https://doi.org/10.4081/aiua.2024.12387

Evaluating prognostic indicators for in-hospital mortality in Fournier's gangrene: a 7-year study in a tertiary hospital

Vol. 96 No. 2 (2024)
Submitted: February 14, 2024
Accepted: February 19, 2024
Published: May 30, 2024
Fournier's gangrene, indicator, neutrophil/lymphocyte ratio (NLR), platelet to lymphocit ratio
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Authors

Soetojo Wirjopranoto
stjowirjopranoto@gmail.com
Faculty of Medicine, Universitas Airlangga, Surabaya; Department of Urology, Faculty of Medicine, Universitas Airlangga- Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
Mohammad Reza Affandi
Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Faisal Yusuf Ashari
Faculty of Biology, Medicine and Health, University of Manchester, United Kingdom; Department of Biomedical Sciences, Faculty of Medicine Universitas Airlangga, Surabaya, Indonesia.
Yufi Aulia Azmi
https://orcid.org/0000-0002-9947-2432
Department of Health Sciences, University of Groningen, University Medical Center Groningen, Netherlands; Department of Urology, Faculty of Medicine, Universitas Airlangga- Dr. Soetomo General Academic Hospital, Surabaya, Indonesia.
Kevin Muliawan Soetanto
Department of Immunology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Background: Fournier's Gangrene Scoring Index (FGSI), Simplified FGSI (SFGSI), Uludag FGSI (UFGSI), Laboratory Risk Indicator for Necrotizing (LRINEC), Neutrophil-Lymphocyte ratio (NLR), and Platelet-lymphocyte ratio (PLR) have been devised to assess the risk of mortality in Fournier's Gangrene (FG) patients. However, the effectiveness of these indicators in predicting mortality at the time of admission remains uncertain. The aim of this study is to assess the prognostic efficacy of FG’s various indicators on in-hospital mortality.
Methods: This study analyzed 123 patients from Dr. Soetomo General Hospital’s emergency department in Indonesia from 2014 to 2020. Data included demographics, wound cultures, and parameters like FGSI, UFGSI, SFGSI, NLR, PLR, and LRINEC. In-hospital mortality status was also recorded. The data was subjected to comparative, sensitivity, specificity and regression analyses.
Results: In our study of 123 patients, the median age was 52, with a mortality rate of 17.9%. The majority of patients were male (91.1%) and the most common location was scrotal (54.5%). Non-survivors had a shorter median stay (6.5 days) compared to survivors (14 days). Diabetes was the most prevalent comorbidity (61.8%). The highest sensitivity and specificity were found in FGSI and UFGSI indicators. Multivariate logistic regression identified LoS and FGSI as independent predictors of mortality.
Conclusions: FGSI and UFGSI, upon admission, demonstrated the highest sensitivity and specificity, with hospital stay duration and FGSI as key mortality determinants.

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How to Cite

Wirjopranoto, S., Affandi, M. R., Ashari, F. Y., Azmi, Y. A., & Soetanto, K. M. (2024). Evaluating prognostic indicators for in-hospital mortality in Fournier’s gangrene: a 7-year study in a tertiary hospital. Archivio Italiano Di Urologia E Andrologia, 96(2). https://doi.org/10.4081/aiua.2024.12387
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