Morphological and ultrastructural changes induced by essential oil of Melaleuca alternifolia on drug-sensitive and drug-resistant strains of Candida albicans

M. Colone; N. Mastrangelo; F. Mondello; L. Toccacieli; L. Cerqua; A. Stringaro

doi:10.4081/microscopie.2011.4979

Authors

M. Colone Department of Technology and Health, Istituto Superiore di Sanità, Rome, Italy.
N. Mastrangelo Department of Technology and Health, Istituto Superiore di Sanità, Rome, Italy.
F. Mondello Department of Infectious, Parasitic and Immune-Mediated Diseases, Istituto Superiore di Sanità, Rome, Italy.
L. Toccacieli Department of Technology and Health, Istituto Superiore di Sanità, Rome, Italy.
L. Cerqua ASL AVEZ/SULM/AQ P.O. Tagliacozzo, L'Aquila, Italy.
A. Stringaro
annarita.stringaro@iss.it
Department of Technology and Health, Istituto Superiore di Sanità, Rome, Italy.

The essential oil of Melaleuca alternifolia (Tea Tree Oil: TTO) exhibits broad-spectrum antimicrobial activity. Here, we report the effects of TTO treatment against the yeast Candida albicans. Previous proliferation study showed that TTO was effective both on fluconazole-susceptible (3153) and on resistant isolate (AIDS68) strains of C. albicans. The cells of the two strains were treated with 1% TTO. The analysis was carried out by transmission and scanning electron microscopy to assess the changes induced by treatment both on the wall and the cell membrane of yeasts.

Colone, M., Mastrangelo, N., Mondello, F., Toccacieli, L., Cerqua, L., & Stringaro, A. (2011). Morphological and ultrastructural changes induced by essential oil of Melaleuca alternifolia on drug-sensitive and drug-resistant strains of Candida albicans. Microscopie, 16(2), 49–53. https://doi.org/10.4081/microscopie.2011.4979

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