https://doi.org/10.4081/mm.2024.12644
Respiratory viruses and SARS-CoV-2 virus circulation in the provinces of Lucca and Massa Carrara during the 2022/2023 and 2023/2024 flu seasons
Submitted: 7 May 2024
Accepted: 19 September 2024
Published: 20 November 2024
Accepted: 19 September 2024
Abstract Views: 337
PDF: 33
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Background and Aims: the study aimed to investigate the circulation of influenza viruses and SARS-CoV-2 in the 2022-23 and 2023-24 influenza seasons in the provinces of Lucca and Massa Carrara in the northwest of the Tuscany region.
Materials and Methods: a retrospective observational study was conducted on adult and pediatric patients who accessed hospital facilities in the considered area during the influenza periods (from September to April) of 2022-23 and 2023-24.
Results: the 2022-23 influenza season was characterized by the circulation of the A/H3N2 influenza virus (84% of the total), with a peak of positive samples from weeks 42 to 52 in 2022. Instead, the influenza A/(H1N1)pdm09 virus was responsible for 94% of influenza infections in the 2023-24 season, with a peak of positive samples between weeks 52 of 2023 and 3 of 2024.
Conclusions: effective virological diagnostics and constant monitoring of circulating viruses are mandatory to correctly address therapy and contain the viral circulation in the different influenza seasons.
Ali ST, Lau YC, Shan S, et al. Prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic: a modelling study. Lancet Glob Health 2022;10:e1612-22.
DOI: https://doi.org/10.1016/S2214-109X(22)00358-8
Antonovics J, Hood ME, Howell Baker C. Was the 1918 flu avian in origin? Nature 2006;34:440.
DOI: https://doi.org/10.1038/nature04824
Baselga-Moreno V, Trushakova S, McNeil S, et al. Influenza epidemiology and influenza vaccine effectiveness during the 2016-2017 season in the Global Influenza Hospital Surverillance Network (GIHSN). BMC Public Health 2019;19:487.
DOI: https://doi.org/10.1186/s12889-019-6713-5
Belshe RB. Implication of the emergence of a novel H1 influenza virus. N Engl J Med 2009;360:2667.
DOI: https://doi.org/10.1056/NEJMe0903995
Calabrò GE, Boccalini S, Bechini A, et al. Health Technology Assessment: a value-based tool for the evaluation of healthcare technologies. Reassessment of the cell-culture-derived quadrivalent influenza vaccine: Flucelvax Tetra® 2.0. J Prev Med Hyg 2022;63:E1-138.
Carrat F, Vergu E, Ferguson NM, et al. Time lines of infection and disease in human influenza: a review of volunteer challenge studies. Am J Epidemiol 2008;167:775-85.
DOI: https://doi.org/10.1093/aje/kwm375
Chowell G, Bertozzi SM, Colchero MA, et al. Severe respiratory disease cuncurrent with the circulation of H1N1 influenza. N Engl J Med 2009;361:679.
DOI: https://doi.org/10.1056/NEJMoa0904023
Cori A, Valleron AJ, Carrat F, et al. Estimating influenza latency and infections period durations using viral excretion data. Epidemics 2012;4:132-8.
DOI: https://doi.org/10.1016/j.epidem.2012.06.001
D’Angiolella LS, Lafranconi A, Cortesi PA, et al. Costs and effectiveness of influenza vaccination: A systematic review. Ann Ist Super Sanità 2018;54:49-57.
Daniels RS, McCauley JW. The health of influenza surveillance and pandemic preparedness in the wake of the COVID-19 pandemic. J Gen Virol 2023;104:001822.
DOI: https://doi.org/10.1099/jgv.0.001822
European Center for Disease Prevention and Control. Seasonal influenza. Available from: https://www.ecdc.europa.eu/en/seasonal-influenza
European Respiratory Virus Surveillance Summary (ERVISS). Overview of respiratory virus epidemiology in the EU/EEA. Available from: https://flunewseurope.org/
U. S. Food and Drug Administration (FDA). COVID-19 Test Basics. Available at: https://www.fda.gov/consumers/consumer-updates/covid-19-test-basics
Hadfield J, Megill C, Bell SM, et al. Nextstrain: real-time tracking of pahogen evolution. Bioinformatics 2018;34:4121-3.
