https://doi.org/10.4081/aiua.2022.4.455

Is there a difference in fecal microbiota of children with and without voiding dysfunction?

Vol. 94 No. 4 (2022)
Submitted: October 28, 2022
Accepted: November 6, 2022
Published: December 27, 2022
voiding dysfunction, Fecal microbiota, Fecal microbiota change
Abstract Views: 585
PDF: 278
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

ilker Akarken
Mugla Sıtkı Kocman University, School of Medicine, Department of Urology, Turkey.
Hüseyin Tarhan
drhuseyintarhan@gmail.com
Mugla Sıtkı Kocman University, School of Medicine, Department of Urology, Turkey.
Gamze Şener
Izmir Katip Celebi University, School of Medicine, Department of Microbiology, Turkey.
Hasan Deliktas
Mugla Sıtkı Kocman University, School of Medicine, Department of Urology, Turkey.
Nurcan Cengiz
Mugla Sıtkı Kocman University, School of Medicine, Department of Pediatric Nephrology, Turkey.
Hayrettin Şahin
Mugla Sıtkı Kocman University, School of Medicine, Department of Urology, Turkey.

Objective: Voiding dysfunction (VD), which encompasses many urinary symptoms that are not caused by neurological or anatomical anomalies, is a frequently encountered functional urinary bladder disorder in children. It was reported that there was an association between lower urinary tract symptoms and fecal microbiota in adult patients. Therefore, we aimed to investigate the differences in fecal microbiota between children with or without VD.
Methods: Two patient groups, including 30 patients, were compared. Group 1 included patients with VD, while Group 2 consisted of healthy children. All study participants were asked to fill lower urinary tract and voiding dysfunction symptom score forms with the assistance of their parents. Subsequently, uroflowmetry tests and postvoiding residual urine measurements were performed. Fresh stool samples were collected from all children and analyzed by polymerase chain reaction. General bacterial load and presence of Roseburia intestinalis, Clostridium difficile, Fusobacterium nucleatum, and Bacteroides clarus were tested.
Results: The two groups were significantly different regarding general bacterial load; the presence of Fusobacterium nucleatum. Clostridium difficile and Bacteroides clarus was not detected in the fresh stool samples of the patients in Group 2; the counts of Roseburia intestinalis were less in Group 1 than in Group 2, although there was no statistically significant difference. There was a negative correlation between symptom scores, general bacterial load, and the presence of Fusobacterium nucleatum. However, there was no correlation between the presence of Roseburia intestinalis and symptom scores.
Conclusions: There is a potential relationship between VD and a deviation in the fecal microbiota in the pediatric population.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Farhat W, Bägli Dj, Capolicchio G, O’reilly S, Merguerian Pa, Khoury A, et al. The dysfunctional voiding scoring system: quantitative standardization of dysfunctional voiding symptoms in children. The Journal of urology 2000;164:1011-5. DOI: https://doi.org/10.1097/00005392-200009020-00023
Austin PF, Bauer SB, Bower W, Chase J, Franco I, Hoebeke P, et al. The standardization of terminology of lower urinary tract function in children and adolescents: Update report from the standardization committee of the International Children's Continence Society. Neurourology and urodynamics 2016;35:471-81. DOI: https://doi.org/10.1002/nau.22751
Gill SR, Pop M, DeBoy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, et al. Metagenomic analysis of the human distal gut microbiome. science 2006;312:1355-9. DOI: https://doi.org/10.1126/science.1124234
Duvallet C, Gibbons SM, Gurry T, Irizarry RA, Alm EJ. Meta-analysis of gut microbiome studies identifies disease-specific and shared responses. Nature communications 2017;8:1-10. DOI: https://doi.org/10.1038/s41467-017-01973-8
