https://doi.org/10.4081/jbr.2024.12050
The role of selenium in autoimmune thyroiditis
Submitted: November 4, 2023
Accepted: February 18, 2024
Published: March 21, 2024
Accepted: February 18, 2024
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Selenium (Se) is an essential trace element of fundamental importance for human health. Se is incorporated into selenoproteins (SPs) which are endowed with pleiotropic effects including antioxidant and anti-inflammatory effects and active production of thyroid hormones. It has also been suggested that Se plays a crucial role in the pathogenesis of various human diseases. The therapeutic effects of supplementation with Se have already been described in various thyroid diseases. However, there are still conflicting results regarding the optimal dose of Se to administer and the duration of treatment, efficacy, and safety. The highly beneficial effects of supplementation with Se have been observed in subjects with thyroid disease in the hyperthyroid phase. In line with these observations, clinical studies have shown that in patients with Basedow's disease (BD) and autoimmune thyroiditis (AT), treatment with a combination of antithyroid drugs and Se restores the euthyroid state faster than administration of antithyroid drugs alone. However, the efficacy of this therapeutic approach remains to be better evaluated.
Benvenga S, Feldt-Rasmussen U, Bonofiglio D, Asamoah E. Nutraceutical supplements in the thyroid setting: health benefits beyond basic nutrition. Nutrients 2019;11:2214.
DOI: https://doi.org/10.3390/nu11092214
Duntas LH. The role of iodine and selenium in autoimmune thyroiditis. Horm Metab Res 2015;47:721-6.
DOI: https://doi.org/10.1055/s-0035-1559631
Weeks BS, Hanna MS, Cooperstein D. Dietary selenium and selenoprotein function. Med Sci Monit 2012;18:127-132.
DOI: https://doi.org/10.12659/MSM.883258
Vyacheslav M, Labunskyy, Dolph L et al. Selenoproteins: molecular pathways and physiological roles. Physiol Rev 2014;94:739-77.
DOI: https://doi.org/10.1152/physrev.00039.2013
Shimada BK, Alfulaij N, Lucia A. Seale LA. The impact of selenium deficiency on cardiovascular function. Int J Mol Sci 2021;22:10713.
DOI: https://doi.org/10.3390/ijms221910713
Moghadaszadeh B, Petit N, Jaillard C, et. al. Mutations in SEPN1 cause congenital muscular dystrophy with spinal rigidity and restrictive respiratory syndrome. Nature Genet 2001;29:17-8.
DOI: https://doi.org/10.1038/ng713
Cai X, Wang C, Yu W, et al. Selenium exposure and cancer risk: an updated meta-analysis and meta-regression. Sci Rep 2016;6:19213.
DOI: https://doi.org/10.1038/srep19213
Qazi IH, Angel C, Yang H, et al. Role of selenium and selenoproteins in male reproductive function: A review of past and present evidences. Antioxidants 2019;8:268.
DOI: https://doi.org/10.3390/antiox8080268
Hariharan S, Selvakumar Dharmaraj S. Selenium and selenoproteins: it’s role in regulation of inflammation. Inflammopharmacology 2020;28:667-95.
DOI: https://doi.org/10.1007/s10787-020-00690-x
Kohrle J. The deiodinase family: selenoenzymes regulating thyroid hormone availability and action. Cell Mol Life Sci 2000;57:1853-63.
DOI: https://doi.org/10.1007/PL00000667
Rayman MP. Selenium and human health. Lancet 2012;379:1256-68.
DOI: https://doi.org/10.1016/S0140-6736(11)61452-9
Beck MA, Levander OA, Handy J. Selenium deficiency and viral infection. J Nutr 2003;133:1463S-7S.
DOI: https://doi.org/10.1093/jn/133.5.1463S
Stone CA, Kawai K, Kupka R, Fawzi WW. Role of selenium in HIV infection. Nutr Rev 2010;68:671-81.
DOI: https://doi.org/10.1111/j.1753-4887.2010.00337.x
Steinbrenner H, Speckmann B, Sies H. Toward understanding success and failures in the use of selenium for cancer prevention. Antioxid Redox Signal 2013;10;181-91.
