Trained Immunity and COVID-19: Protective or Bystander? Infect Drug Resist. 2021; 14:1169-1184.
Miyasaka M. Is BCG vaccination causally related to reduced COVID-19 mortality? EMBO Mol Med. 2020; 12:e12661.
Saginala K, Barsouk A, Aluru JS, et al. Epidemiology of Bladder Cancer. Med Sci (Basel). 2020; 8:15.
Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (San Diego, Calif.), 2001; 25:402-408.
Gallegos H, Rojas PA, Sepúlveda F, et al. Protective role of intravesical BCG in COVID-19 severity. BMC Urology, 2021; 21:50.
van Puffelen JH, Novakovic B, van Emst L, et al. Intravesical BCG in patients with non-muscle invasive bladder cancer induces trained immunity and decreases respiratory infections. J Immunother Cancer. 2023; 11:e005518.
Pichler R, Diem G, Hackl H, et al. Intravesical BCG in bladder cancer induces innate immune responses against SARS-CoV-2. Front. Immunol. 2023; 14:1202157.
Miller A, Reandelar MJ, Fasciglione K, et al. (2020). Correlation between Universal BCG Vaccination Policy and Reduced Mortality for COVID-19. MedRxiv preprint doi: https://doi.org/10.1101/2020.03.24.20042937
World Health Organization (2020). Bacille Calmette-Guérin (BCG) vaccination and Covid-19. https://www.who.int/newsroom/commentaries/detail/bacille-calmette-gu%E9rin-(bcg)-vaccination-and-covid-19
Travassos TC, De Oliveira JMI, Selegatto IB, Reis LO. COVID-19 impact on bladder cancer-orientations for diagnosing, decision making, and treatment. Am J Clin Exp Urol. 2021; 9:132-139.

How to Cite

MacDonald, A., Bao, L., Mehrnoush, V., Ismail, A., Di Matteo, L., Zakaria, A., Elmansy, H., Black, P., & Kotb, A. (2024). Does intravesical bacillus Calmette-Guérin for bladder cancer protect from COVID-19?. Archivio Italiano Di Urologia E Andrologia, 96(2). https://doi.org/10.4081/aiua.2024.12449

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