https://www.pagepressjournals.org/tmr/issue/feed 2023-10-27T12:44:05+00:00 Giulia Bertoni giulia.bertoni@pagepress.org Open Journal Systems <p><strong>Translational Medicine Reports</strong> is a peer-reviewed international journal publishing articles in the field of molecular biology, biochemistry and nanotechnology applied to the treatment of chronic-degenerative diseases including diabetes, cancer, neurological, cardiovascular and metabolic disorders. The aim of the Journal is to contribute to bridging the gap between basic research and clinical applications from an interdisciplinary perspective. <strong>Translational Medicine Reports</strong> addresses researchers and managers in academia, biotechnology and pharmaceutical industry researchers, physician scientists, <em>etc.</em> Original Articles with interdisciplinary topics, Reviews, Editorials, From Bench-to-Bedside Articles, Conference Proceedings, and Letters to the Editor are welcome. Every article published in the Journal will be peer-reviewed by experts in the field and selected by members of the Editorial Board. </p> <p><strong>The journal is completely free: no charge for publication, as it is supported by private funds.</strong></p> https://www.pagepressjournals.org/tmr/article/view/11506 2023-10-27T12:44:05+00:00 Elizabeth Shanahan elizabeth.grace.shanahan@gmail.com Christopher Mitchell cmitchmd@gmail.com Richard Chen r.chen331@gmail.com Steven Walsh stevenwalsh.md@gmail.com

<p>Minoxidil is a direct-acting vasodilator that induces relaxation of the vascular endothelium, and historically, it has been used as an antihypertensive agent. It caused hypertrichosis, resulting in its typical use today as an alopecia treatment. Toxicity is characterized by hypotension and tachycardia, often requiring treatment with α-adrenergic agonists. A previously healthy 18-year-old woman presented to the emergency department three hours after ingesting 60 mL of 5% W/V topical minoxidil solution. Initial vitals included sinus tachycardia at 117 beats per minute and a blood pressure of 92/44 mmHg. Laboratory analyses performed three hours post-ingestion revealed elevated aspartate and alanine aminotransferases (224 and 384 IU/L, respectively). Acetaminophen and ethanol concentrations were undetectable. Isotonic crystalloid, N-acetylcysteine, phenylephrine, and midodrine were administered. She developed pulmonary edema, requiring diuresis and supplemental oxygen <em>via</em> a nasal cannula. She was discharged 108 hours post-ingestion after a full recovery. Minoxidil toxicity may be an uncommon etiology of abnormal transaminase concentrations.</p>

2023-09-05T00:00:00+00:00 Copyright (c) 2023 Elizabeth Shanahan, Christopher Mitchell, Richard Chen, Steven Walsh