https://doi.org/10.4081/jbr.2014.2135

K:D-Rib: cancer cell proliferation inibitor and DNAzyme folding promoter

Vol. 87 No. 1 (2014): Proceedings of the 85th SIBS Congress
Submitted: November 21, 2013
Accepted: November 21, 2013
Published: January 10, 2014
HTB-126 cell line, DNAzyme, cancer, K ion and D-ribose
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Authors

Luca Bruni
luca.bruni@nemo.unipr.it
Unit of Biophysics and Medical Physics, Department of Neuroscience, University of Parma, Italy.
Simonetta Croci
INBB National Institute of Biostructures and Biosystems, Rome, Italy.
We report the effects of K:D-Rib, a D-ribose and KHCO3 water solution on HTB-126 human cancer cell line proliferation and the preliminary ultraviolet-visible (UV-VIS) measures of DNAzyme as biosensor of extracellular K+ concentration. On the one hand, we demonstrate that the synergic action of KHCO3 and D-ribose from one side has a cytostatic effect on human breast cancer cell line increasing by 30% the doubling population time of treated cells with respect to the control; and on the other hand we demonstrate how it seems to permit the K+ uptake.

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Supporting Agencies

this investigation was supported by the Valsè Pantellini Foundation, Oviedo, Spain, and Fondazione Cariparma, Parma, Italy

How to Cite

Bruni, L., & Croci, S. (2014). K:D-Rib: cancer cell proliferation inibitor and DNAzyme folding promoter. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 87(1). https://doi.org/10.4081/jbr.2014.2135

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