Stillbirths’ microbiology: a favorable time for post-mortem microbiology

Published: 24 March 2023
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Post-Mortem Microbiology (PMM) aims to detect infections that could be a cause of stillbirth. A newborn having no sign of life after delivery is defined as stillbirth. Different infections could cause a chain of events leading to stillbirth but the relationships between maternal infection and stillbirth are often not very clear; as a matter of fact, the positive serologic tests do not prove causality. Screening, prevention, and treatment of maternal infections are important to reduce the stillbirth risk. The identification of an infectious agent that causes stillbirth through PMM is a shared aim by microbiologists, pathologists and surgeons, and it is also the common goal in clinical and forensic autopsies. The aim of this paper is a review the major infections that lead to stillbirths.

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Absalem, A. A., Alanazi, R. M., Alkhawajah, S. H. Rubella and Congenital Rubella Syndrome in Pediatric. The Egyptian Journal of Hospital Medicine 2017;69:2075-81. DOI: https://doi.org/10.12816/0041062
Ahmadal-Agroudi, M., Megahed, L., Abdallah, E., Morsy, T. A mini overview of malaria in pregnancy. Journal of the Egyptian Society of Parasitology 2017;47:177-96. DOI: https://doi.org/10.21608/jesp.2017.78027
Ahmed, R., Singh, N., terKuile, F. O., et al. Placental infections with histologically confirmed Plasmodium falciparum are associated with adverse birth outcomes in India: A cross-sectional study. Malaria Journal 2014;13:232. DOI: https://doi.org/10.1186/1475-2875-13-232
Arnaez, J., Ochoa-Sangrador, C., Caserío, S., et al. Lack of changes in preterm delivery and stillbirths during COVID-19 lockdown in a European region. European Journal of Pediatrics 2021;180:1997-2002. DOI: https://doi.org/10.1007/s00431-021-03984-6
Basso, N. G. S., Fonseca, M. E. F., Garcia, A. G. P., et al. Enterovirus isolation from fetal and placental tissues. Acta Virologica 1990;34:49-57.
Bunnell, M. E., Koenigs, K. J., Roberts, D. J., et al. Third trimester stillbirth during the first wave of the SARS-CoV-2 pandemic: Similar rates with increase in placental vasculopathic pathology. Placenta 2021;109:72-74. DOI: https://doi.org/10.1016/j.placenta.2021.04.003
Carlomagno, G., Luksa, V., Candussi, G., et al. Lyme Borrelia positive serology associated with spontaneous abortion in an endemic Italian area. Acta Europaea Fertilitatis 1988;19:279-81.
de Carvalho, A. L., Anchieta, L. M., Romanelli, R. M. de C. Congenital herpes virus infections. Revista Médica de Minas Gerais 2014;24. DOI: https://doi.org/10.5935/2238-3182.20140092
Chiba, M. E., Saito, M., Suzuki, N., et al. Measles infection in pregnancy. Journal of Infection, 2003;47:40-4. DOI: https://doi.org/10.1016/S0163-4453(03)00045-8
Cools, P. The role of Escherichia coli in reproductive health: state of the art. Research in Microbiology 2017;168:892-901. DOI: https://doi.org/10.1016/j.resmic.2017.02.002
Costache, M., Lazaroiu, A. M., Contolenco, A., et al. Clinical or postmortem? The importance of the autopsy; a retrospective study. Maedica 2014;9:261–5.
