https://doi.org/10.4081/mm.2023.11517

Patterns of Mannose-Binding Lectin (MBL) responses to Plasmodium falciparum infections in hyperendemic settings

Vol. 38 No. 2 (2023)
Submitted: 12 June 2023
Accepted: 28 September 2023
Published: 7 December 2023
Plasmodium falciparum, Mannose-Binding Lectin, Interleukin 6, malaria
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Authors

Dia Aldeen Alfaki
dia-hassan@outlook.com
https://orcid.org/0000-0002-2314-2074
Department of Hematology, Alzaeim Al-Azhari University, Khartoum, Sudan.
Mohajir Hussein
Department of Microbiology, Alzaeim Al-Azhari University, Khartoum, Sudan.
Amanda G. Elgoraish
Department of Epidemiology, Tropical Medicine Research Institute NCR, Khartoum, Sudan.
Mohamed Mubarak Elbasheir
Department of Parasitology, Alzaeim Al-Azhari University, Khartoum, Sudan.

Background: malaria caused by Plasmodium falciparum remains a significant and major public health concern in Africa, particularly in hyperendemic regions. Recurrent fevers and high quantities of inflammatory mediators in the circulation define the disease's blood stages. By binding to non-self-pathogen oligosaccharide surfaces, Mannose-Binding Lectin (MBL) and lectin complement pathways trigger innate immune processes and contribute to the formation of adaptive immune responses. Methods: in Sudan, we investigated the varied immune response levels of MBL to the different phases of P. falciparum infection in White Nile and Blue Nile states endemic to malaria. And we looked at the interaction of regulatory Interleukin 6 (IL- 6) cytokines on MBL during infection. Our study was based on a total of 108 cases, in which 86 patients (62.0%) were uncomplicated and (17.6%) were severe, all met the diagnostic criteria and were clinically admitted for malaria infections. For the determination of serum MBL and IL-6 levels, a commercial ELISA kit was employed. Results: the analysis of the results revealed significantly elevated levels of MBL and IL-6 in both severe and uncomplicated cases (p<0.001). And MBL average in contrast to residents, Blue Nile patients had high parasitemia (599.9 ng/mL) and this difference was statistically significant (p-value<0.05). The remarkable positive correlation of IL-6 serum levels with MBL among malaria patients and healthy controls (r=0.399, p<0.001) was noted too. Conclusions: according to the findings of this study, patients living in hyperendemic areas exhibit a different MBL response rate and appear to be more homogeneous in proportion to the density of P. falciparum due to parasitemia. In addition, it is also dependent on the regulatory immune mediator IL-6.

