https://doi.org/10.4081/aiua.2024.12104

Revolutionizing localized prostate cancer treatment: Stereotactic radiotherapy “Moroccan experience”

Vol. 96 No. 1 (2024)
Submitted: November 17, 2023
Accepted: December 23, 2023
Published: February 16, 2024
Localized prostate cancer, stereotactic radiotherapy, toxicity, efficacy
Abstract Views: 333
PDF: 222
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Authors

Asmâa Naim
doc.a.naim@gmail.com
Faculty of Medicine, Mohammed VI University of Sciences and Health, Casablanca; Research Unit, Mohammed VI Center for Research and Innovation, Rabat; Radiotherapy Department of Casablanca Cancer Center, University International Hospital Cheikh Khalifa, Casablanca, Morocco.
Zineb Lahlou
Faculty of Medicine, Mohammed VI University of Sciences and Health, Casablanca; Research Unit, Mohammed VI Center for Research and Innovation, Rabat, Morocco.
Othmane Kaanouch
Radiotherapy Department of Casablanca Cancer Center, University International Hospital Cheikh Khalifa, Casablanca; Hassan First University of Settat, High Institute of Health Sciences, Laboratory of Sciences and Health Technologies, Settat, Morocco.
Abdelajalil Heddat
https://orcid.org/0000-0002-3725-9070
Faculty of Medicine, Mohammed VI University of Sciences and Health, Casablanca; Research Unit, Mohammed VI Center for Research and Innovation, Rabat; Urology Department, University International Hospital Cheikh Khalifa, Casablanca, Morocco.
Safae Mansouri
Faculty of Medicine, University Hassan II, Casablanca, Morocco.

Introduction: Prostate cancer is the most common urological cancer, and its incidence  is increasing. Radical prostatectomy and radiotherapy are theprimary treatments for localized forms. Stereotactic Body RadioTherapy (SBRT), a new and innovative therapy, has been validated for some cancer localizations but not yet for localized prostate cancer. Our study aims to report the efficacy and tolerance results of SBRT for localized prostate cancer.
Materials and methods: This is a retrospective study of 27 patients with localized prostate cancer (CaP) who were treated with SBRT in our department from 2017 to 2021 using transponders for tumor tracking. The dose was 36.25 Gy delivered in five fractions of 7.25 Gy. The delineation and doses of organs at risk were determined based on the recommendations of the SFRO and the TG101 report of medical physics. All patients were treated using a latest-generation linear accelerator (True Beam STXÒ).
Results: Acute toxicities were observed in 33.3% of cases, with 22.2% grade 1 or 2 genitourinary (GU) and no grade 3 while 11.1% gastrointestinal (GI) toxicities were reported as grade 1-2 (7.4%) and one case grade 3 (3.7%). Late grade 1 or 2 GU toxicity was observed in 14.84% of cases, with no reports of late GI toxicity. After a 26-month follow-up period, the biochemical failure-free survival rate was 92.6%.
Conclusions: The results of our study are consistent with the existing literature and support the safety and effectiveness of SBRT as a treatment option for localized prostate cancer (CaP). In the United States, both ASTRO and the NCCN recognize SBRT as a valid treatment option for localized CaP. Ongoing phase III trials are being conducted to further substantiate these long-term results and to establish SBRT as the future standard of care for localized CaP.

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How to Cite

Naim, A., Lahlou, Z., Kaanouch, O., Heddat, A., & Mansouri, S. (2024). Revolutionizing localized prostate cancer treatment: Stereotactic radiotherapy “Moroccan experience”. Archivio Italiano Di Urologia E Andrologia, 96(1). https://doi.org/10.4081/aiua.2024.12104
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