DOI: https://doi.org/10.1089/ars.2013.5246
Przybylik-Mazurek E, Zagrodzki P, Kuźniarz-Rymarz S, Hubalewska-Dydejczyk A. Thyroid disorders-assessments of trace elements, clinical, and laboratory parameters. Biol Trace Elem Res 2011;141:65-75.
DOI: https://doi.org/10.1007/s12011-010-8719-9
Schomburg L. Selenium, selenoproteins and the thyroid gland: interactions in health and disease. Nat Rev Endocrinol 2011;8:160-71.
DOI: https://doi.org/10.1038/nrendo.2011.174
Flohé L, Andreesen JR, Brigelius-Flohé R, et al. Selenium, the element of the moon, in life and earth. IUBMB Life 2000;49:411-20.
DOI: https://doi.org/10.1080/152165400410263
Bierl C, Voetsch B, Jin RC, et al. Determinants of human plasma glutathione peroxidase (GPx-3) expression. J Biol Chem 2004;279:26839-45.
DOI: https://doi.org/10.1074/jbc.M401907200
Schomburg L, Köhrle J. On the importance of selenium and iodine metabolism for thyroidhormone biosynthesis and human health. Mol Nutr Food Res 2008;52:1235-46.
DOI: https://doi.org/10.1002/mnfr.200700465
Tsuji PA, Santesmasses D, Lee BJ, et al. Historical roles of selenium and selenoproteins in health and development: The good, the bad and the ugly. Int J Mol Sci 2022;23:5.
DOI: https://doi.org/10.3390/ijms23010005
Kuklinsky B, Schweder R. Acute pancreatitis, a free radical disease; reducing lethality with the sodium selenite and other antioxidants. J Nutr Environ Med 1996;6:393-4.
Kato MA, Finley DJ, Lubitz CC, et al. Selenium decreases thyroid cancer cell growth by increasing expression of GADD153 and GADD34. Nutr Cancer 2010;62:66-73.
DOI: https://doi.org/10.1080/01635580903191569
Glattre E, Nygard JF, Aaseth J. Selenium and cancer prevention: observations and complexity. J Trace Elem Med Biol 2012;26:168-9.
DOI: https://doi.org/10.1016/j.jtemb.2012.04.021
Mittag J, Behrends T, Hoefig CS, et al. Thyroid hormones regulate selenoprotein expression and selenium status in mice. PLoS One 2010;5:e12931.
DOI: https://doi.org/10.1371/journal.pone.0012931
Gillespie EF, Smith TJ, Douglas RS. Thyroid eye disease: towards an evidence base for treatment in the 21st century. Curr Neurol Neurosci Rep 2012;12:318-24.
DOI: https://doi.org/10.1007/s11910-012-0256-9
Wolfram T, Weidenbach LM, Adolf J, et al. The trace element selenium is important for redox signaling in phorbol ester-differentiated THP-1 macrophages. Int J Mol Sci 2021;22:11060.
DOI: https://doi.org/10.3390/ijms222011060
Burk RF, Hill KE. Selenoprotein P-Expression, functions, and roles in mammals. Biochim Biophys Acta 2009;1790:1441-7.
DOI: https://doi.org/10.1016/j.bbagen.2009.03.026
Ohta Y, Suzuki KT. Methylation and demethylation of intermediates selenide and methylselenol in the metabolism of selenium. Toxicol Appl Pharmacol 2008;226:169-77.
DOI: https://doi.org/10.1016/j.taap.2007.09.011
Köhrle J, Brigelius-Flohé R, Böck A, et al. Selenium in biology: facts and medical perspectives. Biol Chem 2000; 381:849-64.
DOI: https://doi.org/10.1515/BC.2000.107
Duntas LH. Environmental factors and thyroid autoimmunity. Ann Endocrinol 2011;72:108-13.
DOI: https://doi.org/10.1016/j.ando.2011.03.019
Gärtner R, Gasnier BC, Dietrich JW, et al. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations. J Clin Endocrinol Metab 2002;87:1687-91.
DOI: https://doi.org/10.1210/jcem.87.4.8421
Taylor EW. Selenium and cellular immunity. Evidence that selenoproteins may be encoded in the +1 reading frame overlapping the human CD4, CD8, and HLA-DR genes. Biol Trace Elem Res 1995;49:85-95.
