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In-vitro effects of PDE5 inhibitor and statin treatment on the contractile responses of experimental MetS rabbit's cavernous smooth muscle

Yasin Erden, Esat Korgalı, Gokce Dundar, Semih Ayan, Gökhan Gokce, Sahin Yildirim, Emin Yener Gultekin
  • Yasin Erden
    Cumhuriyet University School of Medicine Department of Urology, Turkey
  • Esat Korgalı
    Cumhuriyet University School of Medicine Department of Urology, Turkey | estkorgali@hotmail.com
  • Gokce Dundar
    Cumhuriyet University School of Medicine Department of Urology, Turkey
  • Semih Ayan
    Cumhuriyet University School of Medicine Department of Urology, Turkey
  • Gökhan Gokce
    Cumhuriyet University School of Medicine Department of Urology, Turkey
  • Sahin Yildirim
    Cumhuriyet University School of Medicine Department of Pharmachology, Turkey
  • Emin Yener Gultekin
    Cumhuriyet University School of Medicine Department of Urology, Turkey

Abstract

Objective: Hypercholesterolaemia promotes erectile dysfunction through increased superoxide formation and decreased nitric oxide bioactivity in cavernosal tissue. The role of nitric oxide on erectile function is well known. Statins have lipid lowering properties and can modulate endothelial nitric oxide bioavailability. Sildenafil, enhances smooth muscle relaxation in corpus cavernosum. We invastigated in-vitro effects of sildenafil and rosuvastatin on nonadrenergic, non-cholinergic and nitric oxide mediated cavernosal smooth musle relaxation in metabolic syndrome rabbits, since alterations in this pathway are recognised in diabetic and hypercholesterolemic erectile dysfunction. Methods: Ten male rabbits were fed a standart diet as control group, fourty male rabbits were fed a hypercholesterolemic diet for 12 weeks. Hypercholesterolemic group were divided for without treatment, rosuvastatin treatment, sildenafil teratment, and rosuvastatin + sildenafil treatment (N = 10 per groups). Results: Serum levels of cholesterol and glucose were significantly higher in the experimental group than in the control group (p < 0.05). After theraphy no differences were found among the groups in relaxation responses to sodium nitroprusside. The relaxation responses to carbachol and EFS were significantly reduced in metabolic syndrome group to control group (p < 0.05), but there were no differences between the other groups and control group. There was a significantly lower in-vitro relaxation response in the metabolic syndrome rabbits than in controls and the others (p < 0.05). Conclusion: Both agents improve in-vitro relaxation responses of erectile tissue from metabolic syndrome rabbits to endothelial non-adrenergic, non-cholinergic and nitric oxide. This finding supports to the results of other clinical studies with these drugs.

Keywords

Erectile dysfunction; Metabolic syndrome; Sildenafil; Rosuvastatin

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Submitted: 2014-03-28 10:51:59
Published: 2014-03-28 00:00:00
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Copyright (c) 2014 Yasin Erden, Esat Korgalı, Gokce Dundar, Semih Ayan, Gökhan Gokce, Sahin Yildirim, Emin Yener Gultekin

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