https://doi.org/10.4081/jbr.2024.11678
Reduced levels of genomic damage in young martial artists
Submitted: August 27, 2023
Accepted: December 11, 2023
Published: March 7, 2024
Accepted: December 11, 2023
Abstract Views: 1222
PDF: 146
Supplementary Materials: 37
Supplementary Materials: 37
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The impact of physical activity on the levels of genomic damage is still poorly understood. In this work, we aimed to investigate the influence of a constant martial arts training on the levels of DNA damage. Moreover, we explored the possible association between genomic damage and single-gene polymorphisms on metabolic and DNA repair genes. To do this, we compared the frequency of micronuclei and other nuclear aberrations in the buccal mucosa cells of 35 healthy, young martial artists with 35 healthy, young sedentary controls. Additionally, we genotyped all participants for three metabolic and two DNA repair genes to evaluate the impact of the relative single-gene polymorphisms on DNA damage. Genomic damage was significantly lower in athletes than in sedentary controls, as evidenced by a decrease in both micronuclei and total aberrations. Instead, single-gene polymorphisms did not significantly alter the frequencies of aberrations. These findings suggest that training may have a protective effect against genomic damage, supporting the health benefits provided by physical activity. The influence of other factors should be considered, and further studies focusing on disciplines with different training regimes are necessary to evaluate thoroughly their influence on genomic damage.
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How to Cite
Nota, A., Lambertini, M., & Santovito, A. (2024). Reduced levels of genomic damage in young martial artists. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 97(1). https://doi.org/10.4081/jbr.2024.11678
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