https://doi.org/10.4081/jbr.2023.11352

Iron metabolism and peripheral eosinophil count do not correlate in the general population

Vol. 96 No. 2 (2023)
Submitted: April 3, 2023
Accepted: July 25, 2023
Published: August 10, 2023
Iron, red cells, hemoglobin, ferritin, transferrin, peripheral eosinophils, sex
Abstract Views: 1234
PDF: 293
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Authors

Mara De Amici
https://orcid.org/0000-0003-1055-8123
Immuno-Allergology Laboratory of Clinical Chemistry and Pediatric Clinic, Foundation IRCCS Policlinic San Matteo, Pavia, Italy.
Riccardo Albertini
https://orcid.org/0000-0003-0462-0867
Laboratory of Clinical Chemistry, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Fiorella Barocci
https://orcid.org/0000-0002-0002-7698
Formerly Medicine Unit Laboratory, ASST Rhodense, Garbagnate Milanese, Rho (MI), Italy.
Tiziana Bosoni
https://orcid.org/0000-0003-3427-7465
Laboratory of Clinical Chemistry, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Laura Maria Ciardelli
https://orcid.org/0000-0002-8504-9609
Laboratory of Clinical Chemistry, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Annalisa De Silvestri
https://orcid.org/0000-0003-3128-8441
Scientific Direction, Clinical Epidemiology and Biometric Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Gian Luigi Marseglia
Pediatric Clinic, Fondazione IRCCS Policlinico San Matteo, Pavia; Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Italy.
Giorgio Ciprandi
gio.cip@libero.it
https://orcid.org/0000-0001-7016-8421
Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.

Iron is a primary component of the human body and exerts many functions, mainly concerning red cells and the immune system. In addition, there is evidence that iron-deficiency anemia is associated with allergic diseases. Type 2 inflammation characterizes allergic diseases. Peripheral eosinophils are a reliable biomarker for type 2 inflammation. Therefore, the present study investigated the possible relationship between iron metabolism and peripheral eosinophils in a large population. Eosinophils also play important roles in immune and tissue homeostasis. A growing body of data suggests tissue eosinophils represent a plastic and heterogeneous population of functional sub-phenotypes, shaped by environmental (systemic and local) factors. The retrospective study included 2795 subjects who were afferent to the Clinical Chemistry Analysis Laboratory during the year 2022. Men had higher peripheral eosinophil count than women (p<0.001). Furthermore, stratifications for sex, eosinophil, and hemoglobin cut-offs showed that men had more eosinophil counts than women. However, there was no correlation between iron biomarkers and peripheral eosinophils. The present study did not demonstrate a clear relationship between iron deficiency and peripheral eosinophil count. Even if this large population may include allergic subjects and patients with different diseases, it seems that iron does not directly affect eosinophil count.

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How to Cite

De Amici, M., Albertini, R., Barocci, F., Bosoni, T., Ciardelli, L. M., De Silvestri, A., Marseglia, G. L., & Ciprandi, G. (2023). Iron metabolism and peripheral eosinophil count do not correlate in the general population. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 96(2). https://doi.org/10.4081/jbr.2023.11352
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