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Crossref
Scopus
Google Scholar
Europe PMC
Abbas AK, Lichtman AH, Pillai S. Cellular and Molecular Immunology. 9th edition. Elsevier, Amsterdam, The Netherlands. 2017. 608 pp.
Akbari R, Mireskandari M, Alizadeh-Navaei R, Ghods A. Dialysis Measurement of Serum Levels of Mannose-binding Lectin in Hemodialysis Patients A Comparison With Healthy Individuals. Iranian Journal of Kidney Diseases 2011;5.
Alfaki DA, Mohamed Eisa I, Elbasheir MM, Humida ME. Monocytes to lymphocytes ratio in peripheral blood and immunoglobulin IgE levels as indicators to Plasmodium falciparum infection in Sudan. Journal of Bacteriology & Mycology: Open Access 2019;7. DOI: https://doi.org/10.15406/jbmoa.2019.07.00261
Andrade BB, Reis-Filho A, Souza-Neto SM, et al. Severe Plasmodium vivax malaria exhibits marked inflammatory imbalance. Malar J 2010;9:1-8. DOI: https://doi.org/10.1186/1475-2875-9-13
Antony JS, Ojurongbe O, Meyer CG, et al. Correlation of Interleukin-6 levels and lectins during Schistosoma haematobium infection. Cytokine. 2015;76:152-5. DOI: https://doi.org/10.1016/j.cyto.2015.04.019
Biryukov S, Stoute JA. Complement activation in malaria: Friend or foe? Trends in Molecular Medicine 2014;20:293-301. DOI: https://doi.org/10.1016/j.molmed.2014.01.001
Bouwman LH, Roep BO, Roos A. Mannose-binding lectin: clinical implications for infection, transplantation, and autoimmunity. Hum Immunol 2006;67:247-56. DOI: https://doi.org/10.1016/j.humimm.2006.02.030
Dalmon J, Laurent M, Courtois G. The human beta fibrinogen promoter contains a hepatocyte nuclear factor 1-dependent interleukin-6-responsive element. Mol Cell Biol 1993;13:1183-93. DOI: https://doi.org/10.1128/MCB.13.2.1183
Duan HO, Simpson-Haidaris PJ. Functional analysis of interleukin 6 response elements (IL-6REs) on the human gamma-fibrinogen promoter: binding of hepatic Stat3 correlates negatively with transactivation potential of type II IL-6REs. J Biol Chem 2003;278:41270-81. DOI: https://doi.org/10.1074/jbc.M304210200
Elhaj SAO, Abdrahim M, Elhassan MO. Prevalence of congenital malaria in Blue Nile state, Sudan. International Journal of Infectious Diseases 2016;45:296. DOI: https://doi.org/10.1016/j.ijid.2016.02.652
Fraser DA, Bohlson SS, Jasinskiene N, et al. C1q and MBL, components of the innate immune system, influence monocyte cytokine expression. J Leukoc Biol 2006;80:107-16. DOI: https://doi.org/10.1189/jlb.1105683
Garcia-Laorden MI, Sole-Violan J, de Castro FR, et al. Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults. J Allergy Clin Immunol 2008;122. DOI: https://doi.org/10.1016/j.jaci.2008.05.037
Garred P, Larsen F, Madsen HO, Koch C. Mannose-binding lectin deficiency - Revisited. Mol Immunol 2003;40:73-84. DOI: https://doi.org/10.1016/S0161-5890(03)00104-4
Garred P, Larsen F, Seyfarth J, et al. Mannose-binding lectin and its genetic variants. Genes Immun 2006;7:85-94. DOI: https://doi.org/10.1038/sj.gene.6364283
Garred P, Nielsen MA, Kurtzhals JAL, et al. Mannose-binding lectin is a disease modifier in clinical malaria and may function as opsonin for Plasmodium falciparum-infected erythrocytes. Infect Immun 2003;71:5245-53. DOI: https://doi.org/10.1128/IAI.71.9.5245-5253.2003
Garred P, Pressler T, Lanng S, et al. Mannose-binding lectin (MBL) therapy in an MBL-deficient patient with severe cystic fibrosis lung disease. Pediatr Pulmonol. 2002;33:201-7. DOI: https://doi.org/10.1002/ppul.10064
Götz A, Ty M, Chora AF, et al. Innate immunity to malaria. In: Malaria: Immune Response to Infection and Vaccination. Springer International Publishing, Berlin, Germany; 2017. DOI: https://doi.org/10.1007/978-3-319-45210-4_1
Holmberg V, Schuster F, Dietz E, et al. Mannose-binding lectin variant associated with severe malaria in young African children. Microbes Infect 2008;10:342-8. DOI: https://doi.org/10.1016/j.micinf.2007.12.008