DOI: https://doi.org/10.1093/bioinformatics/bty407
Istituto Superiore di Sanità (ISS). Epicentro. Available from: https://www.epicentro.iss.it
Istituto Superiore di Sanità (ISS). Epicentro. Influenza. Available from: https://www.epicentro.iss.it/influenza/
Istituto Superiore di Sanità (ISS). Rapporto InfluNet. Available from: https://www.iss.it/site/RMI/Influnet/pagine/rapportoInflunet.aspx
Jeong YJ, Wi YM, Park H, et al. Current and Emerging Knowledge in COVID-19. Radiology 2023;306:e222462.
DOI: https://doi.org/10.1148/radiol.222462
Lau MS, Cowling BJ, Cook AR, Riley S. Inferring influenza dynamics and control in households. Proc Natl Acad Sci USA 2015;112:9094-9.
DOI: https://doi.org/10.1073/pnas.1423339112
Ledesma J, Pozo F, Reina G, et al. Spanish Influenza Surveillance System (SiSS). J Clin Virol 2012;53:16-21.
DOI: https://doi.org/10.1016/j.jcv.2011.09.032
Lee J, Hadfield J, Black A, et al. Joint visualization of seasonal influenza serology and phylogeny to inform vaccine composition. Front Bioinform 2023;3:1069487.
DOI: https://doi.org/10.3389/fbinf.2023.1069487
Leung VKY, Wong JY, Barnes R, et al. Excess respiratory mortality and hospitalizations associated with influenza in Australia, 2007-2015. Int J Epidemiol 2022;51:458-67.
DOI: https://doi.org/10.1093/ije/dyab138
Li J, Shao TJ, Yu XF, et al. Molecular evolution of HA gene of the influenza A H1N1 pdm09 strain during the consecutive seasons 2009-2011 in Hangzhou, China: several immune-escape variants without positively selected sites. J Clin Virol 2012;55:363-6.
DOI: https://doi.org/10.1016/j.jcv.2012.08.006
Long QX, Liu BZ, Deng HJ, et al. Antibody responses to SARS-CoV-2 in patients with COVID-19. Nat Med 2020;26:845-8.
DOI: https://doi.org/10.1038/s41591-020-0897-1
Minh BQ, Schmidt HA, Chernomor O, et al. IQ-TREE 2: New Models and Efficiente Methods for Phylogenetic Inference in the Genomic Era. Molecular Biology and Evolution 2020;37:1530-4.
DOI: https://doi.org/10.1093/molbev/msaa015
Ministero della Salute. Influenza. Available from: https://www.salute.gov.it/portale/influenza/homeInfluenza.jsp
Ministero della Salute. Prevenzione e controllo dell’influenza: raccomandazioni per la stagione 2021-2022. 2021. Available from: https://www.quotidianosanita.it/allegati/allegato4210268.pdf
Ministero della Salute. Circolare “Indicazioni per l’effettuazione dei test diagnostici per SARS-CoV-2 per l’accesso e il ricovero nelle strutture sanitarie” del 15/12/2023. Available from: https://www.ordinemedicifc.it/2023/12/22/circolare-ministero-della-salute-39123-15-12-2023-recante-indicazioni-per-leffettuazione-dei-test-diagnostici-per-sars-cov-2-per-laccesso-e-il-ricovero-nelle-strutture-sanit/
Nishimura N, Nishio H, Lee MJ, Uemura K. The clinical features of RSV: lower respiratory tract infection after upper respiratory tract infection due to influenza virus. Ped International 2005;47:412-6.
DOI: https://doi.org/10.1111/j.1442-200x.2005.02099.x
Perz-Padilla R, de la Rosa-Zamboni D, Ponce de Leon S, et al. Pneumonia and respiratory failure from swine-origin influenza A(H1N1) in Mexico. N Engl J Med 2009;361:689.
DOI: https://doi.org/10.1056/NEJMoa0904252
Petrocelli PA, Cunsolo V, Melito M, et al. Diagnosis of Syncytial Respiratory Virus (RSV) infection in children by Respiratory Panel utilized during the Covid-19 pandemic. Ann Ist Super Sanità, 2023;59:31-6.
Puing-Barberà J, Natividad-Sancho A, Launay O, et al. 2012-2013 Seasonal influenza vaccine effectiveness against influenza hospitalizations: results from the global influenza hospital surveillance network. PloS One 2014;9:e100497.
