https://doi.org/10.4081/aiua.2023.11869

Relation between myostatin levels and malnutrition and muscle wasting in hemodialysis patients

Vol. 95 No. 4 (2023)
Submitted: September 23, 2023
Accepted: November 13, 2023
Published: December 20, 2023
Hemodialysis, Malnutrition, Muscle wasting, Myostatin
Abstract Views: 578
PDF: 282
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Authors

Amal H. Ibrahim
https://orcid.org/0000-0002-2786-7873
Department of Internal Medicine, Nephrology Unit, Al-Azhar University, Cairo, Egypt.
Sammar A. Kasim
Department of Internal Medicine, Nephrology Unit, Al-Azhar University, Cairo, Egypt.
Alshimaa A. Ezzat
https://orcid.org/0000-0002-5719-5182
Department of Radiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Noha E. Ibrahim
https://orcid.org/0000-0002-7176-4687
Department of Microbial Biotechnology, Biotechnology Research Institute, National Research Centre (NRC), Giza, Egypt.
Donia A. Hassan
https://orcid.org/0000-0002-3764-7647
Department of Clinical Pathology, Al-Azhar University, Cairo, Egypt.
Amira Sh. Ibrahim
https://orcid.org/0000-0002-0611-7360
Department of Rheumatology and Rehabilitation, Faculty of Medicine for girls, Al-Azhar University, Cairo, Egypt.
Tamer A. Abouelgreed
dr_tamer_ali@yahoo.com
https://orcid.org/0000-0003-2640-3425
Department of Urology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ehab M. Abdo
Department of Vascular Surgery, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Naglaa M. Aboelsoud
Department of Radiology, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Nermeen M. Abdelmonem
https://orcid.org/0009-0008-1026-6247
Department of Radiology, Thumbay University Hospital, Ajman, United Arab Emirates.
Mohammad Thabet Alnajem 
https://orcid.org/0009-0001-2934-2819
Department of Radiology, Tawam Hospital, Alain, United Arab Emirates.
Ahmed A. Aboomar
Department of internal medicine, Nephrology Unit, Faculty Medicine, Tanta University, Tanta, Egypt.

Background and aim: Malnutrition is one of the most troublesome comorbidities among hemodialysis patients (HD). Myostatin (MSTN) belongs to the transforming growth factor-β superfamily. In HD patients, MSTN effects are not limited to skeletal muscle growth. The present study aimed to assess MSTN levels in HD patients and its relation to various clinical and biochemical parameters. Patients and methods: The present case control study included 60 patients on HD for at least three years. In addition, there were age and sex-matched healthy subjects who constitutes the control group. Nutritional status was evaluated using the malnutrition inflammation score (MIS). Muscle wasting in the present study was evaluated using the lean tissue index (LTI) as assessed by the body composition monitor (BCM). Rectus Femoris Muscle (RFM) thickness was also measured as indicator for nutritional status of patient. Results: The present study included 60 HD patients, and ageand sex-matched healthy controls. Patients expressed significantly higher myostatin levels when compared to controls [median (IQR): 221.3 (153.5-688.2) versus 144.8 (97.0-281.7), p < 0.001]. According to MIS, patients were classified into those with no/mild malnutrition (n = 22) and others with moderate/severe malnutrition (n = 38). Comparison between the two subgroups revealed that the former group had significantly lower myostatin levels [167.7 (150.3-236.3) versus 341.7 (160.9-955.9), p = 0.004]. According to LTI, patients were classified into those with muscle wasting (n = 23) and others without muscle wasting (n = 37). Comparative analysis showed that patients in the former group had significantly higher myostatin levels [775.1 (325.1-2133.7) versus 161.8 (142.6-302.3), p < 0.001]. Conclusions: Myostatin seems to be a promising marker for identification of malnutrition and muscle wasting in HD patients.

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Naglaa M. Aboelsoud, Department of Radiology, Faculty of Medicine, Al-Azhar University, Cairo

  

Ahmed A. Aboomar, Department of internal medicine, Nephrology Unit, Faculty Medicine, Tanta University, Tanta

    

How to Cite

Ibrahim , A. H., Kasim, S. A., Ezzat , A. A., Ibrahim, N. E., Hassan, D. A., Ibrahim, A. S., Abouelgreed, T. A., Abdo, E. M., Aboelsoud, N. M., Abdelmonem, N. M., Alnajem , M. T., & Aboomar, A. A. (2023). Relation between myostatin levels and malnutrition and muscle wasting in hemodialysis patients. Archivio Italiano Di Urologia E Andrologia, 95(4). https://doi.org/10.4081/aiua.2023.11869
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