https://doi.org/10.4081/mm.2023.10829

Prevalence of Herpes Simplex Virus Type-2 IgG Antibody among pregnant women in Port-Harcourt, Nigeria

Vol. 38 No. 1 (2023)
Submitted: 1 September 2022
Accepted: 10 January 2023
Published: 24 March 2023
Antibody, HSV-2, IgG, seropositivity, risk factors, pregnant women, Nigeria
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Authors

Iheanyi Omezuruike Okonko
iheanyi.okonko@uniport.edu.ng
Virus Research Unit, Department of Microbiology, University of Port Harcourt, Port Harcourt, Nigeria.
Amarachi Faith Benjamin
Department of Microbiology Technology, School of Science Laboratory Technology, University of Port Harcourt, Port Harcourt, Nigeria.
Tochi Ifeoma Cookey
Virus Research Unit, Department of Microbiology, University of Port Harcourt, Port Harcourt, Nigeria.
Blessing Jachinma Okonko
Virology & Immunology Research Unit, Department of Applied Microbiology, Ebonyi State University, Abakaliki, Nigeria.
Hope Innocent-Adiele
Virus Research Unit, Department of Microbiology, University of Port Harcourt, Port Harcourt, Nigeria.

Background and Aims: Herpes Simplex Type 2 Viruses (HSV- 2) are one of the most common viral sexually transmitted diseases worldwide, which are now a significant health concern. The most significant incidence of HSV infections occurs in women of reproductive age. Thus, the study aimed to ascertain the occurrence of HSV-2 IgG in pregnant women in Port Harcourt, Nigeria and identify the demographic profile associated with the prevalence. Materials and Methods: A hospital-based cross-sectional survey was adopted to randomly analyze 90 pregnant women attending antenatal clinics at a tertiary hospital in Port Harcourt, Nigeria. An enzyme-linked immunosorbent assay was used to assess HSV-2 IgG antibodies in the samples obtained. Results: Of the 90 subjects, 51.1% were HSV-2 seropositive, while 48.9% were seronegative for HSV-2 IgG antibody. No statistical association existed between the prevalence of HSV-2 IgG antibodies and the sociodemographic factors studied (p>0.05). Higher prevalence of HSV-2 IgG antibody mostly occurred in age 20-29 (54.2%), married (51.7%), no formal education (100.0%), unemployed and artisans (75.0%), Christians (53.1%), monogamous family type (52.0%), first trimester (62.5%), nulliparous (67.6%), abortion history (66.7%), history of Sexually Transmitted Diseases (STDs) (83.3%) and Human Immunodeficiency Virus (HIV) seropositive (100.0%). Conclusions: This study has confirmed that the prevalence of HSV-2 IgG antibodies among pregnant women in Port Harcourt, Nigeria is very high. The results indicate a considerable risk of primary or recurrent HSV infection during pregnancy, as shown by the prevalence rates. Identifying those at the highest risk is an appropriate initial step before the design of intervention strategies. Consequently, intervention strategies will be harnessed and implemented to reduce the risk of transmission to the fetus or newborn.