Crane, J., Mundle, W., Boucoiran, I., et al. Parvovirus B19 Infection in Pregnancy. Journal of Obstetrics and Gynaecology Canada 2014;36:1107-16. DOI: https://doi.org/10.1016/S1701-2163(15)30390-X
Di Gioia, C., Zullo, F., Bruno Vecchio, R. C., et al. Stillbirth and fetal capillary infection by SARS-CoV-2. American Journal of Obstetrics and Gynecology MFM 2022;4:100523. DOI: https://doi.org/10.1016/j.ajogmf.2021.100523
Di Maio, H. Listeria infection in women. Primary Care Update for Ob/Gyns, 2000;7:40-45. DOI: https://doi.org/10.1016/S1068-607X(99)00039-6
Enders, M., Weidner, A., Zoellner, I., et al. Fetal morbidity and mortality after acute human parvovirus B19 infection in pregnancy: Prospective evaluation of 1018 cases. Prenatal Diagnosis 2004;24:513-8. DOI: https://doi.org/10.1002/pd.940
Feist, H., Turowski, G., Hussein, K., et al. Massive Perivillous Fibrin Deposition of an Enterovirus A-Infected Placenta Associated With Stillbirth: A Case Report. Pediatric and Developmental Pathology 2019;22:142-5. DOI: https://doi.org/10.1177/1093526618798772
Fernandez-Rodriguez, A., Alberola, J., Cohen, M. C. Post-mortem microbiology analysis. Enfermedae Infecciosas Y MicrobiologiaClinica 2013;31:685–91. DOI: https://doi.org/10.1016/j.eimc.2012.09.019
Fernandez-Rodriguez, A., Cohen, M. C., Lucena, J., et al. How to optimise the yield of forensic and clinical post-mortem microbiology with an adequate sampling: a proposal for standardisation. European Journal of Clinical Microbiology & Infectious Diseases 2015;34:1045–57. DOI: https://doi.org/10.1007/s10096-015-2317-x
Gamboa-León, R., Ramirez-Gonzalez, C., Pacheco-Tucuch, F. S., et al. Seroprevalence of Trypanosoma cruzi among mothers and children in rural Mayan communities and associated reproductive outcomes. American Journal of Tropical Medicine and Hygiene 2014;91:348-53. DOI: https://doi.org/10.4269/ajtmh.13-0527
Gencay, M., Koskiniemi, M., Ämmälä, P., et al. Chlamydia trachomatis seropositivity is associated both with stillbirth and preterm delivery. APMIS 2000;108:584-8. DOI: https://doi.org/10.1034/j.1600-0463.2000.d01-101.x
Giambi, C., Filia, A., Rota, M. C., et al. Congenital rubella still a public health problem in Italy: Analysis of national surveillance data from 2005 to 2013. Eurosurveillance 2015;20. DOI: https://doi.org/10.2807/1560-7917.ES2015.20.16.21103
Goldenberg, R. L., McClure, E. M., Saleem, S., Reddy, U. M. Infection-related stillbirths. In The Lancet 2010;375:1482-90. DOI: https://doi.org/10.1016/S0140-6736(09)61712-8
Goldenberg, R. L., Thompson, C. The infectious origins of stillbirth. American Journal of Obstetrics and Gynecology 2003;189:861-73. DOI: https://doi.org/10.1067/S0002-9378(03)00470-8
Jaubert, J., Atiana, L., Larrieu, S., et al. Q fever seroprevalence in parturient women: The EQRUN cross-sectional study on Reunion Island. BMC Infectious Diseases 2020;20:261. DOI: https://doi.org/10.1186/s12879-020-04969-w
Kniffka, M. S., Nitsche, N., Rau, R., Kühn, M. Stillbirths in Germany: On the rise, but no additional increases during the first COVID-19 lockdown. International Journal of Gynecology and Obstetrics 2021;155:483-9. DOI: https://doi.org/10.1002/ijgo.13832
Krous, H. F., Langlois, N. E. Ljungan virus: A commentary on its association with fetal and infant morbidity and mortality in animals and humans. Birth Defects Research Part A - Clinical and Molecular Teratology 2010;88:947-52. DOI: https://doi.org/10.1002/bdra.20728
Lamond, N. M., Freitag, N. E. Vertical transmission of Listeria monocytogenes: Probing the balance between protection from pathogens and fetal tolerance. Pathogens 2018;7:52. DOI: https://doi.org/10.3390/pathogens7020052
Marks, S., Olenski, M. Q fever in the first trimester: A case report from northern rural New South Wales. Tropical Medicine and Infectious Disease 2019;4:90. DOI: https://doi.org/10.3390/tropicalmed4020090
Marwah, S., Jain, A., Dabral, A., Gupta, N. Stillbirth in COVID-19 Affected Pregnancies: A Double Whammy for the Mother. Cureus 2022;14:e22396. DOI: https://doi.org/10.7759/cureus.22396
Mboussou, Y., Jaubert, J., Larrieu, S., et al. Pregnancy outcomes of Q fever: Prospective follow-up study on Reunion Island. BMC Infectious Diseases 2019;19:1001. DOI: https://doi.org/10.1186/s12879-019-4619-6
McClure, E. M., Goldenberg, R. L. Infection and stillbirth. Seminars in Fetal and Neonatal Medicine 2009;14:182-9. DOI: https://doi.org/10.1016/j.siny.2009.02.003
McClure, E. M., Silver, R. M., Kim, J., et al. Maternal infection and stillbirth: a review. Journal of Maternal-Fetal and Neonatal Medicine 2022;35:4442-50. DOI: https://doi.org/10.1080/14767058.2020.1852206
McCurdy, W. C. Postmortem specimen collection. Forensic Science International 1987;35:61-5. DOI: https://doi.org/10.1016/0379-0738(87)90023-5
Mead, Z. M., Holden, S., Vadgama, B., et al. Post-mortem examinations in cases of stillbirth: is PM Microbiology Useful? Journal of Pathology 2013;231:48.