Antunes-Lopes T, Vale L, Coelho AM, Silva C, Rieken M, Geavlete B, et al. The role of urinary microbiota in lower urinary tract dysfunction: a systematic review. European urology focus 2020;6:361-9. DOI: https://doi.org/10.1016/j.euf.2018.09.011
Akbal C, Genc Y, Burgu B, Ozden E, Tekgul S. Dysfunctional voiding and incontinence scoring system: quantitative evaluation of incontinence symptoms in pediatric population. The Journal of urology 2005;173:969-73. DOI: https://doi.org/10.1097/01.ju.0000152183.91888.f6
Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, et al. A human gut microbial gene catalogue established by metagenomic sequencing. nature 2010;464:59-65. DOI: https://doi.org/10.1038/nature08821
Pelzer E, Gomez-Arango LF, Barrett HL, Nitert MD. Maternal health and the placental microbiome. Placenta 2017;54:30-7. DOI: https://doi.org/10.1016/j.placenta.2016.12.003
Arrieta M-C, Stiemsma LT, Amenyogbe N, Brown EM, Finlay B. The intestinal microbiome in early life: health and disease. Frontiers in immunology 2014;5:427. DOI: https://doi.org/10.3389/fimmu.2014.00427
Yatsunenko T, Rey FE, Manary MJ, Trehan I, Dominguez-Bello MG, Contreras M, et al. Human gut microbiome viewed across age and geography. nature 2012;486:222-7. DOI: https://doi.org/10.1038/nature11053
Holland B, Karr M, Delfino K, Dynda D, El‐Zawahry A, Braundmeier‐Fleming A, et al. The effect of the urinary and faecal microbiota on lower urinary tract symptoms measured by the International Prostate Symptom Score: analysis utilising next‐generation sequencing. BJU international 2020;125:905-10. DOI: https://doi.org/10.1111/bju.14972
Braundmeier-Fleming A, Russell NT, Yang W, Nas MY, Yaggie RE, Berry M, et al. Stool-based biomarkers of interstitial cystitis/bladder pain syndrome. Scientific reports 2016;6:1-10. DOI: https://doi.org/10.1038/srep26083
Shoskes DA, Wang H, Polackwich AS, Tucky B, Altemus J, Eng C. Analysis of gut microbiome reveals significant differences between men with chronic prostatitis/chronic pelvic pain syndrome and controls. The Journal of urology 2016;196:435-41. DOI: https://doi.org/10.1016/j.juro.2016.02.2959
Okamoto T, Hatakeyama S, Imai A, Yamamoto H, Yoneyama T, Mori K, et al. Altered gut microbiome associated with overactive bladder and daily urinary urgency. World Journal of Urology 2021;39:847-53. DOI: https://doi.org/10.1007/s00345-020-03243-7
Yin J, Liao SX, He Y, Wang S, Xia GH, Liu FT, et al. Dysbiosis of gut microbiota with reduced trimethylamine‐N‐oxide level in patients with large‐artery atherosclerotic stroke or transient ischemic attack. Journal of the American Heart Association 2015;4:e002699. DOI: https://doi.org/10.1161/JAHA.115.002699
Carabotti M, Scirocco A, Maselli MA, Severi C. Erratum: The gut-brain axis: interactions between enteric microbiota, central and enteric nervous systems. Annals of Gastroenterology 2016.
Yang NJ, Chiu IM. Bacterial signaling to the nervous system through toxins and metabolites. Journal of molecular biology 2017;429:587-605. DOI: https://doi.org/10.1016/j.jmb.2016.12.023
Martin CR, Osadchiy V, Kalani A, Mayer EA. The brain-gut-microbiome axis. Cellular and molecular gastroenterology and hepatology 2018;6:133-48. DOI: https://doi.org/10.1016/j.jcmgh.2018.04.003
Davidson GL, Cooke AC, Johnson CN, Quinn JL. The gut microbiome as a driver of individual variation in cognition and functional behaviour. Philosophical Transactions of the Royal Society B: Biological Sciences 2018;373:20170286. DOI: https://doi.org/10.1098/rstb.2017.0286

How to Cite

Akarken, ilker, Tarhan, H., Şener, G., Deliktas, H., Cengiz, N., & Şahin, H. (2022). Is there a difference in fecal microbiota of children with and without voiding dysfunction?. Archivio Italiano Di Urologia E Andrologia, 94(4), 455–458. https://doi.org/10.4081/aiua.2022.4.455
Copyright (c) 2022 the Author(s) Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.