DOI: https://doi.org/10.1007/BF02788958
Cheng W, Fu YX, Porres JM, et al. Selenium-dependent cellular glutathione peroxidase protects mice against a pro-oxidant-induced oxidation of NADPH, NADH, lipids, and protein. FASEB J 1999;13:1467-75.
DOI: https://doi.org/10.1096/fasebj.13.11.1467
Hill KE, Burk RF. Selenoprotein P: recent studies in rats and in humans. Biomed Environ Sci 1997;10:198-208.
Gromer S, Eubel JK, Lee BL, Jacob J. Human selenoproteins at a glance. Cell Mol Life Sci 2005;62:2414-37.
DOI: https://doi.org/10.1007/s00018-005-5143-y
Roy G, Sarma BK, Phadnis PP, Mugesh G. Selenium-containing enzymes in mammals: Chemical perspectives. J Chem Sci 2005;117:287-303.
DOI: https://doi.org/10.1007/BF02708441
Sunde RA, Raines AM, Barnes KM, Everson JK. Selenium status highly-regulates selenoprotein mRNA levels for only a subset of the selenoproteins in the selenoproteome. Biosci Rep 2009;29:329-38.
DOI: https://doi.org/10.1042/BSR20080146
Brigelius-Flohé R, Kipp A. Glutathione peroxidases in different stages of carcinogenesis. Biochim Biophys Acta 2009;1790:1555-68.
DOI: https://doi.org/10.1016/j.bbagen.2009.03.006
Imai H, Nakagawa Y. Biological significance of phospholipid hydroperoxide glutathione peroxidase (PHGPx, GPx4) in mammalian cells. Free Radical Biol Med 2003;34:145-69.
DOI: https://doi.org/10.1016/S0891-5849(02)01197-8
Chabory E, Damon C, Lenoir A, et al. Mammalian glutathione peroxidases control acquisition and maintenance of spermatozoa integrity. J Anim Sci 2010;88:1321-31.
DOI: https://doi.org/10.2527/jas.2009-2583
Sun Q, Mehl S, Renko K, et al. Natural autoimmunity to Selenoprotein P impairs selenium transport in Hashimoto’s thyroiditis. Int J Mol Sci 2021;22:13088.
DOI: https://doi.org/10.3390/ijms222313088
Giammanco M, Di Liegro CM, Schiera G, Di Liegro I. Genomic and non-genomic mechanisms of action of thyroid hormones and their catabolite 3,5-diiodo-L-thyronine in mammals. Int J Mol Sci 2020;21:4140.
DOI: https://doi.org/10.3390/ijms21114140
Bianco AC, Reed Larsen P. Intracellular pathways of iodothyronine metabolism, in Wener and Ingbar’s The Thiroyd: a Fundamental and Clinical Text, 9th Ed., Braverman L.E., Utiger R.D. Eds, Lippincot Williams and Wilkins, Philadelphia, 2005, pp. 109.
Holmgren A, Lu J. Thioredoxin and thioredoxin reductase: Current research with special reference to human disease. Biochem Bioph Res Com 2010;396:120-4.
DOI: https://doi.org/10.1016/j.bbrc.2010.03.083
Moskovitz J, Bar-Noy S, Williams WM, et al. Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals, Proc Natl Acad Sci USA 2001;23:12920-5.
DOI: https://doi.org/10.1073/pnas.231472998
Mitsui A, Hamuro J, Nakamura H, et al. Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. Antioxid Redox Signal 2002;4:693-6.
DOI: https://doi.org/10.1089/15230860260220201
Lillig CH, Holmgren A. Thioredoxin and related molecules: from biology to health and disease. Antioxid Redox Signal 2007;9:25-47.
DOI: https://doi.org/10.1089/ars.2007.9.25
Mehdi Y, Hornick JL, Istasse L, Dufrasne I. Selenium in the environment, metabolism and involvement in body functions. Molecules 2013;18:3292-311.
DOI: https://doi.org/10.3390/molecules18033292
Das S, Bhansali A, Dutta P, et al. Persistence of goitre in the post-iodization phase: micronutrient deficiency or thyroid autoimmunity? Indian J Med Res 2011;133:103-9.
Aydin K, Kendirci M, Kurtoğlu S, et al. Iodine and selenium deficiency in school children in an endemic goitre area in Turkey. J Pediatr Endocrinol Metab 2002;15:1027-31.
