https://doi.org/10.4081/jbr.2022.10632

Investigation of the effect of N-acetylcysteine on aluminum phosphide toxicity in rats

Vol. 95 No. 2 (2022)
Submitted: May 21, 2022
Accepted: August 12, 2022
Published: October 11, 2022
Aluminum phosphide, phosphine gas, liver enzymes, N-acetylcysteine
Abstract Views: 815
PDF: 413
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Authors

Ramin Parvizrad
Department of Emergency Medicine, Arak University of Medical Sciences, Arak, Iran, Islamic Republic of.
Elahe Ghorbani Marghamlki
Infectious Diseases Research Center (IDRC), Arak University of medical sciences, Arak, Iran, Islamic Republic of.
Somayeh Nikfar
Department of Gynecology, Arak University of Medical Sciences, Arak, Iran, Islamic Republic of.
Sara Khalili Dermani
saralhalili89@yahoo.com
Infectious Diseases Research Center (IDRC), Arak University of medical sciences, Arak, Iran, Islamic Republic of.

Aluminum Phosphide (ALP) is one of the most dangerous pesticides. When it comes into contact with water, it emits Phosphine (PH3) gas, which causes poisoning and death in many people. The purpose of this study is to look into the role of Nacetylcysteine in the treatment of aluminum phosphide toxicity in rats. In this study, 30 male Wistar rats were fed with aluminum phosphide orally. After 15 minutes, N-acetylcysteine was administered intraperitoneally. The antioxidant enzymes glutathione STransferase (GST), Superoxide Dismutase (SOD), Catalase (CAT), glutathione (GSH), Aspartate Aminotransferase (AST), Alanine Transaminase (ALT), and Alkaline Phosphatase (ALK) were studied in blood plasma. CAT, GST, and GSH concentrations in plasma, liver, and kidneys of rats infected with aluminum phosphide decreased, while AST, ALT, and ALK concentrations increased. The levels of all enzymes studied approached normal after N-acetylcysteine administration, and the rats survived for up to 12-15 hours. According to the findings of this study, N-acetylcysteine at a dose of 10 mg/kg improves hepatic manifestations and prevents liver necrosis, so it can be considered a potential therapeutic agent in the treatment of this poisoning.

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Citations

Crossref
Scopus
Google Scholar
Europe PMC
Tawfik H. Recent advances in management of aluminium phosphide poisoning. QJM 2020;113:hcaa049.02.
Tahergorabi Z, Zardast M, Naghizadeh A, et al. Effect of Aluminium Phosphide (ALP) gas inhalation exposure on adipose tissue characteristics and histological toxicity in male rats. J Taibah Univ Sci 2020;14:1317-25.
Hallaj S, Mohammadi AB, Ghorbani A, et al. Successful management of an aluminum phosphide poisoned patient following ventricular tachycardia. Int J Med Toxicol Forensic Med 2020;10:30473.
Lahlou A, Sidayne M, Benlamkaddem S, et al. Survival after aluminum phosphide poisoning in pregnancy. Case Rep Emerg Med 2020;2020:2785425.
Bogale DE, Ejigu BD, Muche TA. Clinical profile and treatment outcome of aluminum phosphide poisoning in felege hiwot referral hospital, Northwest Ethiopia: A retrospective study. OAEM 2021;13:239-48.
Oghabian Z, Mehrpour O. Treatment of aluminium phosphide poisoning with a combination of intravenous glucagon, digoxin and antioxidant agents. Sultan Qaboos University Med J 2016;16:e352-5.
Bumbrah GS, Krishan K, Kanchan T, et al. Phosphide poisoning: a review of literature. Forensic Sci Int 2012;214:1-6.
Chaudhry D, Rai AS. N-acetyl cysteine in aluminum phosphide poisoning: Myth or hope. Indian J Critical Care Med 2014;18:646-7.
Harrison GJ, McDonald D. Nutritional considerations section II. Clinical Avian Med 2006;1:108-40.
Jerram A, Guy TV, Beutler L, et al. Effects of storage time and temperature on highly multiparametric flow analysis of peripheral blood samples; implications for clinical trial samples. Biosci Rep 2021;41:BSR20203827.
Shami PJ, Saavedra JE, Wang LY, et al. JS-K, a glutathione/glutathione S-transferase-activated nitric oxide donor of the diazeniumdiolate class with potent antineoplastic activity. Mol Cancer Ther 2003;2:409-17.
Azad A, Lall SB, Mittra S. Effect of N-acetylcysteine and L-NAME on aluminium phosphide induced cardiovascular toxicity in rats. Acta Pharmacologica Sinica 2001;22:298-304.
Murali R, Bhalla A, Singh D, Singh S. Acute pesticide poisoning: 15 years experience of a large North-West Indian hospital. Clinical Toxicol 2009;47:35-8.
Saleki S, Ardalan FA, Javidan-Nejad A. Liver histopathology of fatal phosphine poisoning. Forensic Sci Int 2007;166:190-3.
Chugh S, Kishore K, Prakash V. Multisystem organ failure in acute aluminium phosphide poisoning. J Assoc Physic India 1998;46:983.
Chugh SN. Aluminium phosphide poisoning: present status and management. J Assoc Physicians India 1992;40:401-5.
Rahbar Taramsari M, Badsar A, Shafaghi Aet al. Alteration in liver enzymes in aluminum phosphide poisoning, a retrospective study. IJT 2013;7:854-85.
Mathai A, Bhanu MS. Acute aluminium phosphide poisoning: Can we predict mortality? Indian J Anaesth 2010;54:302-7.
Soltaninejad K, Nelson LS, Khodakarim N, et al. Unusual complication of aluminum phosphide poisoning: Development of hemolysis and methemoglobinemia and its successful treatment. Indian J Critical Care Med 2011;15:117-9.
Tehrani H, Halvaie Z, Shadnia S, et al. Protective effects of N-acetylcysteine on aluminum phosphide-induced oxidative stress in acute human poisoning. Clinical Toxicol 2013;51:23-8.
Moghadam Nia AA, Firooz Jahi AR, Javadian Sh, Dibavand N. Aluminium phosphide poisoning in mice and the procedure for its managements. JBUMS 2000;2:25-33.
El-Ebiary A, Abuelfad A. N-acetylcysteine as an adjuvant in the treatment of acute aluminum phosphide poisoning: a randomized clinical trial. Ain Shams J Forensic Med Clin Toxicol 2017;28:38-46.
Elgazzar FM, Keshk W, Khalifa H. Early L-carnitine therapy in severe acute aluminum phosphide poisoning: a randomized controlled clinical trial. Egyptian J Forensic Sci Applied Toxicol 2019;19:147-64.

How to Cite

Parvizrad, R., Marghamlki, E. G. ., Nikfar, S., & Dermani, S. K. . (2022). Investigation of the effect of N-acetylcysteine on aluminum phosphide toxicity in rats. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 95(2). https://doi.org/10.4081/jbr.2022.10632
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