https://doi.org/10.4081/aiua.2022.4.428

AB0 blood groups and oncological and functional outcomes in bladder cancer patients treated with radical cystectomy

Vol. 94 No. 4 (2022)
Submitted: September 21, 2022
Accepted: October 2, 2022
Published: December 27, 2022
ABO, Blood groups, Bladder Cancer, Radical Cystectomy, Outcomes
Abstract Views: 612
PDF: 308
Supplementary Material: 50
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Alessandro Tafuri
aletaf@hotmail.it
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy; Department of Urology, “Vito Fazzi” Hospital, Lecce, Italy.
Andrea Panunzio
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy; Cancer and Prognostics Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Quebec, Canada.
Antonio Soldano
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Giovanni Mazzucato
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Paola Irene Ornaghi
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Giacomo Di Filippo
Department of General and Hepatobiliary Surgery, University of Verona, Azienda Ospedaliera Universitaria Integrata Verona, Verona, Italy.
Alessandra Gozzo
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Nicola De Maria
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Francesco Cianflone
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Aliasger Shakir
USC Institute of Urology, Catherine and Joseph Aresty Department of Urology, Keck School of Medicine, University of Southern California (USC), Los Angeles, United States.
Zhe Tian
Cancer and Prognostics Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Quebec, Canada.
Matteo Brunelli
Department of Pathology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Antonio Benito Porcaro
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Vincenzo Pagliarulo
Department of Urology, “Vito Fazzi” Hospital, Lecce, Italy.
Walter Artibani
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Pierre I. Karakiewicz
Cancer and Prognostics Health Outcomes Unit, Division of Urology, University of Montreal Health Center, Montreal, Quebec, Canada.
Alessandro Antonelli
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.
Maria Angela Cerruto
Department of Urology, University of Verona, Azienda Ospedaliera Universitaria Integrata di Verona, Verona, Italy.