Jacobson S, Larsson P, Åberg AM, et al. Levels of mannose-binding lectin (MBL) associates with sepsis-related in-hospital mortality in women. Journal of Inflammation (United Kingdom) 2020;17:28. DOI: https://doi.org/10.1186/s12950-020-00257-1
Kildey K, Rooks K, Weier S, et al. Effect of age, gender and mannose-binding lectin (MBL) status on the inflammatory profile in peripheral blood plasma of Australian blood donors. Hum Immunol 2014;75:973-9. DOI: https://doi.org/10.1016/j.humimm.2014.08.200
Klabunde J, Uhlemann AC, Tebo AE, et al. Recognition of Plasmodium falciparum proteins by mannan-binding lectin, a component of the human innate immune system. Parasitol Res 2002;88:113-7. DOI: https://doi.org/10.1007/s00436-001-0518-y
Koch A, Melbye M, Sørensen P, et al. Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood. JAMA 2001;285:1316-21. DOI: https://doi.org/10.1001/jama.285.10.1316
Luty AJF, Kun JFJ, Kremsner PG. Mannose-binding lectin plasma levels and gene polymorphisms in Plasmodium falciparum malaria. J Infect Dis 1998;178:1221-4. DOI: https://doi.org/10.1086/515690
Madsen HO, Garred P, Kurtzhals JAL, et al. A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein. Immunogenetics 1994;40:37-44. DOI: https://doi.org/10.1007/BF00163962
Malhotra R, Lu J, Holmskov U, Sim RB. Collectins, collectin receptors and the lectin pathway of complement activation. Clin Exp Immunol 1994;97:4. DOI: https://doi.org/10.1111/j.1365-2249.1994.tb06254.x
Naito H, Ikeda A, Hasegawa K, et al. Characterization of Human Serum Mannan-Binding Protein Promoter. J. Biochem 1999;126:1004-12. DOI: https://doi.org/10.1093/oxfordjournals.jbchem.a022543
Omer SA, Adam I, Noureldien A, et al. Congenital Malaria in Newborns Delivered to Mothers with Malaria-Infected Placenta in Blue Nile State, Sudan. J Trop Pediatr 2020;66:428-34. DOI: https://doi.org/10.1093/tropej/fmz083
Omer S, Franco-Jarava C, Noureldien A, et al. Impact of placental malaria on maternal, placental and fetal cord responses and its role in pregnancy outcomes in women from Blue Nile State, Sudan. Malar J 2021;20. DOI: https://doi.org/10.1186/s12936-021-03580-x
Reyburn H, Mbatia R, Drakeley C, et al. Association of Transmission Intensity and Age With Clinical Manifestations and Case Fatality of Severe Plasmodium falciparum Malaria. JAMA 2005;293:1461-70. DOI: https://doi.org/10.1001/jama.293.12.1461
Ringwald P, Peyron F, Vuillez JP, et al. Levels of cytokines in plasma during Plasmodium falciparum malaria attacks. J Clin Microbiol 1991;29:2076. DOI: https://doi.org/10.1128/jcm.29.9.2076-2078.1991
Stevenson MM, Riley EM. Innate immunity to malaria. Nature Reviews Immunology 2004;4:169-80. DOI: https://doi.org/10.1038/nri1311
Super M, Lu J, Thiel S, et al. Association of low levels of mannan-binding protein with a common defect of opsonisation. Lancet 1989;2:1236-9. DOI: https://doi.org/10.1016/S0140-6736(89)91849-7
Thiel S, Holmskov U, Hviid L, et al. The concentration of the C-type lectin, mannan-binding protein, in human plasma increases during an acute phase response. Clin Exp Immunol 1992;90:31-5. DOI: https://doi.org/10.1111/j.1365-2249.1992.tb05827.x
Thiel S, Steffensen R, Christensen IJ, et al. Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms. Genes Immun 2007;8:154-63. DOI: https://doi.org/10.1038/sj.gene.6364373
Turner MW. Mannose-binding lectin: the pluripotent molecule of the innate immune system. Immunol Today 1996 Nov;17:532-9. DOI: https://doi.org/10.1016/0167-5699(96)10062-1

How to Cite

Alfaki, D. A., Hussein, M., Elgoraish, A. G., & Elbasheir, M. M. (2023). Patterns of Mannose-Binding Lectin (MBL) responses to <i>Plasmodium falciparum</i> infections in hyperendemic settings. Microbiologia Medica, 38(2). https://doi.org/10.4081/mm.2023.11517
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