Meadow, S. R. Infectious Hepatitis and Stillbirth. British Medical Journal 1968;1:426. DOI: https://doi.org/10.1136/bmj.1.5589.426
Mithal, L. B., Otero, S., Simons, L. M., et al. Low-level SARS-CoV-2 viremia coincident with COVID placentitis and stillbirth. Placenta 2022;121:79-81. DOI: https://doi.org/10.1016/j.placenta.2022.03.003
Nan, C., Dangor, Z., Cutland, C. L., et al. Maternal group B Streptococcus-related stillbirth: A systematic review. BJOG 2015;122:1437-45. DOI: https://doi.org/10.1111/1471-0528.13527
Olaleye, A. O., Babah, O. A., Osuagwu, C. S., et al. Sexually transmitted infections in pregnancy – An update on Chlamydia trachomatis and Neisseria gonorrhoeae. European Journal of Obstetrics and Gynecology and Reproductive Biology 2020;255:1-12. DOI: https://doi.org/10.1016/j.ejogrb.2020.10.002
Omang, J., Ndep, A., Offiong, D., et al. Malaria in Pregnancy in Nigeria: A Literature Review. International Healthcare Research Journal 2020;3. DOI: https://doi.org/10.26440/IHRJ/0311.02315
Page, J. M., Varner, M. W., Dudley, D. J., et al. 863: Stillbirth cases associated with infection. American Journal of Obstetrics and Gynecology 2018;218. DOI: https://doi.org/10.1016/j.ajog.2017.11.400
Patra, S., Kumar, A., Trivedi, S. S., et al. Maternal and fetal outcomes in pregnant women with acute hepatitis E virus infection. Annals of Internal Medicine 2007;147:28-33. DOI: https://doi.org/10.7326/0003-4819-147-1-200707030-00005
Pérez-Gracia, M. T., Suay-García, B., Mateos-Lindemann, M. L. Hepatitis E and pregnancy: current state. In Reviews in Medical Virology 2007;27:28-33. DOI: https://doi.org/10.1002/rmv.1929
Petersson, K., Norbeck, O., Westgren, M., Broliden, K. Detection of parvovirus B19, cytomegalovirus and enterovirus infections in cases of intrauterine fetal death. Journal of Perinatal Medicine 2004;32:516-21. DOI: https://doi.org/10.1515/JPM.2004.128
Rawstron, S. A., Vetrano, J., Tannis, G., Bromberg, K. Congenital syphilis: Detection of Treponema pallidum in stillborns. Clinical Infectious Diseases 1997;24:24-7. DOI: https://doi.org/10.1093/clinids/24.1.24
Reekie, J., Roberts, C., Preen, D., et al. Chlamydia trachomatis and the risk of spontaneous preterm birth, babies who are born small for gestational age, and stillbirth: a population-based cohort study. The Lancet Infectious Diseases 2018;18:452-60. DOI: https://doi.org/10.1016/S1473-3099(18)30045-8
Rein, D. B., Stevens, G. A., Theaker, J., et al. The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology 2012;55:988-97. DOI: https://doi.org/10.1002/hep.25505
Roest, H. I. J., Bossers, A., van Zijderveld, F. G., Rebel, J. M. L. Clinical microbiology of coxiellaburnetii and relevant aspects for the diagnosis and control of the zoonotic disease Q fever. In Veterinary Quarterly 2013;33:148-60. DOI: https://doi.org/10.1080/01652176.2013.843809
Sahoo, P. K., Sabat, J., Shubhadra, S., et al. Burden of Rubella virus infection among females attending tertiary care hospitals of Odisha, India: a need for adult women vaccination. Human Vaccines and Immunotherapeutics 2021;17:3757-60. DOI: https://doi.org/10.1080/21645515.2021.1935168