DOI: https://doi.org/10.1515/JPEM.2002.15.7.1027
Xia Y, Hill KE, Byrne DW, et al. Effectiveness of selenium supplements in a low-selenium area of China. Am J Clin Nutr 1998;81:829-34.
DOI: https://doi.org/10.1093/ajcn/81.4.829
Hira CK, Partal K, Dhillon KS. Dietary selenium intake by men and women in high and low selenium areas of Punjab. Public Health Nutr 2004;7:39-43.
DOI: https://doi.org/10.1079/PHN2003513
Fairweather-Tait SJ, Bao Y, Broadley MR, et al. Selenium in human health and disease. Antioxid Redox Signal 2011;14:1337-83.
DOI: https://doi.org/10.1089/ars.2010.3275
Thavarajah D, Thavarajah P, Wejesuriya A, et al. The potential of lentil (Lens culinaris L.) as a whole food for increased selenium, iron, and zinc intake: preliminary results from a 3 year study. Euphytica 2011;180:123-8.
DOI: https://doi.org/10.1007/s10681-011-0365-6
Tan J, Zhu W, Wang W, et al. Selenium in soil and endemic diseases in China. Sci Total Environ 2002;284:227-35.
DOI: https://doi.org/10.1016/S0048-9697(01)00889-0
Navarro-Alarcon M, Cabrera-Vique C. Selenium in food and the human body: a review. Sci Total Environ 2008;400:115-41.
DOI: https://doi.org/10.1016/j.scitotenv.2008.06.024
Dumont E, Vanhaecke F, Cornelis R. Selenium speciation from food source to metabolites: a critical review. Anal Bioanal Chem 2006;385:1304-23.
DOI: https://doi.org/10.1007/s00216-006-0529-8
Rayman MP, Infante HG, Sargent M. Food-chain selenium and human health: spotlight on speciation. Br J Nutr 2008;100:238-53.
DOI: https://doi.org/10.1017/S0007114508922522
Zou C, Yin D, Wang R. Mercury and selenium bioaccumulation in wild commercial fish in the coastal East China Sea: Selenium benefits versus mercury risks. Mar Poll Bull 2022;180:113754.
DOI: https://doi.org/10.1016/j.marpolbul.2022.113754
Fairweather-Tait SJ, Collings R, Hurst R. Selenium bioavailability: current knowledge and future research requirements. Am J Clin Nutr 2010;91:1484-91S.
DOI: https://doi.org/10.3945/ajcn.2010.28674J
Gärtner R. Selenium and thyroid hormone axis in critical ill states(?): an overview of conflicting view points. J Trace Elem Med Biol 2009;23:71-4.
DOI: https://doi.org/10.1016/j.jtemb.2009.01.001
Tiran B, Tiran A, Rossipal E, Lorenz O. Simple decomposition procedure for determination of selenium in whole blood, serum and urine by hydridegeneration atomic absorption spectroscopy. J Trace Elem Electrolytes Health Dis 1993;7:211-6.
Patterson P, Levander OA. Naturally occurring selenium compounds in cancer chemoprevention trials: a workshop summary. Cancer Epidemiol Biomarkers Prev 1997; 6:63-9.
Thomson CD, Campbell JM, Miller J, Skeaff SA. Minimal impact of excess iodate intake on thyroid hormones and selenium status in older New Zealanders. Eur J Endocrinol 2011;165:745-52.
DOI: https://doi.org/10.1530/EJE-11-0575
Thomson CD, Campbell JM, Miller J, et al. Selenium and iodine supplementation: effect on thyroid function of older New Zealanders. Am J Clin Nutr 2009;90:1038-46.
DOI: https://doi.org/10.3945/ajcn.2009.28190
Combs GF, Midthune DN, Patterson KY, et al. Effects of selenomethionine supplementation on selenium status and thyroid hormone concentrations in healthy adults. Am J Clin Nutr 2009;89:1808-14.
DOI: https://doi.org/10.3945/ajcn.2008.27356
Rayman MP, Thompson AJ, Bekaert B, et al. Randomized controlled trial of the effect of selenium supplementation on thyroid function in the elderly in the United Kingdom. Am J Clin Nutr 2008;87:370-8.
DOI: https://doi.org/10.1093/ajcn/87.2.370
Duffield AJ, Thomson CD, Hill KE, Williams S. An estimation of selenium requirements for New Zealanders. Am J Clin Nutr 1999;70:896-903.
