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Synergistic effect of clinically available β lactamases inhibitors on cefiderocol activity against carbapenemase producing Gram negative organisms

Authors

G. Bianco
Microbiology and Virology Unit , University Hospital Città della Salute e della Scienza di Torino, Turin; Department of Public Health and Paediatrics , University of Turin, Italy.
S. Comini
Microbiology and Virology Unit , University Hospital Città della Salute e della Scienza di Torino, Turin; Department of Public Health and Paediatrics , University of Turin, Italy.
P. Gaibani
Operative Unit of Microbiology , IRCCS Azienda Ospedaliero Universitaria di Bologna, Italy.
M. Boattini
Microbiology and Virology Unit , University Hospital Città della Salute e della Scienza di Torino, Turin; Department of Public Health and Paediatrics , University of Turin, Italy.
G. Banche
Department of Public Health and Paediatrics , University of Turin, Italy.
C. Costa
Microbiology and Virology Unit , University Hospital Città della Salute e della Scienza di Torino, Turin; Department of Public Health and Paediatrics , University of Turin, Italy.
P. Nordmann
Medical and Molecular Microbiology , Faculty of Science and Medicine, University of Fribourg, Fribourg; National Reference Center for Emerging Antibiotic Resistance (NARA), University of Fribourg , Fribourg, Switzerland.
R. Cavallo
Microbiology and Virology Unit , University Hospital Città della Salute e della Scienza di Torino, Turin; Department of Public Health and Paediatrics , University of Turin, Italy.

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Kazmierczak KM, Tsuji M, Wise MG, Hackel M, Yamano Y, Echols R, et al In vitro activity of cefiderocol a siderophore
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Karakonstantis S, Rousaki M, Kritsotakis EI Cefiderocol Systematic Review of Mechanisms of Resistance, Heteroresistance and In
Vivo Emergence of Resistance Antibiotics 2022;11:723. DOI: https://doi.org/10.3390/antibiotics11060723
The European Committee on Antimicrobial Susceptibility Testing Guidance document on broth microdilution testing of
cefiderocol 2020 Available at: http :://www eucast org
Doern CD When does 2 plus 2 equal 5 A review of antimicrobial synergy testing J Clin Microbiol 2014;52(4124):8. DOI: https://doi.org/10.1128/JCM.01121-14
NCCLS 1999 Methods for determining bactericidal activity of antimicrobial agents approved guideline Document M 26 A
National Committee for Clinical Laboratory Standards, Wayne, PA

How to Cite

Bianco, G., Comini, S., Gaibani, P., Boattini, M., Banche, G., Costa, C., Nordmann, P., & Cavallo, R. (2023). Synergistic effect of clinically available β lactamases inhibitors on cefiderocol activity against carbapenemase producing Gram negative organisms. Microbiologia Medica, 38(1). https://doi.org/10.4081/mm.2023.11367
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