https://doi.org/10.4081/jbr.2014.2128

Can a single low-intensity premature stimulus induce ventricular arrhythmias in the normal heart?

Vol. 87 No. 1 (2014): Proceedings of the 85th SIBS Congress
Submitted: November 21, 2013
Accepted: November 21, 2013
Published: January 10, 2014
premature stimulation, conduction block, reentry circuit, arrhythmia
Abstract Views: 1287
PDF: 776
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Authors

Stefano Rossi
Department of Biosciences, University of Parma, Italy.
Silvana Baruffi
Department of Biosciences, University of Parma, Italy.
Sergio Callegari
Department of Cardiology, Vaio Hospital, Fidenza, Italy.
Luca Carnevali
Department of Neurosciences, University of Parma, Italy.
Domenico Corradi
Department of Biomedical, Biotechnological and Translational Sciences, University of Parma, Italy.
Michele Miragoli
Centre of excellence for Toxicological Research, University of Parma, Italy.
Ezio Musso
Department of Biosciences, University of Parma, Italy.
Andrea Sgoifo
Department of Neurosciences, University of Parma, Italy.
Mimosa Trombini
Department of Biosciences, University of Parma, Italy.
Emilio Macchi
emilio.macchi@unipr.it
Centre of excellence for Toxicological Research, University of Parma, Italy.
Previously, we observed that a single low-intensity premature ventricular stimulation could occasionally induce spontaneous ectopic beats in normal rat hearts. Possible hypothesis for the arrhythmia is that a premature beat can encounter a zone of conduction block to initiate reentry. However, enhanced dispersion of repolarization, a necessary condition for initiation of reentry, is unlikely to be present in normal myocardium. Thus, the main objective of the present study was to perform detailed pace mapping measurements in normal ventricular myocardium with a view to identify pacing sites and critical coupling intervals which could induce spontaneous ectopic beats and to characterize the reentrant circuits.

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Supporting Agencies

authors received financial support from Fondazione CARIPARMA, Bilancio 2010

How to Cite

Rossi, S., Baruffi, S., Callegari, S., Carnevali, L., Corradi, D., Miragoli, M., Musso, E., Sgoifo, A., Trombini, M., & Macchi, E. (2014). Can a single low-intensity premature stimulus induce ventricular arrhythmias in the normal heart?. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 87(1). https://doi.org/10.4081/jbr.2014.2128

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