Saxena, R., Bhatia, A., Midha, K., et al. Malaria: A Cause of Anemia and Its Effect on Pregnancy. World Journal of Anemia. Available from: https://www.wjoanemia.com/doi/WJOA/pdf/10.5005/jp-journals-10065-0012
Seale, A. C., Bianchi-Jassir, F., Russell, N. J., et al. Estimates of the burden of group b streptococcual disease worldwide for pregnant women, stillbirths, and children. Clinical Infectious Diseases. 2017;65:S200-19. DOI: https://doi.org/10.1136/archdischild-2018-rcpch.284
Segado-Arenas, A., Atienza-Cuevas, L., Broullon-Molanes, J. R., et al. Late stillbirth due to listeriosis. Autopsy and Case Reports 2018;8:e2018051. DOI: https://doi.org/10.4322/acr.2018.051
Shaapan, R. M. The common zoonotic protozoal diseases causing abortion. Journal of Parasitic Diseases 2016;40:1116-29. DOI: https://doi.org/10.1007/s12639-015-0661-5
Singh, A., Kumar, M. An Analysis of Cause of Stillbirth in a Tertiary Care Hospital of Delhi: A Contribution to the WHO SEARO Project. Journal of Obstetrics and Gynecology of India 2019;69:155-60. DOI: https://doi.org/10.1007/s13224-018-1161-1
Smith, B., Kemp, M., Ethelberg, S., et al. Listeria monocytogenes: Maternal-fetal infections in Denmark 1994-2005. Scandinavian Journal of Infectious Diseases 2009;41:21-5. DOI: https://doi.org/10.1080/00365540802468094
Stowe, J., Smith, H., Thurland, K., et al. Stillbirths during the COVID-19 Pandemic in England, April-June 2020. JAMA 2021;325:86-7. DOI: https://doi.org/10.1001/jama.2020.21369
Vázquez-Boland, J. A., Krypotou, E., Scortti, M. Listeria placental infection. mBio 2017;8:e00949-17. DOI: https://doi.org/10.1128/mBio.00949-17
Velavan, T. P., Pallerla, S. R., Johne, R., et al. Hepatitis E: An update on One Health and clinical medicine. Liver International 2021;41:1462-73. DOI: https://doi.org/10.1111/liv.14912
Vergani, P., Cozzolino, S., Pozzi, E., et al. Identifying the causes of stillbirth: a comparison of four classification systems. American Journal of Obstetrics and Gynecology 2008;199:319.e1-4. DOI: https://doi.org/10.1016/j.ajog.2008.06.098
Wylie, B. J., Rogerson, S. Malaria in pregnancy: Epidemiology , clinical manifestations , diagnosis, and outcome. Uptodate. 2020. Available at: https://www.uptodate.com/contents/malaria-in-pregnancy-epidemiology-clinical-manifestations-diagnosis-and-outcome
Xiong, Y. Q., Tan, J., Liu, Y-M., et al. The risk of maternal parvovirus B19 infection during pregnancy on fetal loss and fetal hydrops: A systematic review and meta-analysis. Journal of Clinical Virology 2019;114:12-20. DOI: https://doi.org/10.1016/j.jcv.2019.03.004
Zakama, A. K., Ozarslan, N., Gaw, S. L. Placental Malaria. Current Tropical Medicine Reports 2020;7:162-71. DOI: https://doi.org/10.1007/s40475-020-00213-2
Zheng, L., Wang, F., Huang, J., Xin, H. Evaluation of the association of zoonotic Ljungan virus with perinatal deaths and fetal malformation. Birth Defects Research Part C - Embryo Today: Reviews, 2015;105:81-5. DOI: https://doi.org/10.1002/bdrc.21093

How to Cite

Bonanno, R., Iacopino, O. S., Cucinotta, M., & d’Aleo, F. (2023). Stillbirths’ microbiology: a favorable time for post-mortem microbiology. Microbiologia Medica, 38(1). https://doi.org/10.4081/mm.2023.11025