DOI: https://doi.org/10.1093/ajcn/70.5.896
Olivieri O, Girelli D, Azzini M, et al. Low selenium status in the elderly influences thyroid hormones. Clin Sci (Lond) 1995;89:637-42.
DOI: https://doi.org/10.1042/cs0890637
Nacamulli D, Mian C, Petricca D, et al. Influence of physiological dietary selenium supplementation on the natural course of autoimmune thyroiditis. Clin Endocrinol (Oxf) 2010;73:535-9.
DOI: https://doi.org/10.1111/j.1365-2265.2009.03758.x
Rasmussen LB, Schomburg L, Köhrle J, et al. Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency. Eur J Endocrinol 2011;164:585-90.
DOI: https://doi.org/10.1530/EJE-10-1026
Onal H, Keskindemirci G, Adal E, et al. Effects of selenium supplementation in the early stage of autoimmune thyroiditis in childhood: an open-label pilot study. J Pediatr Endocrinol Metab 2012;25:639-44.
DOI: https://doi.org/10.1515/jpem-2012-0078
Marcocci C, Altea MA, Leo M. Treatment options for Graves' orbitopathy. Expert Opin Pharmacother 2012;13:795-806.
DOI: https://doi.org/10.1517/14656566.2012.668529
Giammanco M, Giammanco MM. Selenium: A cure for autoimmune thyroiditis. Endoc Metab Immune Disord Drug Targets 2021;21:1377-8.
DOI: https://doi.org/10.2174/1871530320666201014150147
Winther KH, Wichman JEM, Bonnema SJ, Hegedüs L. Insufficient documentation for clinical efficacy of selenium supplementation in chronic autoimmune thyroiditis, based on a systematic review and meta-analysis. Endocrine 2017;55:376-85.
DOI: https://doi.org/10.1007/s12020-016-1098-z
Winther KH, Rayman MP, Bonnema SJ, Hegedüs L. Selenium in thyroid disorders - essential knowledge for clinicians. Nat Rev Endocrinol 2020;16:165-76.
DOI: https://doi.org/10.1038/s41574-019-0311-6
Li N, Gao Z, Luo D, et al. Selenium level in the environment and the population of Zhoukoudian area, Beijing, China. Sci Total Environ 2007;381:105-11.
DOI: https://doi.org/10.1016/j.scitotenv.2007.03.027
Chen JS. An original discovery: selenium deficiency and Keshan disease (an endemic heart disease) Asia Pac J Clin Nutr 2012;21:320-6.
Wu Q, Rayman MP, Lv H, et al. Low Population selenium status is associated with increased prevalence of thyroid disease. J Clin Endocrinol Metab 2015;100:4037-47.
DOI: https://doi.org/10.1210/jc.2015-2222
Winther KH, Bonnema SJ, Cold F, et al. Does selenium supplementation affect thyroid function? Results from a randomized, controlled, double-blinded trial in a Danish population. Eur J Endocrinol 2015;172:657-67.
DOI: https://doi.org/10.1530/EJE-15-0069
Schweizer U, Dehina N, Schomburg L. Disorders of selenium metabolism and selenoprotein function. Curr Opin Pediatr 2011;23:429-35.
DOI: https://doi.org/10.1097/MOP.0b013e32834877da
Schomburg L, Dumitrescu AM, Liao XH, et al. Selenium supplementation fails to correct the selenoprotein synthesis defect in subjects with SBP2 gene mutations. Thyroid 2009;19:277-81.
DOI: https://doi.org/10.1089/thy.2008.0397
Wu Q, Wang Y, Chen P, et al. Increased incidence of Hashimoto's thyroiditis in selenium deficiency: a prospective six-year cohort study. J Clin Endocr Metab 2022;107:e3603-11.
DOI: https://doi.org/10.1210/clinem/dgac410
Kazi TG, Kandhro GA, Sirajuddin, et al. Evaluation of iodine, iron, and selenium in biological samples of thyroidmother and their newly born babies. Early Hum Dev 2010;86:649-55.
DOI: https://doi.org/10.1016/j.earlhumdev.2010.07.010
Di Majo D, La Guardia M, Leto G, et al. Flavonols and flavan-3-ols as modulators of xanthine oxidase and manganese superoxide dismutase activity. Int J Food Sci Nutr 2014;65:886-92.
