https://doi.org/10.4081/vl.2016.5764

Effective prophylaxis of visual and neurological disturbances with an anti-endothelin drug: analysis of 1642 sclerotherapy sessions

Vol. 5 No. 1 (2016): Cinderella indications for compression - International Compression Club (ICC) Meeting, 2015
Submitted: 21 January 2016
Accepted: 12 September 2016
Published: 7 December 2016
Chronic venous disease, foam sclerotherapy, endothelin 1, visual and neurological complications.
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Authors

Alessandro Frullini
info@venevaricose.it
Studio flebologico, Figline Incisa Valdarno (FI), Italy.
Angelo Guastini
Private practice, Chiavari (GE), Italy.
Demetrio Guarnaccia
Vascular Surgery, Clinica Santa Lucia, San Giuseppe vesuviano (NA), Italy.
O. Walter Loparco
Studio flebologico, Pescara, Italy.
Domenico Maurano
A.O. Cosenza, Italy.
Sabino Paradiso
Centro Medico Paradiso, Trani, Italy.
Antonio M. Previtera
Specialist in Angiology and Cardiology, Catania, Italy.
Michele Rendace
Vascular Surgery, A.S.P. Cosenza, Italy.
Serafino Viviani
Private practice, Castelnuovo Garfagnana (LU), Italy.
Patrizia Pavei
U.O.C. Day Surgery Multidisciplinare, A.O. Padova, Italy.
In the literature cases of stroke and transient neurological symptoms have been described after sclerotherapy for chronic venous disease The initial interpretation of these phenomena was that of a micro air embolism in association with a patent foramen ovale. This explanation did not always manage to justify all neurological manifestations. Recent theories have demonstrated that in the area of sclerosis, a significant amount of endothelin 1. We carried out a retrospective assessment of sclerotherapy case studies on 540 patients at ten phlebological centres to search for a relationship between the use of aminaftone (a venotropic drug with demonstrated anti-endothelin action) and the occurrence of side effects after sclerotherapy was performed. Significant reduction of side effects was observed in sclerotherapy for teleangectasias and in patients with migraine history.

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How to Cite

Frullini, A., Guastini, A., Guarnaccia, D., Loparco, O. W., Maurano, D., Paradiso, S., Previtera, A. M., Rendace, M., Viviani, S., & Pavei, P. (2016). Effective prophylaxis of visual and neurological disturbances with an anti-endothelin drug: analysis of 1642 sclerotherapy sessions. Veins and Lymphatics, 5(1). https://doi.org/10.4081/vl.2016.5764
Copyright (c) 2016 Alessandro Frullini, Angelo Guastini, Demetrio Guarnaccia, O. Walter Loparco, Domenico Maurano, Sabino Paradiso, Antonio M. Previtera, Michele Rendace, Serafino Viviani, Patrizia Pavei Creative Commons License

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