https://doi.org/10.4081/jbr.2011.4638

Protective effects of Resveratrol in an experimental model of abdominal aortic aneurysm induction

Vol. 84 No. 1 (2011)
Submitted: July 30, 2014
Accepted: July 30, 2014
Published: January 30, 2011
Andominal aortic aneurysm, Monocytes, MMPs, TNF-α
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Authors

D. Palmieri
danielapalmieri@yahoo.it
C. Barisione
C, Pane
G. Spinella
S. Garibaldi
G. Ghigliotti
C. Brunelli
E. Fulcheri
D. Palombo
Resveratrol (Rsv) is a natural antioxidant polyphenol with vasoprotective properties. We evaluated whether Rsv affects the inflammatory response in an experimental model of elastase-induced abdominal aortic aneurysm. Thirty male rats were subjected to aneurysm induction and treated or not with Rsv. Circulating levels of CD62L-monocyte subset, monocyte CD I 43 surface expression, MMP-9 plasma activity and TNFα serum levels were lower in Rsv-treated rats. In conclusion. Rsv acts as an anti-inflammatory compound and could be of great revelance to improve the immune response in AAA patients.

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How to Cite

Palmieri, D., Barisione, C., Pane, C., Spinella, G., Garibaldi, S., Ghigliotti, G., Brunelli, C., Fulcheri, E., & Palombo, D. (2011). Protective effects of Resveratrol in an experimental model of abdominal aortic aneurysm induction. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 84(1). https://doi.org/10.4081/jbr.2011.4638

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