https://doi.org/10.4081/jbr.2022.10594
Microbiota, probiotics and common skin cancer: Association and therapeutic application
Submitted: May 3, 2022
Accepted: August 6, 2022
Published: August 11, 2022
Accepted: August 6, 2022
Abstract Views: 2082
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Numerous commensal microorganisms live on human skin and play an important role in human health. Any type of abnormality in the skin microbiome can result in skin damage and various diseases. Skin disorders such as atopic dermatitis and psoriasis are common skin complications caused by an imbalance of skin microorganisms. Probiotics are live microorganisms that, when consumed in sufficient quantities, can benefit human health. Using probiotics to treat various skin complications has gained popularity in recent years. Probiotics have proven to be a promising agent for improving skin health and condition, with the potential to reduce skin pathogens and boost skin immunity through antimicrobial agent production and nutrient competition. The rising incidence of skin cancer, particularly melanoma, over the last four decades emphasizes this point. The link between skin microbiota imbalance and skin cancer, particularly Non-Melanoma Skin Cancer (NMSC) and melanoma, is becoming clearer. As a result, based on the proven ability of probiotics to improve skin health, the use of microorganisms such as probiotics as a supplement in conjunction with immunotherapy has gained popularity. The purpose of this review is to discuss the relationship between microbiota imbalance and skin cancer, as well as the use of probiotics in cancer treatment.
Mackowiak PA. Recycling Metchnikoff: probiotics, the intestinal microbiome and the quest for long life. Frontiers in Public Health 2013;1:52.
Williams NT. Probiotics. Am J Health-System Pharm 2010;67:449-58.
Tripathi MK, Giri SK. Probiotic functional foods: Survival of probiotics during processing and storage. J Func Foods 2014;9:225-41.
Bizzini B, Pizzo G, Scapagnini G, et al. Probiotics and oral health. Curr Pharm Des 2012;18:5522-31.
Lee JH, Nam SH, Seo WT, et al. The production of surfactin during the fermentation of cheonggukjang by potential probiotic Bacillus subtilis CSY191 and the resultant growth suppression of MCF-7 human breast cancer cells. Food Chem 2012;131:1347-54.
Iordache F, Iordache C, Chifiriuc MC, et al. Antimicrobial and immunomodulatory activity of some probiotic fractions with potential clinical application. Arch Zootechn 2008;11:41-51.
Abbasi N, Khosravi A, Aidy A, Shafiei M. Biphasic response to luteolin in MG-63 osteoblast-like cells under high glucose-induced oxidative stress. Iranian J Med Sci 2016;41:118-25.
Azad M, Kalam A, Sarker M, et al. Immunomodulatory effects of probiotics on cytokine profiles. Biomed Res Int 2018;23:8063647.
Pessi T, Sütas Y, Hurme M, et al. Interleukin‐10 generation in atopic children following oral Lactobacillus rhamnosus GG. Clin Exp Aller 2000;30:1804-8.
Kaur K, Kozlowska AK, Topchyan P, et al. Probiotic-treated super-charged NK cells efficiently clear poorly differentiated pancreatic tumors in Hu-BLT mice. Cancers 2019;12:63.
Begum J, Buyamayum B, Lingaraju MC, et al. Probiotics: Role in immunomodulation and consequent effects: Probiotics and immunity. Nutrient 2021;1:01-6.
Eslami M, Yousefi B, Kokhaei P, et al. Importance of probiotics in the prevention and treatment of colorectal cancer. J Cell Physiol 2019;234:17127-43.
Woo YR, Cho SH, Lee JD, Kim HS. The human microbiota and skin cancer. Int J Mol Sci 2022;23:1813.
Madhusudhan N, Pausan MR, Halwachs B, et al. Molecular profiling of keratinocyte skin tumors links Staphylococcus aureus overabundance and increased human β-defensin-2 expression to growth promotion of squamous cell carcinoma. Cancers 2020;12:541.
Krueger A, Mohamed A, Kolka CM, et al. Skin cancer-associated S. aureus Strains can induce DNA damage in human keratinocytes by downregulating DNA repair and promoting oxidative stress. Cancers 2022;14:2143.
Kullander J, Forslund O, Dillner J. Staphylococcus aureus and squamous cell carcinoma of the skin. Cancer Epidemiol Biomarkers Prev 2009;18:472-8.
Wood DL, Lachner N, Tan JM, et al. A natural history of actinic keratosis and cutaneous squamous cell carcinoma microbiomes. mBIO 2018;9:e01432-18.