Objectives: We investigated AB0 blood groups prevalence according to preoperative and pathological tumor characteristics, and their association with oncological outcomes, and renal function decline in a contemporary large cohort of bladder cancer (BCa) patients, who underwent radical cystectomy (RC) at a tertiary referral center.
Materials and Methods: We retrospectively evaluated data of patients with histologically confirmed and clinically non metastatic BCa, who underwent RC between 2014 and 2021 at our Institution. Kaplan-Meier (KM) plots and Cox regression (CR) models tested the relationship between AB0 blood groups and local recurrence-, metastasis-, cancer specific mortality-, and overall mortality-free survival. Logistic regression (LR) models tested the association between AB0 blood groups and renal function decline, defined as an estimated Glomerular Filtration Rate (eGFR) < 60 mL/min, at post-operative day 1, discharge and 6- months of follow-up.
Results: Of 301 included patients, 128 (42.5%) had group A, 126 (41.9%) had group 0, 28 (9.3%) had group B, and 19 (6.3%) had group AB. Patients with group 0 developed higher rates of muscle- invasive BCa (p = 0.028) with high-grade features (p = 0.005) at last bladder resection, and less frequently received preoperative immunotherapy with Bacillus of Calmette-Guerin (p = 0.044), than their non-0 counterparts. Additionally, these patients harbored more advanced pathologic tumor stage at RC (p = 0.024). KM plots showed no differences among all tested cancer control outcomes between AB0 blood groups (p > 0.05 in all cases). Patients with group AB presented the lowest median eGFR at each time point. In multivariable LR analyses addressing renal function decline, group AB was independently associated with eGFR< 60 mL/min at discharge (Odds Ratio: 4.28, p = 0.047).
Conclusions: Among AB0 blood groups, patients with group 0 exhibited the most aggressive tumor profile. However, no differences were recorded in recurrence or survival rates. Group AB independently predicted renal function decline at discharge.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2021. CA: a cancer journal for clinicians. 2021;71(1):7-33. DOI: https://doi.org/10.3322/caac.21654
Powles T, Bellmunt J, Comperat E, et al. Bladder cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up☆. Annals of Oncology. 2022;33(3):244-258. DOI: https://doi.org/10.1016/j.annonc.2021.11.012
van Hauen MB, Maibom SL, Thind PO, Martin Poulsen A, Joensen UN, Røder MA. Risk of recurrence and long-term mortality following radical cystectomy for bladder cancer. Scandinavian Journal of Urology. 2022/03/04 2022;56(2):149-154. DOI: https://doi.org/10.1080/21681805.2022.2028897
Zhan X, Jiang M, Deng W, Liu X, Chen L, Fu B. Development and Validation of a Prognostic Nomogram for Predicting Cancer-Specific Survival in Patients With Lymph Node Positive Bladder Cancer: A Study Based on SEER Database. Frontiers in Oncology. 2022;12:789028. DOI: https://doi.org/10.3389/fonc.2022.789028
Mir MC, Marchioni M, Zargar H, et al. Nomogram predicting bladder cancer–specific mortality after neoadjuvant chemotherapy and radical cystectomy for muscle-invasive bladder cancer: results of an international consortium. European urology focus. 2021;7(6):1347-1354. DOI: https://doi.org/10.1016/j.euf.2020.07.002
Bratu O, Marcu D, Anghel R, et al. Tumoral markers in bladder cancer. Experimental and therapeutic medicine. 2021;22(1):1-8. DOI: https://doi.org/10.3892/etm.2021.10205
Fujita N, Hatakeyama S, Okita K, et al. Impact of chronic kidney disease on oncological outcomes in patients with high-risk non-muscle-invasive bladder cancer who underwent adjuvant bacillus Calmette-Guérin therapy. Paper presented at: Urologic Oncology: Seminars and Original Investigations2021. DOI: https://doi.org/10.1016/j.urolonc.2020.06.032
Jiang DM, Gupta S, Kitchlu A, et al. Defining cisplatin eligibility in patients with muscle-invasive bladder cancer. Nature Reviews Urology. 2021;18(2):104-114. DOI: https://doi.org/10.1038/s41585-020-00404-6
Tafuri A, Odorizzi K, Di Filippo G, et al. Acute kidney injury strongly influences renal function after radical nephroureterectomy for upper tract urothelial carcinoma: A single-centre experience. Arch Ital Urol Androl. Mar 18 2021;93(1):9-14. DOI: https://doi.org/10.4081/aiua.2021.1.9
Leow JJ, Chong YL, Chang SL, Valderrama BP, Powles T, Bellmunt J. Neoadjuvant and Adjuvant Chemotherapy for Upper Tract Urothelial Carcinoma: A 2020 Systematic Review and Meta-analysis, and Future Perspectives on Systemic Therapy. Eur Urol. May 2021;79(5):635-654. DOI: https://doi.org/10.1016/j.eururo.2020.07.003
Tafuri A, Smith DD, Cacciamani GE, et al. Programmed Death 1 and Programmed Death Ligand 1 Inhibitors in Advanced and Recurrent Urothelial Carcinoma: Meta-analysis of Single-Agent Studies. Clin Genitourin Cancer. Oct 2020;18(5):351-360.e353. DOI: https://doi.org/10.1016/j.clgc.2020.01.004
