https://doi.org/10.4081/jbr.2018.7202

The link between the genetic polymorphisms of the innate immune signaling molecular factors with periodontitis

Vol. 91 No. 1 (2018)
Submitted: November 21, 2017
Accepted: June 13, 2018
Published: June 29, 2018
Polymorphisms, microRNA, apolipoproteinE.
Abstract Views: 751
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Authors

Gurumoorthy Kaarthikeyan
drkarthik79@yahoo.co.in
Department of Periodontics, Saveetha Dental College, Saveetha University, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
Anandan Balakrishnan
Department of Genetics, AL Mudaliyar Post Graduate Institute of Basic Medical Sciences, Chennai, India.
Nadathur Doraisamy Jayakumar
Department of Periodontics, Saveetha Dental College, Saveetha University, Saveetha Institute of Medical and Technical Sciences, Chennai, India.
Periodontitis is a chronic inflammatory disease causing destruction of supporting tissues of teeth. Even though the gramnegative anaerobes are essential for the initiation of periodontal destruction, multiple risk factors are essential for the progression of the disease. The genetic risk factor plays a significant role in the etiopathogenesis of periodontal disease. The innate immune mechanism is the first line of defense in screening and combating the invading periodontal pathogens. The genetic polymorphisms in the 3’UTR region of the innate immune signaling molecular factors like toll-like receptors, nod-like receptors and the polymorphisms in the epigenetic regulators of these factors like microRNA146a, apolipoproteinE might play an important role in the etiopathogenesis of periodontal destruction.

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How to Cite

Kaarthikeyan, G., Balakrishnan, A., & Jayakumar, N. D. (2018). The link between the genetic polymorphisms of the innate immune signaling molecular factors with periodontitis. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 91(1). https://doi.org/10.4081/jbr.2018.7202

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