DOI: https://doi.org/10.1371/journal.pone.0100497
Regione Toscana. Delibera n. 91 del 31 gennaio 2022. Revisione DGRT 945/2021 con approvazione delle “Linee di indirizzo per la gestione del prelievo e delle analisi dei test molecolari, dei test antigenici e dei test sierologici per la diagnosi e lo screening delle infezioni da SARS-CoV-2”. Revoca All. B della DGRT 945/2021. Available from: https://www301.regione.toscana.it/bancadati/atti/DettaglioAttiG.xml?codprat=2021DG00000001273
Stephenson E, Reynolds G, Botting RA, et al. Single-cell multi-omics analysis of the immune response in COVID-19. Nat Med 2021;27:904-16.
DOI: https://doi.org/10.1038/s41591-021-01329-2
Subbarao K, Matsuoka Y. The prospects and challenges of universal vaccines for influenza. Trends Microbiol 2013;21:350-8.
DOI: https://doi.org/10.1016/j.tim.2013.04.003
Sullivan SG, Carlson S, Cheng AC, et al. Where has all the influenza gone? The impact of COVID-19 on the circulation of influenza and other respiratory viruses, Australia, March to September 2020. Euro Surveill 2020;25:2001847.
DOI: https://doi.org/10.2807/1560-7917.ES.2020.25.47.2001847
Sullivan SG. Preparing for out-of-season influenza epidemics when international travel resumes. Med J Aust 2022;216:25-6.
DOI: https://doi.org/10.5694/mja2.51340
Thompson WW, Weintrauh E, Dhankhar P, et al. Estimates of US influenza-associated deaths made using four different methods. Influenza Other Respi Viruses 2009;3:37-49.
DOI: https://doi.org/10.1111/j.1750-2659.2009.00073.x
World Health Organization (WHO). Global Influenza Program – surveillance and monitoring. Available from: https://www.who.int/teams/global-influenza-programme/surveillance-and-monitoring/burden
World Health Organization (WHO). Global Influenza Surveillance and Response System (GISRS). Available from: https://www.who.int/initiatives/global-influenza-surveillance-and-response-system
World Health Organization (WHO). Influenza A(H1N2) variant virus infection - United Kingdom of Great Britain and Northern Ireland. 2023. Available from: https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON496
World Health Organization (WHO). Recommendations announced for influenza vaccine composition for the 2023-2024 northern hemisphere influenza season. 2023. Available from: https://www.who.int/news/item/24-02-2023-recommendations-announced-for-influenza-vaccine-composition-for-the-2023-2024-northern-hemisphere-influenza-season
World Health Organization (WHO). Recommended composition of influenza virus vaccines for use in the 2022 southern hemisphere influenza season. 2022. Available from: https://www.who.int/publications/m/item/recommended-composition-of-influenza-virus-vaccines-for-use-in-the-2022-southern-hemisphere-influenza-season
World Health Organization (WHO). Recommended composition of influenza virus vaccines for use in the 2023-2024 northern hemisphere influenza season. 2023. Available from: https://www.who.int/publications/m/item/recommended-composition-of-influenza-virus-vaccines-for-use-in-the-2023-2024-northern-hemisphere-influenza-season
Worobey M, Han GZ, Rambaut A. Genesis and pathogenesis of the 1918 pandemic H1N1 influenza A virus. Proceedings of the National Academy of Science of the United States of America 2014;111:8107-12.
DOI: https://doi.org/10.1073/pnas.1324197111
Zolotarova O, Budzanivska I, Leibenko L, et al. Antigenic Site Variation in the Hemagglutinin of Pandemic Influenza A(H1N1)pdm09 Viruses between 2009-2017 in Ukraine. Pathogens 2019:18;8:194.
DOI: https://doi.org/10.3390/pathogens8040194
How to Cite
Cunsolo, V., Petrocelli, P. A., Bianchimani, C., Sardone, L., Brucculeri, V., Baglini , D., Del Priore, S., Lattaro, V., Rossi, G., Nardone, M., & Rapi, S. (2024). Respiratory viruses and SARS-CoV-2 virus circulation in the provinces of Lucca and Massa Carrara during the 2022/2023 and 2023/2024 flu seasons. Microbiologia Medica, 39(2). https://doi.org/10.4081/mm.2024.12644
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