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Citations

Crossref
Scopus
Google Scholar
Europe PMC
Agyemang-Yeboah F, Debrah O, Donkoh ET, et al. Coinfection Prevalence of Herpes Simplex Virus Types 1 and 2 with Human Papillomavirus and Associated Risk Factors among Asymptomatic Women in Ghana, International Journal of Infectious Diseases and Therapy 2018;3:45-51. DOI: https://doi.org/10.11648/j.ijidt.20180303.11
Xu F, Sternberg MR, Kottiri BJ, et al. Trends in herpes simplex virus type 1 and type 2, seroprevalence in the United States. Journal of American Medical Association (JAMA) 2006;296:964-73. DOI: https://doi.org/10.1001/jama.296.8.964
Mbps-Keou FX, Robinson NJ, Mayaud P, et al. Herpes simplex virus type 2 and heterosexual spread of human immunodeficiency virus infection in developing countries: hypothesis and research priorities. Clinical Microbiology and Infectious Disease 2003;9:161-71. DOI: https://doi.org/10.1046/j.1469-0691.2003.00550.x
Celum CL. The Interaction between Herpes Simplex Virus and Human Immunodeficiency Virus. Herpes, 2004;11:36A-45A.
Looker KJ, Garnett GP, Schmid GP. An estimate of the global prevalence and incidence of herpes simplex virus type 2 infection. Bulletin of World Health Organization 2008;86:805-12. DOI: https://doi.org/10.2471/BLT.07.046128
Krebs JM. Understanding herpes simplex virus: transmission, diagnosis, and considerations in pregnancy management. Journal of Midwifery and Women's Health 2008;53:202-8. DOI: https://doi.org/10.1016/j.jmwh.2008.01.010
Baker DA. Consequences of herpes simplex virus in pregnancy and their prevention. Current Opinions in Infectious Diseases 2007;20:73-6. DOI: https://doi.org/10.1097/QCO.0b013e328013cb19
Sauerbrei A, Wutzler P. Herpes simplex and varicella-zoster virus infections during pregnancy: current concepts of prevention, diagnosis and therapy. Part 1: herpes simplex virus infections. Medical Microbiology and Immunology 2007;196:89-94. DOI: https://doi.org/10.1007/s00430-006-0031-0
Rathore S, Jamwal A, Gupta V. Herpes simplex virus type 2: Seroprevalence in antenatal women. Indian Journal of Sexually Transmitted Diseases 2010;31:11-15. DOI: https://doi.org/10.4103/0253-7184.68994
Mindel A, Taylor J, Tideman RL et al. Neonatal herpes prevention: a minor public health problem in some communities. Sexual Transmitted Infections 2000;76:287-9. DOI: https://doi.org/10.1136/sti.76.4.287
Dhoha EEE, Abbas BMR, Elgaili AE, Wafa IE. Seroprevalence of Herpes Simplex Virus Type 1 among Pregnant Women Attending Abo Gota Antenatal Care Clinic, AlGezira State, Sudan. International Journal of Advances in Pharmacy, Biology and Chemistry (IJAPBC) 2016;5:93-9.
Whitley RJ, Roizman B. Herpes simplex viruses. Lancet 2001;357:1513-8. DOI: https://doi.org/10.1016/S0140-6736(00)04638-9
Money D, Steben M. Guidelines for the management of herpes simplex virus in pregnancy. International Journal of Gynecology & Obstetrics 2009;104:167–71. DOI: https://doi.org/10.1016/j.ijgo.2008.10.028
Anzivino E, Fioriti D, Mischitelli M, et al. Herpes simplex virus infection in pregnancy and in neonate: status of art of epidemiology, diagnosis, therapy and prevention. Virology Journal 2009;6:40-6. DOI: https://doi.org/10.1186/1743-422X-6-40
Straface G, Selmin A, Zanardo V, et al. Herpes Simplex Virus Infection in Pregnancy. Infectious Disease Obstetrics and Gynecology 2012;2012:385697. DOI: https://doi.org/10.1155/2012/385697
Centers for Disease Control and Prevention. Sexually transmitted disease guidelines. 2006. Available from: www.cdc.gov/std/treatment/2006/rr5511.pdf
Chen KT, Segú M, Lumey LH, et al. New York City Perinatal AIDS Collaborative Transmission Study (PACTS) Group. Genital herpes simplex virus infection and perinatal transmission of human immunodeficiency virus. Obstetrics and Gynecology 2005;106:1341-8. DOI: https://doi.org/10.1097/01.AOG.0000185917.90004.7c
Charan J, Biswas T. How to calculate sample size for different study designs in medical research? Indian Journal of Psychological Medicine 2013;35:121–6. DOI: https://doi.org/10.4103/0253-7176.116232
Weiss H. Epidemiology of herpes Simplex Virus Type-2 infections in the developing world. Herpes 2004;11:24A-35A.
Corey L, Handsfield HH. Genital herpes and public health: Addressing a global problem. Journal of American Medical Association (JAMA) 2000;283:791-4. DOI: https://doi.org/10.1001/jama.283.6.791
Agabi YA, Banwat EB, Mawak JD, et al. Seroprevalence of herpes simplex virus type-2 among patients attending the Sexually Transmitted Infections Clinic in Jos, Nigeria. Journal of Infections in Developing Countries 2010;4:572-5. DOI: https://doi.org/10.3855/jidc.567
Okonko IO, Cookey TI. Seropositivity and determinants of immunoglobulin-G (IgG) antibodies against Herpes simplex virus (HSV) types -1 and -2 in pregnant women in Port Harcourt, Nigeria. African Health Sciences 2015;15:737-47. DOI: https://doi.org/10.4314/ahs.v15i3.6
Ghazi HO, Telmesani AM, Mahomed MF. TORCH agents in pregnant Saudi women. Medical Principles and Practices 2002;11:180-2. DOI: https://doi.org/10.1159/000065813
Sauerbrei A, Schmitt S, Scheper T, et al. Seroprevalence of Herpes Simplex Virus Type 1 and type 2 in Thuringia, Germany, 1999 to 2006. European Surveillance 2011;16:20005. DOI: https://doi.org/10.2807/ese.16.44.20005-en
Apurba SS, Sandhya BK, Senthamarai S, et al. Serological Evaluation of Herpes Simplex Virus Type- 1/ Type- 2 Infections in Pregnant Women with Bad Obstetric History in a Tertiary Care Hospital, Kanchipuram. International Journal of Advance Research 2013;1:123-8.
Sadiq MS, Fatima H, Jamil K, Patil C. Study of TORCH profile in patients with bad obstetric history. Biology and Medicine 2012;4:95-101.
Obeid OE. Prevalence of herpes simplex virus types 1 and 2 and associated sociodemographic variables in pregnant women attending king Fahd hospital of the university. J. Family Community Med 2007;14:3-7.
Rezaei-Chaparpordi S, Assmar M, Amirmozafari N, et al. Seroepidemiology of Herpes Simplex Virus Type 1 and 2 in Northern Iran. Iran. Journal of Public Health, 2012;41:75-9.
Sukik L, Alyafei M, Harfouche M, Abu-Raddad LJ. "Herpes simplex virus type 1 epidemiology in Latin America and the Caribbean: Systematic review and meta-analytics." PLoS ONE 2019;14:e0215487. DOI: https://doi.org/10.1371/journal.pone.0215487
Smith JS, Robinson NJ. Age-specific prevalence of infection with herpes simplex virus types 2 and 1: a global review. Journal of Infectious Disease 2002;186:S3–S28. DOI: https://doi.org/10.1086/343739
Malkin JE, Morand P, Malvy D, et al. Seroprevalence of HSV-1 and HSV-2 infection in the general French population. Sexual Transmitted Infections 2002;78:201–3. DOI: https://doi.org/10.1136/sti.78.3.201

How to Cite

Okonko, I. O., Benjamin, A. F., Cookey, T. I., Okonko, B. J., & Innocent-Adiele, H. (2023). Prevalence of Herpes Simplex Virus Type-2 IgG Antibody among pregnant women in Port-Harcourt, Nigeria. Microbiologia Medica, 38(1). https://doi.org/10.4081/mm.2023.10829
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