https://doi.org/10.4081/jbr.2022.10820

pH evaluation of storage fluids and ancient DNA extraction from wet specimens in pathology museums

Vol. 95 No. 2 (2022)
Submitted: August 29, 2022
Accepted: September 20, 2022
Published: October 7, 2022
Pathology museums, paleopathology, wet specimens, storage fluids, ancient DNA
Abstract Views: 969
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Authors

Luisa Ferrari
Division of Pathology, Cardinal Massaja Hospital, Asti; Department of Oncology, Pathology Unit, University of Turin, Italy.
Jasna Metovic
Department of Oncology, Pathology Unit, University of Turin, Italy.
Daniela Pulcinelli
Regional Centre of Immunohematology and Tissue Typing, San Salvatore Hospital, L’Aquila, Italy.
Antonio Lombardi
Regional Centre of Immunohematology and Tissue Typing, San Salvatore Hospital, L’Aquila, Italy.
Daniela Rullo
Division of Pathology, San Salvatore Hospital, L’Aquila, Italy.
Franco Papola
Regional Centre of Immunohematology and Tissue Typing, San Salvatore Hospital, L’Aquila, Italy.
Luca Ventura
lventura@asl1abruzzo.it
Division of Pathology, San Salvatore Hospital, L’Aquila; Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, Italy.

Pathology museums host ancient samples obtained during autopsies and generally used for educational purposes in the past. Such collections consist of dry and wet specimens showing diseases that no longer exist or with their natural course unmodified by modern therapies.1,2 In wet specimens, the preservation of macroscopic features due to the storage fluid has a great historical and paleopathological interest. Unfortunately, both original fixatives and storage fluids strongly influence tissue antigens and nucleic acids preservation.3 [...]

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Citations

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How to Cite

Ferrari, L., Metovic, J., Pulcinelli, D., Lombardi, A., Rullo, D., Papola, F., & Ventura, L. (2022). pH evaluation of storage fluids and ancient DNA extraction from wet specimens in pathology museums. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 95(2). https://doi.org/10.4081/jbr.2022.10820
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