https://doi.org/10.4081/mm.2015.4953

Evaluation of LIAISON® C. difficile glutamate dehydrogenase and LIAISON® C. difficile toxin A and B in Copan FecalSwabTM samples in a three-step algorithm for the diagnosis of Clostridium difficile infection

Vol. 30 No. 1 (2015)
Submitted: 12 January 2015
Accepted: 29 May 2015
Published: 18 June 2015
C. difficile, GDH, toxin A&B, chemiluminescence, 3 step algorithm, molecular, CDAD, immunochromatography
Abstract Views: 2010
PDF: 1017
HTML: 419
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Massimo Oggioni
massimo.oggioni@ospedaleniguarda.it
Chemical Clinical Analysis and Microbiology, Niguarda Ca’ Granda Hospital, Milan, Italy.
Alessandra Bielli
Chemical Clinical Analysis and Microbiology, Niguarda Ca’ Granda Hospital, Milan, Italy.
Alice Nava
Chemical Clinical Analysis and Microbiology, Niguarda Ca’ Granda Hospital, Milan, Italy.
Daniela Adele Pia Campisi
Chemical Clinical Analysis and Microbiology, Niguarda Ca’ Granda Hospital, Milan, Italy.
The presumptive laboratory diagnosis of Clostridium difficile infection is achieved by the means of the detection of a common antigen (glutamate dehydrogenase, GDH) in stool, then confirming the positives either by the detection of toxins A and B or by a molecular test for the detection of pathogenicity locus, encoding for the two toxins and for the binary toxin. A fully automated chemiluminescence system for the GDH antigen (LIAISON® C. difficile GDH) and for the detection of toxins A and B (LIAISON® C. difficile Toxin A and B) (DiaSorin, Gerenzano, Italy) allows for the performance of these tests on large numbers of samples in a short time, ensuring the traceability of the data.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC

How to Cite

Oggioni, M., Bielli, A., Nava, A., & Campisi, D. A. P. (2015). Evaluation of LIAISON® C. difficile glutamate dehydrogenase and LIAISON® C. difficile toxin A and B in Copan FecalSwabTM samples in a three-step algorithm for the diagnosis of Clostridium difficile infection. Microbiologia Medica, 30(1). https://doi.org/10.4081/mm.2015.4953

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.