https://doi.org/10.4081/jbr.2025.13533
0
0
0
0
Smart Citations
0
0
0
0
Citing PublicationsSupportingMentioningContrasting
View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Unveiling the muco-microbiotic layer: a three-component framework for mucosal health and disease

Authors

Francesco Cappello
francesco.cappello@unipa.it
https://orcid.org/0000-0001-9288-1148
Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy.
Melania I. Gratie
Department of Biomedicine, Neuroscience and Advanced Diagnostics, University of Palermo, Palermo, Italy.

We wish to bring attention to the critical role of the muco-microbiotic layer, a dynamic and integrated system located at mucosal surfaces. This layer represents a cornerstone of host-microbe interactions, composed of three key components: the mucus, the microbiota, and extracellular nanovesicles (commonly referred to as exosomes).

Dimensions

Altmetric

PlumX Metrics

Plum Print visual indicator of research metrics
    No metrics available.
see details

Downloads

Citations

Crossref
0
Scopus
0
Google Scholar
Europe PMC
Fucarino A, Burgio S, Paladino L, et al. The Microbiota is not an organ: Introducing the muco-microbiotic layer as a novel morphofunctional structure. Anatomia 2022;1:186-203. DOI: https://doi.org/10.3390/anatomia1020019
Cappello F, Saguto D, Burgio S, et al. Does intestine morphology still have secrets to reveal? A proposal about the “ghost” layer of the bowel. Appl Biosci 2022;1:95-100. DOI: https://doi.org/10.3390/applbiosci1010006
Paladino L, Rappa F, Barone R, et al. NF-kB regulation and the chaperone system mediate restorative effects of the probiotic Lactobacillus fermentum LF31 in the small intestine and cerebellum of mice with ethanol-induced damage. Biology (Basel) 2023;12:1394. DOI: https://doi.org/10.3390/biology12111394
Cappello F, Rappa F, Canepa F, et al. Probiotics can cure oral aphthous-like ulcers in inflammatory bowel disease patients: A review of the literature and a working hypothesis. Int J Mol Sci 2019;20:5026. DOI: https://doi.org/10.3390/ijms20205026

How to Cite

Cappello, F., & Gratie, M. I. (2025). Unveiling the muco-microbiotic layer: a three-component framework for mucosal health and disease. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale. https://doi.org/10.4081/jbr.2025.13533
Copyright (c) 2025 the Author(s) Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.


Similar Articles

1 2 > >> 

You may also start an advanced similarity search for this article.