https://doi.org/10.4081/jbr.2023.11027

Immuno-oncological treatment of non-small-cell lung cancer in advanced stage with nivolumab

Vol. 96 No. 1 (2023)
Submitted: November 21, 2022
Accepted: January 18, 2023
Published: March 2, 2023
Cancer, lung, immuno-oncology, Nivolumab
Abstract Views: 705
PDF: 122
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Authors

Fabio Venturella
Biological, Chemical, and Pharmaceutical Science and Technologies Department, University of Palermo, Palermo, Italy.
Giulia Cancellieri
https://orcid.org/0000-0002-2437-0108
Biological, Chemical, and Pharmaceutical Science and Technologies Department, University of Palermo, Palermo, Italy.
Marco Giammanco
Surgical, Oncological and Stomatological Disciplines Department, University of Palermo, Palermo, Italy.
Anna Maria Almerico
Biological, Chemical, and Pharmaceutical Science and Technologies Department, University of Palermo, Palermo, Italy.
Igor Daniele Aleo
Indipendent Researcher, Palermo, Italy.
Anastasia Valentina Liga
Biological, Chemical, and Pharmaceutical Science and Technologies Department, University of Palermo, Palermo, Italy.
Francesca Mortillaro
https://orcid.org/0000-0002-0374-3964
Biological, Chemical, and Pharmaceutical Science and Technologies Department, University of Palermo, Palermo, Italy.
Irene Mistretta
iremistre@gmail.com
Biological, Chemical, and Pharmaceutical Science and Technologies Department, University of Palermo, Palermo, Italy.

The field of immuno-oncology has brought about a significant paradigm shift in the therapeutic approach to cancer. The implementation of a novel therapeutic approach that seeks to stimulate the immune system's response to malignant cells has resulted in a notable alteration in the clinical trajectory of advanced Non-Small Cell Lung Cancer (NSCLC) treatment. The objective of our study was to assess the therapeutic effectiveness of nivolumab as a standalone treatment for patients diagnosed with advanced stage IIIB/IV non-small cell lung cancer, namely those who had progressed beyond the second line of treatment. The findings demonstrated a progression-free survival duration of 7.35 months and a notable enhancement in patients' quality of life when compared to alternative therapeutic interventions. Furthermore, it was shown that patients who received Nivolumab did not experience any adverse reactions classified as type 3 or type 4. It is anticipated that the encouraging findings obtained thus far will contribute to a future enhancement in overall survival rates.

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How to Cite

Venturella , F., Cancellieri, G., Giammanco, M., Almerico, A. M., Aleo, I. D., Liga, A. V., Mortillaro, F., & Mistretta, I. (2023). Immuno-oncological treatment of non-small-cell lung cancer in advanced stage with nivolumab. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 96(1). https://doi.org/10.4081/jbr.2023.11027
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