https://doi.org/10.4081/aiua.2023.11642

Treatment results of Para-Testicular Rhabdomyosarcoma (PT-RMS) using radiation as an alternative to retro-peritoneal nodal dissection: A single Institution experience

Vol. 95 No. 4 (2023)
Submitted: August 5, 2023
Accepted: August 31, 2023
Published: November 15, 2023
Para-testicular rhabdomyosarcoma, retro-peritoneal dissection, radiation therapy
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Authors

Yasser A. Abdelazim
yasser.anwar@nci.cu.edu.eg
https://orcid.org/0000-0001-7807-6978
Department of Radiation Oncology, National Cancer Institute, Cairo University, Egypt.
Monika F. Zaki
Department of Radiation Oncology, National Cancer Institute, Cairo University, Egypt.
Mohsen M. Abdel Mohsen
Department of Clinical Oncology, Faculty of medicine, Cairo University, Egypt.
Reem M. Emad
https://orcid.org/0000-0003-3457-8735
Department of Radiation Oncology, National Cancer Institute, Cairo University, Egypt.
Heba G. Mohamad
https://orcid.org/0000-0002-9412-0251
Department of Surgical Oncology, National Cancer Institute, Cairo University, Egypt.
Dalia Abdelfatah
https://orcid.org/0000-0002-8598-7128
Department of Cancer epidemiology & biostatistics. National Cancer Institute, Cairo University, Egypt.
Ehab M. Kalil
Department of Radiation Oncology, National Cancer Institute, Cairo University, Egypt.

Background: Para-testicular Rhabdomyosarcoma (PT-RMS) has a favorable treatment outcome adopting multidisciplinary management; resection, namely high inguinal orchiectomy ± retro-peritoneal lymph node dissection (RPLND) followed by standard or intensive chemotherapy ± adjuvant radiation therapy. Patients and methods: This is a retrospective study including all patients with pathologically proven PT-RMS, presented to the National Cancer Institute, Cairo University, during the period from 2005 to 2020. Endpoints included overall survival, disease free survival and patterns of failure of different treatment modalities. Results: Forty one patients were identified. Median age in our cohort was 15 years (range: 2-54 years). After a median follow up of 26 months (range, 3-75 months) ,two and five years OS were 100% and 91.7% respectively and median survival was not reached. Patients who underwent retro-peritoneal nodal dissection had a 5-year DFS rate of 100% versus 73% for those who received radiation to para-aortic nodes (p = 0.185). Limitations include retrospective nature and deviation from COG protocol. Conclusions: This study shows promising results suggesting that less aggressive local treatment modalities including radiation to para-aortic chain could be an option in PT-RMS, given the excellent results of this subtype. However further validation in a prospective study is warranted.

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How to Cite

Abdelazim, Y. A., Zaki, M. F., Abdel Mohsen, M. M., Emad, R. M., Mohamad, H. G., Abdelfatah, D., & Kalil, E. M. (2023). Treatment results of Para-Testicular Rhabdomyosarcoma (PT-RMS) using radiation as an alternative to retro-peritoneal nodal dissection: A single Institution experience. Archivio Italiano Di Urologia E Andrologia, 95(4). https://doi.org/10.4081/aiua.2023.11642
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