Idris E, Tahir R, Amhamed A, Aboualkasem S. A Study on the Relationship between Blood Group and Type of Cancer. Scientific Journal for the Faculty of Science-Sirte University. 2022;2(1):23-27. DOI: https://doi.org/10.37375/sjfssu.v2i1.171
Wolpin BM, Chan AT, Hartge P, et al. ABO blood group and the risk of pancreatic cancer. J Natl Cancer Inst. Mar 18 2009;101(6):424-431. DOI: https://doi.org/10.1093/jnci/djp020
Gates MA, Xu M, Chen WY, Kraft P, Hankinson SE, Wolpin BM. ABO blood group and breast cancer incidence and survival. Int J Cancer. May 1 2012;130(9):2129-2137. DOI: https://doi.org/10.1002/ijc.26220
Wang Z, Liu L, Ji J, et al. ABO blood group system and gastric cancer: a case-control study and meta-analysis. Int J Mol Sci. Oct 17 2012;13(10):13308-13321. DOI: https://doi.org/10.3390/ijms131013308
Klatte T, Xylinas E, Rieken M, et al. Effect of ABO blood type on mortality in patients with urothelial carcinoma of the bladder treated with radical cystectomy. Urol Oncol. Jul 2014;32(5):625-630. DOI: https://doi.org/10.1016/j.urolonc.2013.11.010
Engel O, Soave A, Peine S, et al. The impact of the AB0 and the Rhesus blood group system on outcomes in bladder cancer patients treated with radical cystectomy. World J Urol. Nov 2015;33(11):1769-1776. DOI: https://doi.org/10.1007/s00345-015-1531-6
Gershman B, Moreira DM, Tollefson MK, et al. The association of ABO blood type with disease recurrence and mortality among patients with urothelial carcinoma of the bladder undergoing radical cystectomy. Urol Oncol. Jan 2016;34(1):4.e1-9. DOI: https://doi.org/10.1016/j.urolonc.2015.07.023
D'Andrea D, Moschini M, Soria F, et al. ABO Blood Group and Rhesus Factor Are Not Associated with Outcomes After Radical Cystectomy for Non-metastatic Urothelial Carcinoma of the Bladder. Anticancer Res. Oct 2017;37(10):5747-5753. DOI: https://doi.org/10.21873/anticanres.12014
Würdemann N, Wagner S, Sharma SJ, et al. Prognostic impact of AJCC/UICC 8th edition new staging rules in oropharyngeal squamous cell carcinoma. Frontiers in oncology. 2017;7:129. DOI: https://doi.org/10.3389/fonc.2017.00129
Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE. The 2016 WHO classification of tumours of the urinary system and male genital organs—part B: prostate and bladder tumours. European urology. 2016;70(1):106-119. DOI: https://doi.org/10.1016/j.eururo.2016.02.028
Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Annals of internal medicine. 2009;150(9):604-612. DOI: https://doi.org/10.7326/0003-4819-150-9-200905050-00006
Franchini M, Liumbruno GM. ABO blood group: old dogma, new perspectives. Clin Chem Lab Med. Aug 2013;51(8):1545-1553. DOI: https://doi.org/10.1515/cclm-2013-0168
Orntoft TF, Meldgaard P, Pedersen B, Wolf H. The blood group ABO gene transcript is down-regulated in human bladder tumors and growth-stimulated urothelial cell lines. Cancer Res. Mar 1 1996;56(5):1031-1036.
Hakomori S. Antigen structure and genetic basis of histo-blood groups A, B and O: their changes associated with human cancer. Biochim Biophys Acta. Dec 6 1999;1473(1):247-266. DOI: https://doi.org/10.1016/S0304-4165(99)00183-X
Cazzola P, Matturri L, Trinchieri A, et al. Impiego di una metodica di immunofluorescenza indiretta nella ricerca degli antigeni di superficie ABO (H) sulle cellule dell'epitelio di transizione. 1981.
Joh HK, Cho E, Choueiri TK. ABO blood group and risk of renal cell cancer. Cancer Epidemiol. Dec 2012;36(6):528-532. DOI: https://doi.org/10.1016/j.canep.2012.07.001
Porcaro AB, Amigoni N, Migliorini F, et al. ABO blood group system and risk of positive surgical margins in patients treated with robot-assisted radical prostatectomy: results in 1114 consecutive patients. J Robot Surg. Jun 29 2021. DOI: https://doi.org/10.1007/s11701-021-01267-8
Orihuela E, Shahon RS. Influence of blood group type on the natural history of superficial bladder cancer. J Urol. Oct 1987;138(4):758-759. DOI: https://doi.org/10.1016/S0022-5347(17)43363-5
Klatte T, Xylinas E, Rieken M, et al. Impact of ABO blood type on outcomes in patients with primary nonmuscle invasive bladder cancer. J Urol. May 2014;191(5):1238-1243. DOI: https://doi.org/10.1016/j.juro.2013.11.106
Jang AY, Seo J, Park YM, et al. ABO Blood Type Is Associated with Thrombotic Risk in Patients with Nonvalvular Atrial Fibrillation. J Clin Med. May 29 2022;11(11). DOI: https://doi.org/10.3390/jcm11113064
Neshat S, Rezaei A, Farid A, et al. Cardiovascular Diseases Risk Predictors: ABO Blood Groups in a Different Role. Cardiol Rev. Jun 9 2022. DOI: https://doi.org/10.1097/CRD.0000000000000463

How to Cite

Tafuri, A., Panunzio, A., Soldano, A., Mazzucato, G., Ornaghi, P. I., Di Filippo, G., Gozzo, A., De Maria, N., Cianflone, F., Shakir, A., Tian, Z., Brunelli, M., Porcaro, A. B., Pagliarulo, V., Artibani, W., Karakiewicz, P. I., Antonelli, A., & Cerruto, M. A. (2022). AB0 blood groups and oncological and functional outcomes in bladder cancer patients treated with radical cystectomy. Archivio Italiano Di Urologia E Andrologia, 94(4), 428–433. https://doi.org/10.4081/aiua.2022.4.428
Copyright (c) 2022 the Author(s) Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.