https://doi.org/10.4081/tmr.6596

Stealth liposomes for the delivery of zoledronic acid into tumors enhance the anticancer activity of the drug

Vol. 4 No. 1 (2020)
Submitted: 24 January 2017
Accepted: 24 February 2017
Published: 19 July 2017
Breast cancer, Drug delivery, Lung cancer, Stealth liposomes, Zoledronic acid
Abstract Views: 981
PDF: 549
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Authors

Silvia Zappavigna
silvia.zappa@libero.it
Department of Biochemistry, Biophysics and General Pathology, University of Campania L. Vanvitelli, Naples, Italy.
Amalia Luce
Department of Biochemistry, Biophysics and General Pathology, University of Campania L. Vanvitelli, Naples, Italy.
Manuela Porru
Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Rome, Italy.
Alessia M. Cossu
Department of Biochemistry, Biophysics and General Pathology, University of Campania L. Vanvitelli, Naples, Italy.
Carmela Ferri
Department of Biochemistry, Biophysics and General Pathology, University of Campania L. Vanvitelli, Naples, Italy.
Sara Lusa
Department of Pharmacy University of Naples "Federico II", Naples, Italy.
Marianna Abate
Department of Biochemistry, Biophysics and General Pathology, University of Campania L. Vanvitelli, Naples, Italy.
Giuseppe De Rosa
Department of Pharmacy, Federico II University of Naples, Naples, Italy.
Michele Caraglia
Department of Biochemistry, Biophysics and General Pathology, University of Campania L. Vanvitelli, Naples, Italy.
Carlo Leonetti
Experimental Chemotherapy Laboratory, Regina Elena Cancer Institute, Rome, Italy.
Zoledronic acid (ZOL) is a third generation aminobisphosphonate, commonly used for the treatment of bone metastases. Several studies have shown a direct in vitro antitumor activity of ZOL but a clear evidence of clinical activity is still lacking. Unfortunately, the use of ZOL as an anticancer agent in extraskeletal tissues is limited probably because it is rapidly removed from the blood and tends to accumulate in the bone. On these bases, we developed stealth liposomes encapsulating ZOL (Lipo- ZOL) to improve the pharmacokinetic profile of the drug. Compared to free ZOL, Lipo-ZOL induced a stronger inhibition of growth in two different cancer cell lines H460 and CG5. Moreover, Lipo-ZOL also significantly caused a larger inhibition of tumor growth and increased the overall survival in murine models of human lung and breast cancer, in comparison with free ZOL. These results suggest the use of Lipo-ZOL as a potential anticancer agent in patients with neoplastic disease.

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Silvia Zappavigna, Department of Biochemistry, Biophysics and General Pathology, University of Campania L. Vanvitelli, Naples

Assistant Professor, Department of Biochemistry, Biophysics and General Pathology

Second University of Naples

How to Cite

Zappavigna, S., Luce, A., Porru, M., Cossu, A. M., Ferri, C., Lusa, S., Abate, M., De Rosa, G., Caraglia, M., & Leonetti, C. (2017). Stealth liposomes for the delivery of zoledronic acid into tumors enhance the anticancer activity of the drug. Translational Medicine Reports, 4(1). https://doi.org/10.4081/tmr.6596
Copyright (c) 2017 Silvia Zappavigna, Amalia Luce, Manuela Porru, Alessia Maria Cossu, Carmela Ferri, Sara Lusa, Marianna Abate, Giuseppe De Rosa, Michele Caraglia, Carlo Leonetti Creative Commons License

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