Li H, Goh BN, Teh WK, et al. Skin commensal Malassezia globosa secreted protease attenuates Staphylococcus aureus biofilm formation. J Invest Dermatol 2018;138:1137-45.
Laikova KV, Oberemok VV, Krasnodubets AM, et al. Advances in the understanding of skin cancer: ultraviolet radiation, mutations, and antisense oligonucleotides as anticancer drugs. Molecules 2019;24:1516.
Mizuhashi S, Kajihara I, Sawamura S, et al. Skin microbiome in acral melanoma: Corynebacterium is associated with advanced melanoma. J Dermatol 2021;48:15-6.
Nakatsuji T, Chen TH, Butcher AM, et al. A commensal strain of Staphylococcus epidermidis protects against skin neoplasia. Sci Adv 2018;4:eaao4502.
Wang Z, Choi JE, Wu CC, Di Nardo. Skin commensal bacteria Staphylococcus epidermidis promote survival of melanocytes bearing UVB‐induced DNA damage, while bacteria Propionibacterium acnes inhibit survival of melanocytes by increasing apoptosis. Photodermatol Photoimmunol Photomed 2018;34:405-14.
Bibbò S, Ianiro G, Giambò F, et al. Role of gut microbiome on immunotherapy efficacy in melanoma. Hum Vaccin Immunother 2022;18:1926759.
Mortier L, Marchetti P, Delaporte E, et al. Progression of actinic keratosis to squamous cell carcinoma of the skin correlates with deletion of the 9p21 region encoding the p16INK4a tumor suppressor. Cancer Lett 2002;176:205-14.
Nakagawa S, Matsumoto M, Katayama Y, et al. Staphylococcus aureus virulent PSMα peptides induce keratinocyte alarmin release to orchestrate IL-17-dependent skin inflammation. Cell Host Microb 2017;22:667-77. e5.
Gaitanis G, Velegraki A, Magiatis P, et al. Could Malassezia yeasts be implicated in skin carcinogenesis through the production of aryl-hydrocarbon receptor ligands? Med Hypoth 2011;77:47-51.
Salava A, Aho V, Pereira P, et al. Skin microbiome in melanomas and melanocytic nevi. Med Hypoth 2016;26:49-55.
Cogen AL, Yamasaki K, Sanchez KM, et al. Selective antimicrobial action is provided by phenol-soluble modulins derived from Staphylococcus epidermidis, a normal resident of the skin. J Invest Dermatol 2010;130:192-200.
Cogen AL, Yamasaki K, Muto J, et al. Staphylococcus epidermidis antimicrobial δ-toxin (phenol-soluble modulin-γ) cooperates with host antimicrobial peptides to kill group A Streptococcus. J Invest Dermatol 2010;5:e8557.
Rollison DE, Viarisio D, Amorrortu RP, et al. An emerging issue in oncogenic virology: the role of beta human papillomavirus types in the development of cutaneous squamous cell carcinoma. J Invest Dermatol 2019;93:e01003-18.
Wang J, Aldabagh B, Yu J, Arron ST. Role of human papillomavirus in cutaneous squamous cell carcinoma: a meta-analysis. J Am Acad Dermatol 2014;70:621-9.
Wang L, Yi T, Kortylewski M, et al. IL-17 can promote tumor growth through an IL-6–Stat3 signaling pathway. J Exp Med 2009;206:1457-64.
Thatcher N, Wagstaff J, Mene A, et al. Corynebacterium parvum followed by chemotherapy (actinomycin D and DTIC) compared with chemotherapy alone for metastatic malignant melanoma. Eur J Cancer Clin Oncol 1986;22:1009-14.
Mekadim C, Skalnikova HK, Cizkova J, et al. Dysbiosis of skin microbiome and gut microbiome in melanoma progression. J Cancer Clin Oncol 2022;22:1-19.
Gur C, Ibrahim Y, Isaacson B, et al. Binding of the Fap2 protein of Fusobacterium nucleatumto human inhibitory receptor TIGIT protects tumors from immune cell attack. Immunity 2015;42:344-55.
Valdez J, Peral M, Rachid M, et al. Perdigon GJCm, infection. Interference of Lactobacillus plantarum with Pseudomonas aeruginosa in vitro and in infected burns: the potential use of probiotics in wound treatment. Clin Microbiol Infect 2005;11:472-9.
Nwanodi O. Skin protective nutraceuticals: the current evidence in brief. Healthcare 2018:6:40.
Prince T, McBain AJ, O’Neill CA. Lactobacillus reuteri protects epidermal keratinocytes from Staphylococcus aureus-induced cell death by competitive exclusion. Appl Environ Microbiol 2012;78:5119-26.
