https://doi.org/10.4081/aiua.2022.4.443

Urinary epidermal growth factor and monocyte chemotactic protein-1 as biomarkers of renal injury in patients with obstructed nephropathy

Vol. 94 No. 4 (2022)
Submitted: October 27, 2022
Accepted: November 12, 2022
Published: December 27, 2022
Upper urinary tract obstruction, Urinary monocyte chemotactic protein-1 (uMCP-1), Urinary epidermal growth factor (uEGF)
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Authors

Eman M. El-Dydamony
Emanmohamed.8@azhar.edu.eg
Department of Urology, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Mohamed Ahmad Abdelaal
Department of Urology, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Sammar Ahmad Kasim
Department of Internal medicine, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Doaa Refaat Ameen
Department of Biochemistry, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.
Doaa Aly Abd El-Fattah
Department of Clinical Pathology, Faculty of Medicine (for Girls), Al-Azhar University, Cairo, Egypt.

Objective: To evaluate the role of urinary Monocyte Chemotactic Protein-1 (MCP1) and urinary epidermal growth factor (EGF) in diagnosing of upper urinary tract obstruction (UUTO).
Patient and methods: Over a period of 6 months (January 2022 to June 2022) this prospective case control comparative study was conducted on 120 participants, 60 of them with UUTO and 60 healthy controls. A morning urine sample of all participants was tested for EGF and MCP-1. after taking a detailed history taking and laboratory and radiological evaluation.
Results: Urinary MCP-1(uMCP-1) was significantly (p-value = 0.000) increased in UUTO group showing a mean ± SD of 518.10 ± 51.19 ng/L compared to a mean ± SD of 143.32 ± 58.03 ng/L in the controls, whereas a significantly (p-value = 0.000) decrease of urinary EGF (uEGF) was observed in patients with UUTO compared to control group. A significant difference of uEGF level and uEGF/uMCP1 ratio was observed between mild compared to moderate/severe UUTO.
Conclusions: Utilization of the urinary biomarker MCP1, EGF and uEGF/uMCP1 ratio in patients with UUTO can adequately be used as a simple, efficacious and noninvasive way in diagnosis of UUTO.

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How to Cite

El-Dydamony, E. M., Abdelaal, M. A., Kasim, S. A., Ameen, D. R., & El-Fattah, D. A. A. (2022). Urinary epidermal growth factor and monocyte chemotactic protein-1 as biomarkers of renal injury in patients with obstructed nephropathy. Archivio Italiano Di Urologia E Andrologia, 94(4), 443–446. https://doi.org/10.4081/aiua.2022.4.443
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