https://doi.org/10.4081/jsas.2009.352

SELECTIVE INFLUENCES IN THE B-CELL RECEPTOR IMMUNOGLOBULIN HEAVY AND LIGHT CHAIN IN HAIRY CELL LEUKEMIA

Vol. 1 No. 1 (2009)
Submitted: 10 January 2012
Accepted: 10 January 2012
Published: 10 January 2012
Abstract Views: 744
PDF: 979
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Authors

F. Forconi
info@pagepress.org
Ematology Unit, Dept. of Clinical Medicine and Immunological Sciences, University of Siena, Italy.
T. Amato
Ematology Unit, Dept. of Clinical Medicine and Immunological Sciences, University of Siena, Italy.
E. Sozzi
Ematology Unit, Dept. of Clinical Medicine and Immunological Sciences, University of Siena, Italy.
E. Cencini
Ematology Unit, Dept. of Clinical Medicine and Immunological Sciences, University of Siena, Italy.
D. Raspadori
Ematology Unit, Dept. of Clinical Medicine and Immunological Sciences, University of Siena, Italy.
F. Lauria
Ematology Unit, Dept. of Clinical Medicine and Immunological Sciences, University of Siena, Italy.
Hairy cell leukemia (HCL) is a rare, chronic B-cell neoplasm characterized by leukemic hairy cells (HCs) present in blood, bone marrow, and splenic red pulp, with atrophy of white pulp. Lymph node involvement is infrequent. HCL is typically associated with markers of activation, that include expression of CD25, CD11c, FMC7, and CD103 at high intensity. A distinctive feature of HCL is expression of multiple surface immunoglobulin (sIg) isotypes, although its prevalence in HCL is not fully mapped.

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How to Cite

Forconi, F., Amato, T., Sozzi, E., Cencini, E., Raspadori, D., & Lauria, F. (2012). SELECTIVE INFLUENCES IN THE B-CELL RECEPTOR IMMUNOGLOBULIN HEAVY AND LIGHT CHAIN IN HAIRY CELL LEUKEMIA. Journal of the Siena Academy of Sciences, 1(1), 18–26. https://doi.org/10.4081/jsas.2009.352

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