https://doi.org/10.4081/mm.2017.6977

Rapid detection of cryptococcal antigen by a flow assay

Vol. 32 No. 3 (2017)
Submitted: 4 August 2017
Accepted: 5 September 2017
Published: 10 October 2017
Cryptococcosis, antigen, LFA
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Authors

Graziano Bargiggia
Microbiology and Virology Laboratory, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Silvia Corbellini
Microbiology and Virology Laboratory, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Gaia Ortalli
Microbiology and Virology Laboratory, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Fausto Moioli
Microbiology and Virology Laboratory, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Claudio Farina
cfarina@asst-pg23.it
http://orcid.org/0000-0003-2298-4293
Microbiology and Virology Laboratory, Papa Giovanni XXIII Hospital, Bergamo, Italy.
Cryptococcosis is a life-threatening infection caused by Cryptococcus neoformans and C. gattii. Tests for quick detection of the cryptococcal antigen are needed. This study compares the performance of a lateral flow assay (LFA) to the latex agglutination method. Thirty-five cryopreserved positive samples (sera and cerebrospinal fluids) plus three negative sera for control have been examined. LFA does not need high-temperature incubation or enzyme pre-treatment. All the results, except for one serum, agree with previous obtained with latex agglutination method. LFA has an important clinical utility for its rapidity and sensitivity, and it also can be used as a point-of-care test.

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How to Cite

Bargiggia, G., Corbellini, S., Ortalli, G., Moioli, F., & Farina, C. (2017). Rapid detection of cryptococcal antigen by a flow assay. Microbiologia Medica, 32(3). https://doi.org/10.4081/mm.2017.6977

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