DOI: https://doi.org/10.3109/09637486.2014.931362
Köhrle J, Jakob F, Contempré B, Dumont JE. Selenium, the thyroid, and the endocrine system. Endocr Rev 2005;26:944-84.
DOI: https://doi.org/10.1210/er.2001-0034
Stazi AV, Trinti B. Selenium status and over-expression of interleukin-15 in celiac disease and autoimmune thyroid diseases. Ann Ist Super Sanità 2010;46:389-99.
Petricca D, Nacamulli D, Mian C, et al. Effects of selenium supplementation on the natural course of autoimmune thyroiditis: a short review. J Endocrinol Invest 2012;35:419-24.
Balázs C, Kaczur V. Effect of selenium on HLA-DR expression of thyrocytes. Autoimmune Dis 2012:374635.
DOI: https://doi.org/10.1155/2012/374635
Morshed SA, Latif R, Davies TF. Delineating the autoimmune mechanisms in Graves' disease. Immunol Res 2012;54:191-203.
DOI: https://doi.org/10.1007/s12026-012-8312-8
Pedersen IB, Knudsen N, Carlé A, et al. Serum selenium is low in newly diagnosed Graves' disease: a population-based study. Clin Endocrinol (Oxf) 2013;79:584-90.
DOI: https://doi.org/10.1111/cen.12185
Xu J, Liu XL, Yang XF, et al. Supplemental selenium alleviates the toxic effects of excessive iodine on thyroid. Biol Trace Elem Res 2011;141:110-18.
DOI: https://doi.org/10.1007/s12011-010-8728-8
Bhuyan AK, Sarma D, Saikia UK. Selenium and the thyroid: A close-knit connection. Indian J Endocrinol Metab 2012;16:S354-5.
DOI: https://doi.org/10.4103/2230-8210.104090
Contempre B, Le-Moine O, Dumont JE, et al. Selenium deficiency and thyroid fibrosis. A key role for macrophages and transforming growth factor β (TGF-β). Mol Cell Endocrinol 1996;124:7-15.
DOI: https://doi.org/10.1016/S0303-7207(96)03921-4
Doupis J, Stavrianos C, Saltiki K, et al. Thyroid volume, selenium levels and nutritional habits in a rural region in Albania. Hormones 2009;8:296-302.
DOI: https://doi.org/10.14310/horm.2002.1246
Orgiazzi J. Anti-TSH receptor antibodies in clinical practice. Endocrinol Metab Clin North Am 2000;29:339-355.
DOI: https://doi.org/10.1016/S0889-8529(05)70135-3
Kloprogge SJ, Frauman AG. Expression of TSH-R in normal human extraocular muscles. Br J Ophthalmol 2006;90:124-5.
DOI: https://doi.org/10.1136/bjo.2005.084863
Khalilzadeh O, Noshad S, Rashidi A, Amirzargar A. Graves' ophthalmopathy: a review of immunogenetics. Curr Genomics 2011;12:564-75.
DOI: https://doi.org/10.2174/138920211798120844
Saravanan P, Dayan CM. Thyroid autoantibodies. Endocrinol Metab Clin North Am 2001;30:315-37.
DOI: https://doi.org/10.1016/S0889-8529(05)70189-4
Chardès T, Chapal N, Bresson D, et al. The human anti-thyroid peroxidase autoantibody repertoire in Graves' and Hashimoto's autoimmune thyroid diseases. Immunogenetics 2002;54:141-57.
DOI: https://doi.org/10.1007/s00251-002-0453-9
Gärtner R, Duntas LH. Effects of selenium supplementation on TPOAb and cytokines in acute autoimmune thyroiditis. Thyroid 2008;18:669-70.
DOI: https://doi.org/10.1089/thy.2008.0001
Karanikas G, Schuetz M, Kontur S, et al. No immunological benefit of selenium in consecutive patients with autoimmune thyroiditis. Thyroid 2008;18:7-12.
DOI: https://doi.org/10.1089/thy.2007.0127
Toulis KA, Anastasilakis AD, Tzellos TG, et al. Selenium supplementation in the treatment of Hashimoto's thyroiditis: a systematic review and a meta-analysis. Thyroid 2010;20:1163-73.