Mohammedsaeed W. Characterisation of the potential of probiotics or their extracts as therapy for skin: The University of Manchester, UK; 2015.
Lee J-A, Ko J-H, Jung B-G, et al. Fermented Prunus mume with probiotics inhibits 7, 12-dimethylbenz [a] anthracene and 12-o-tetradecanoyl phorbol-13-acetate induced skin carcinogenesis through alleviation of oxidative stress. Clin Microbiol Infect 2013;14:2973-8.
Kamaluddin WN, Rismayuddin NAR, Ismail AF, et al. Probiotic inhibits oral carcinogenesis: A systematic review and meta-analysis. Arch Oral Biol 2020;118:104855.
Aghazadeh Z, Pouralibaba F, Khosroushahi AY. The prophylactic effect of Acetobacter syzygii probiotic species against squamous cell carcinoma. J Dent Res Dent Clin Dent Prospects 2017;11:208-14.
Friedrich AD, Campo VE, Cela EM, et al. Oral administration of lipoteichoic acid from Lactobacillus rhamnosus GG overcomes UVB‐induced immunosuppression and impairs skin tumor growth in mice. Eur J Immunol 2019;49:2095-102.
Weill FS, Cela EM, Paz ML, et al. Lipoteichoic acid from Lactobacillus rhamnosus GG as an oral photoprotective agent against UV-induced carcinogenesis. Probiotics 2013;109:457-66.
Krueger A, Zaugg J, Lachner N, et al. Changes in the skin microbiome associated with squamous cell carcinoma in transplant recipients. ISME Communications 2022;2:1-10.
Sivan A, Corrales L, Hubert N, et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti–PD-L1 efficacy. Science 2015;350:1084-9.
Dey N, Ciorba MA. Probiotic gut bacteria enhance cancer immunotherapy in a mouse model of melanoma. Gastroenterology 2016;151:206-7.
Luo M, Hu M, Feng X, et al. Preventive effect of Lactobacillus reuteri on melanoma. Biomed Pharmacother 2020;126:109929.
Quezada SA, Peggs KS, Curran MA, et al. CTLA4 blockade and GM-CSF combination immunotherapy alters the intratumor balance of effector and regulatory T cells. J Clin Invest 2006;116:1935-45.
Chen L, Zhou X, Wang Y, et al. Propionate and butyrate produced by gut microbiota after probiotic supplementation attenuate lung metastasis of melanoma cells in mice. Mol Nutr Food Res 2021;65:e2100096.
Mager LF, Burkhard R, Pett N, et al. Microbiome-derived inosine modulates response to checkpoint inhibitor immunotherapy. Science 2020;369:1481-9.
Meng Z, Oh S. Antioxidant and Antimelanogenic activities of kimchi-derived Limosilactobacillus fermentum JNU532 in B16F10 melanoma cells. J Microbiol Biotechnol 2021; 31: 990-998.
Iqbal A, Irshad S, Saeed S, Tareen A. Probiotic potential of encapsulated Lactobacillus species in yogurt formation indigenously isolated from dairy source. Adv Life Sci 2021;8:267-274.
Farhad N, Shahsavari S. Probiotics and their effects in reduction hyperlipidemia. Plant Biotechnol Persa 2020;2:21-23
Rubbani U, Iqbal A. Evaluation of isolated Lactobacillus strains as Probiotics in yogurt preparation. Adv Life Sci 2020;7:79-85.
Rezaei M, Sanagoo A, Jouybari L, et al. The effect of probiotic yogurt on blood glucose and cardiovascular biomarkers in patients with type II diabetes: a randomized controlled trial. Evidence Based Care 2017;6:26-35.
Faghihi Shahrestani F, Tajabadi Ebrahimi M, Bayat M, et al. Identification of dairy fungal contamination and reduction of aflatoxin M1 amount by three acid and bile resistant probiotic bacteria. Arch Razi Inst 2021;76:119-126.
Kumar V, Bhatia M, Kumar A. Microbes from mouth to gut impacting probiotics to antibiotics. J Nat Sci Biol Med 2020;11:83-83.
How to Cite
Javaherian, M., Bakhtiari , R. ., Ajoudanifar, H., Shokri, S., & Mirzaie, A. (2022). Microbiota, probiotics and common skin cancer: Association and therapeutic application. Journal of Biological Research - Bollettino Della Società Italiana Di Biologia Sperimentale, 95(2). https://doi.org/10.4081/jbr.2022.10594
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