DOI: https://doi.org/10.1089/thy.2009.0351
Balázs C, Fehér J. The effect of selenium therapy on autoimmune thyroiditis. Clin Experimenta Med J 2009;3:269-77.
DOI: https://doi.org/10.1556/CEMED.3.2009.28408
Zagrodzki P, Ratajczak R. Selenium supplementation in autoimmune thyroiditis female patient-effects on thyroid and ovarian functions (case study). Biol Trace Elem Res 2008;126:76-82.
DOI: https://doi.org/10.1007/s12011-008-8188-6
Anastasilakis AD, Toulis KA, Nisianakis P, et al. Selenomethionine treatment in patients with autoimmune thyroiditis: a prospective, quasi-randomised trial. Int J Clin Pract 2012;66:378-8.
DOI: https://doi.org/10.1111/j.1742-1241.2011.02879.x
Bonfig W, Gärtner R, Schmidt H. Selenium supplementation does not decrease thyroid peroxidase antibody concentration in children and adolescents with autoimmune thyroiditis. Sci World J 2010;10:990-6.
DOI: https://doi.org/10.1100/tsw.2010.91
Weetman AP. Graves' disease. New Engl J Med 2000;343:1236-48.
DOI: https://doi.org/10.1056/NEJM200010263431707
Wertenbruch T, Willenberg HS, Sagert C, et al. Serum selenium levels in patients with remission and relapse of Graves' disease. Med Chem 2007;3:281-84.
DOI: https://doi.org/10.2174/157340607780620662
Duntas LH. Selenium and the thyroid: a close-knit connection. J Clin Endocrinol Metab 2010;95:5180-8.
DOI: https://doi.org/10.1210/jc.2010-0191
Vrca VB, Skreb F, Cepelak I, Mayer L. Supplementation with antioxidants in the treatment of Graves' disease: the effect on the extracellular antioxidative parameters. Acta Pharm 2004;54:79-89.
Tolando R, Jovanovic A, Brigelius-Flohé R, et al. Reactive oxygen species and proinflammatory cytokine signaling in endothelial cells: effects of selenium supplementation. Free Radic Biol Med 2000;28:979-86.
DOI: https://doi.org/10.1016/S0891-5849(00)00183-0
Hardy G, Hardy I, Manzanares W. Selenium supplementation in the critically iII. Nutr Clin Pract 2012;27:21-33.
DOI: https://doi.org/10.1177/0884533611434116
Xue H, Wang W, Li Y, et al. Selenium upregulates CD4(+) CD25(+) regulatory T cells in iodine-induced autoimmune thyroiditis model of NOD.H-2(h4) mice. Endocr J 2010;57:595-601.
DOI: https://doi.org/10.1507/endocrj.K10E-063
Duntas LH. Environmental factors and autoimmune thyroiditis. Nat Clin Pract Endocrinol Metab 2008;4:454-60.
DOI: https://doi.org/10.1038/ncpendmet0896
Rayman MP. Multiple nutritional factors and thyroid disease, with particular reference to autoimmune thyroid disease. P Nutr Soc 2019;78:34-44.
DOI: https://doi.org/10.1017/S0029665118001192
Rua RM, Nogales F, Carreras O, Ojeda ML. Selenium, selenoproteins and cancer of the thyroid. J Trace Elements Med Biol 2023;76:127115.
DOI: https://doi.org/10.1016/j.jtemb.2022.127115
Giammanco M, Mazzola M, Giammanco MM, et al. Selenium and autoimmune thyroiditis. Euro Mediter Biomed J 2023;18:54-8.
Benvenga S, Marini HR, Micali A, et al. Protective effects of myo-inositol and selenium on cadmium-induced thyroid toxicity in mice. Nutrients 2020;12:1222.
DOI: https://doi.org/10.3390/nu12051222
Morabito R, Remigante A, Arcuri B. Effect of cadmium on anion exchange capability through Band 3 protein in human erythrocytes. J Biol Res 2018;91:7203.
DOI: https://doi.org/10.4081/jbr.2018.7203
How to Cite
Giammanco, M., Bonfiglio, V. M., Giammanco, M. M., & Carini, F. (2024). The role of selenium in autoimmune thyroiditis. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 97(1). https://doi.org/10.4081/jbr.2024.12050
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